New Perspectives on Immunity to Infection
A. Sher, J.-L.Casanova, K. Fitzgerald, J. C. Howard,
EMBL Heidelberg, Germany
Saturday 19 May - Tuesday 22 May 2012
Programme
| 12:30 - 14:30 | Registration & Lunch |
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14:30 - 19:30 |
Session 1: Novel approaches for understanding the pathogenesis of infectious disease Session Chair Alan Sher - NIH, USA |
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14:30 - 14:45 |
Welcome & Symposium Overview Alan Sher - NIH, USA |
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14:45 - 15:15 |
Dissecting the human T and B cell response to pathogens Antonio Lanzavechia - IRB, Switzerland |
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15:15 - 15:45 |
Regulation of the immune response in tuberculosis: lessons learned from mouse models and human disease Anne O’Garra - National Institute for Medical Research, UK |
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15:45 - 16:00 |
Multifunctional monocyte and dendritic cell subsets co-express IL-1alpha and beta in the lungs of Mycobacterium tuberculosis infected mice and are subject to IFN regulation Katrin Mayer-Barber - NIAID, NIH, USA |
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16:00 - 16:30 |
Coffee Break |
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16:30 - 17:00 |
"to be announced" Robert Coffmann - Dynavax Technologies, USA |
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17:00 - 17:15 |
Unique role of IRF-5 in B cell IgG2a response Paula Pitha Rowe - Johns Hopkins University, USA |
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17:15 - 17:30 |
Innate Response Activator B Cells Protect Against Microbial Sepsis Philipp Rauch - MGH/Harvard Medical School and Heidelberg University |
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17:30 - 17:45 |
Roles for Treg cells in shaping the memory response to RSV infection "adaptive immunity? Lydia Durant - Imperial College London, UK |
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17:45 - 18:00 |
Highly dynamic exon shuffling in candidate pathogen receptors... What if brown algae were capable of of adaptive immunity? Claire Gachon - Scottish Association for Marine Science, UK |
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18:00 - 18:30 |
Coffee Break |
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18:30 - 19:30 |
Keynote Session Evolution of Adaptive Immunity Max Cooper - Emory University, USA |
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19:30 - 21:30 |
Dinner |
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20:00 - 23:00 |
Drinks in the Roof Top Lounge |
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09:00 - 12:30 |
Session 2 : Influence of the microbiome and nutrition on host defense Session Chair Eric Pamer - Memorial Sloan-Kettering Cancer Center, USA |
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09:00 - 09:30 |
Immunoregulation by helminth parasites Rick Maizels - University of Edinburgh, UK |
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09:30 - 09:45 |
Lipocalin 2 in protection of mucosal surfaces and shaping of intestinal microflora Trude Flo - NTNU, Norway |
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09:45 - 10:00 |
Pro-inflammatory and regulatory properties of caspase-1 are differentially mediated by its substrates IL-1beta and IL-18 in Helicobacter infection Ayca Sayi Yazgan - Istanbul Technical University, Turkey |
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10:00 - 10:30 |
Transcriptional regulation and role of the commensal microbiota in Th17 cell differentiation Dan Littman - New York University, USA |
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10:30 - 11:00 |
Coffee Break |
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11:00 - 11:30 |
IgA : a useful form of dementia? Andrew Macpherson - University of Bern, Switzerland |
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11:30 - 11:45 |
Bacillus subtilis diet increases Caenorhabditis elegans pathogen resistance by activating genes that regulate innate immunity Igor Iatsenko - Max Planck Institute for Developmental Biology, Germany |
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11:45 - 12:00 |
Endurance /tolerance: maintenance of Drosophila intestinal homeostasis upon oral infection with Serratia marcescens, which secretes a pore-forming toxin Kwang-Zin Lee - IBMC Strasbourg, France |
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12:00 - 12:30 |
Microbiota and innate immune defense against intestinal infection Eric Pamer - Memorial Sloan-Kettering Cancer Center, USA |
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12:30 - 14:30 |
Poster Session and Lunch |
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14:30 - 18:15 |
Session 3 :Genetic Determinants of host resistance Session Chair Jean-Laurent Casanova - Rockefeller Institute, USA |
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14:30 - 15:00 |
The evolutionary genetics approach in human immunity to infection Lluis Quintana-Murci - Pasteur Institute, France |
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15:00 - 15:30 |
Toward a genetic theory of infectious diseases Jean-Laurent Casanova - Rockefeller Institute, USA |
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15:30 - 16:00 |
Exome sequencing and forward genetic analysis of adaptive immunity Chris Goodnow - The Australian National University, Australia |
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16:00 - 16:30 |
Coffee Break |
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16:30- 17:00 |
Role of IRF transcriptional regulators in response to infection and in acute inflammation Phillipe Gros - McGill University, Canada |
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17:00 - 17:15 |
GILZ as a new protective gene against endotoxemia Claude Libert - VIB, Belgium |
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17:15 - 17:30 |
MicroRNA editing facilitates immune elimination of HCMV infected cells Daphna Nachmani - Hebrew University, Israel |
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17:30 - 17:45 |
IL-12Rb2 Is Essential for the Development of Experimental Cerebral Malaria Jennifer Palomo - CNRS, France |
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17:45 - 18:00 |
The Char10 locus modifies the malaria-protective effect of pyruvate kinase deficiency Aurelie Laroque - McGill University, Canada |
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18:00 - 18:15 |
Nlrp3 inflammasome-driven IL-1ß production is important for nitric oxide mediated resistance to Leishmania infection Djalma Lima-Junior - School of Medicine of Ribeirão Preto, University of São Paulo, Brazil |
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18:15 - 20:30 |
Dinner |
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19:30 - 23:00 |
Drinks in the Roof Top Lounge |
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09:00 - 12:30 |
Session 4: Molecular determinants of pathogen virulence Session Chair Dominique Soldati-Favre - University of Geneva, Switzerland |
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09:00 - 09:30 |
Molecular events governing the lytic cycle in Apicomplexa Dominique Soldati-Favre - University of Geneva, Switzerland |
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09:30 - 10:00 |
How is Plasmodium firstly recognized and controlled by the host? - a still fundamental but unanswered question Maria Mota - Instituto de Medicina Molecular, Portugal |
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10:00 - 10:15 |
Leishmania-infected mature dendritic cells polarize CD4+ T cells towards a non-protective T-bet+ INF-gamma+ IL10+ phenotype Mariana Resende - Institute for Molecular and Cell Biology, Porto, Portugal |
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10:15 - 10:30 |
IL-27Ra signaling: key regulator of immunopathology in influenza infection Francesca Diane Liu - German Institute for Rheumatology research, Germany |
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10:30 - 11:00 |
Coffee Break |
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11:00 - 11:30 |
TRIM5 is an innate immune sensor for the capsid lattice of HIV-1 and other retroviruses Jeremy Luban - University of Geneva, Switzerland |
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11:30 - 11:45 |
Adaptive signatures in primate APOBEC3G reveal ancient, pathogenic forms of Simian Immunodeficiency Virus Alex Compton - Fred Hutchinson Cancer Research Center, USA |
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11:45 - 12:15 |
Balancing the Signaling Pathways Involved in the Interaction of Mycobacterium tuberculosis with the Host Jean Pieters - University of Basel, Switzerland |
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12:15 - 12:30 |
A ricin-like lectin from Mycobacterium tuberculosis regulates immune responses Andre Bafica - Federal University of Santa Catarina, Brazil |
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12:30 - 14:30 |
Poster Session and Lunch |
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14:30 - 18:45 |
Session 5: Cell Biology of the host- pathogen interaction Session Chair Jonathan Howard - Cologne University, Germany |
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14:30-15:00 |
Location, Location, Location: Compartmentalized Translation As a Source of MHC Class I Peptide Ligands Jonathan Yewdell - NIAID NIH, USA |
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15:00 - 15:15 |
Shigella targets the adaptive immune response by inducing cell death in B lymphocytes Katharina Nothelfer - Institut Pasteur, INSERM U786, France |
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15:15 - 15:30 |
A DC receptor for damaged cells mediates cross-priming of CTL during vaccinia virus infection in mice Salvador Iborra - CNIC, Spain |
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15:30 - 16:00 |
Chromatin remodeling and a type III interferon response upon Listeria infection Pascale Cossart - Pasteur Institute, France |
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16:00 - 16:30 |
Coffee Break |
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16:30 - 17:00 |
NETs - from infection to autoimmunity Arturo Zychlinsky - Max Planck Institute Berlin, Germany |
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17:00 - 17:15 |
Viral ligands reposition activating and inhibitory receptors at the T-cell immune synapse to enhance inhibitory signalling: a novel mechanism for immune escape Marco Purbhoo - Imperial College London, UK |
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17:15 - 17:45 |
Toxoplasma and the mouse: a tale of the unexpected Jonathan Howard - Cologne University, Germany |
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17:45 - 18:45 |
Keynote Session Acute HIV-1 infection and the vaccine problem Andrew McMichael - Weatherall Institute of Molecular Medicine, UK |
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18:45 - 23:00 |
CONFERENCE DINNER AND PARTY |
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09:00 - 13:15 |
Session 6: Molecular mechanisms of innate recognition Session Chair Kate Fitzgerald - University of Massachusetts, USA |
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09:00 - 09:30 |
RNA silencing in defense, counter-defense and counter-counter-defense David Baulcombe - University of Cambridge, UK |
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09:30 - 10:00 |
The Drosophila gut: a new paradigm for innate immunity? Bruno Lemaitre - Polytechnical School of Lausanne, Switzerland |
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10:00 - 10:30 |
Caspase-11-dependent inflammasome activation by Gram-negative bacteria Kate Fitzgerald - University of Massachusetts, USA |
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10:30 - 11:00 |
Coffee Break |
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11:00 - 11:30 |
HMGB1 immunogenicity requires Nlrp3 inflammasome activation and processing by caspase-1 Maya Saleh - McGill University, Canada |
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11:30 - 12:00 |
A new role for the inflammasome in cellular defense Lynda Stuart - Massachusetts General Hospital / Harvard Medical School, USA |
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12:00 - 12:15 |
GADD34 is necessary for type-I interferon production in response to dsRNA and Chikungunya virus infection Philippe Pierre - CNRS, France |
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12:15 - 12:30 |
DNA-PK is a viral DNA sensor Brian Ferguson - University of Cambridge, UK |
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12:30 - 12:45 |
Anthrax lethal toxin cleavage of Nlrp1 is required for activation of the inflammasome Mahtab Moayeri - NIH/NIAID, USA |
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12:45 - 13:00 |
Dual Engagement of NLRP3 and AIM2 inflammasomes by hemozoin-complexed DNA during malaria infection Parisa Kalantari - University of Massachusetts Medical School, USA |
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13:00 - 13:15 |
Closing remarks - Conference Ends |