New Perspectives on Immunity to Infection

A. Sher, J.-L.Casanova, K. Fitzgerald, J. C. Howard,

EMBL Heidelberg, Germany

Saturday 19 May - Tuesday 22 May 2012

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Programme

 

Day 1 - Saturday, 19 May 2012
12:30 - 14:30 Registration & Lunch

14:30 - 19:30

Session 1: Novel approaches for understanding the pathogenesis of infectious disease

Session Chair Alan Sher - NIH, USA

14:30 - 14:45

Welcome & Symposium Overview

Alan Sher - NIH, USA

14:45 - 15:15

Dissecting the human T and B cell response to pathogens

Antonio Lanzavechia - IRB, Switzerland

15:15 - 15:45

Regulation of the immune response in tuberculosis: lessons learned from mouse models and human disease

Anne O’Garra - National Institute for Medical Research, UK

15:45 - 16:00

Multifunctional monocyte and dendritic cell subsets co-express IL-1alpha and beta in the lungs of Mycobacterium tuberculosis infected mice and are subject to IFN regulation

Katrin Mayer-Barber - NIAID, NIH, USA

16:00 - 16:30

Coffee Break

16:30 - 17:00

 "to be announced"

Robert Coffmann - Dynavax Technologies, USA

17:00 - 17:15

Unique role  of IRF-5 in B cell IgG2a response

Paula Pitha Rowe - Johns Hopkins University, USA

17:15 - 17:30

Innate Response Activator B Cells Protect Against Microbial Sepsis

Philipp Rauch - MGH/Harvard Medical School and Heidelberg University

17:30 - 17:45

Roles for Treg cells in shaping the memory response to RSV infection "adaptive immunity?

Lydia Durant - Imperial College London, UK

17:45 - 18:00

Highly dynamic exon shuffling in candidate pathogen receptors... What if brown algae were capable of of adaptive immunity?

Claire Gachon - Scottish Association for Marine Science, UK

18:00 - 18:30

Coffee Break

18:30 - 19:30

Keynote Session

Evolution of Adaptive Immunity

Max Cooper - Emory University, USA

19:30 - 21:30

Dinner

20:00 - 23:00

Drinks in the Roof Top Lounge

 

 

Day 2 - Sunday, 20 May 2012

09:00 - 12:30

Session 2 : Influence of the microbiome and nutrition on host defense

Session Chair Eric Pamer - Memorial Sloan-Kettering Cancer Center, USA

09:00 - 09:30

Immunoregulation by helminth parasites

Rick Maizels - University of Edinburgh, UK

09:30 - 09:45

Lipocalin 2 in protection of mucosal surfaces and shaping of intestinal microflora

Trude Flo - NTNU, Norway

09:45 - 10:00

Pro-inflammatory and regulatory properties of caspase-1 are differentially mediated by its substrates IL-1beta and IL-18 in Helicobacter infection

Ayca Sayi Yazgan - Istanbul Technical University, Turkey

10:00 - 10:30

Transcriptional regulation and role of the commensal microbiota in Th17 cell differentiation

Dan Littman - New York University, USA

10:30 - 11:00

Coffee Break

11:00 - 11:30

IgA : a useful form of dementia?

Andrew Macpherson - University of Bern, Switzerland

11:30 - 11:45

Bacillus subtilis diet increases Caenorhabditis elegans pathogen resistance by activating genes that regulate innate immunity

Igor Iatsenko - Max Planck Institute for Developmental Biology, Germany

11:45 - 12:00

Endurance /tolerance: maintenance of Drosophila intestinal homeostasis upon oral infection with Serratia marcescens, which secretes a pore-forming toxin

Kwang-Zin Lee - IBMC Strasbourg, France

12:00 - 12:30

Microbiota and innate immune defense against intestinal infection

Eric Pamer - Memorial Sloan-Kettering Cancer Center, USA

12:30 - 14:30

Poster Session and Lunch

14:30 - 18:15

Session 3 :Genetic Determinants of host resistance

Session Chair Jean-Laurent Casanova  - Rockefeller Institute, USA

14:30 - 15:00

The evolutionary genetics approach in human immunity to infection

Lluis Quintana-Murci - Pasteur Institute, France

15:00 - 15:30

Toward a genetic theory of infectious diseases

 Jean-Laurent Casanova - Rockefeller Institute, USA

15:30 - 16:00

Exome sequencing and forward genetic analysis of adaptive immunity

Chris Goodnow - The Australian National University, Australia

16:00 - 16:30

Coffee Break

16:30- 17:00

Role of IRF transcriptional regulators in response to infection and in acute inflammation

Phillipe Gros - McGill University, Canada

17:00 - 17:15

GILZ as a new protective gene against endotoxemia

Claude Libert - VIB, Belgium

17:15 - 17:30

MicroRNA editing facilitates immune elimination of HCMV infected cells

Daphna Nachmani - Hebrew University, Israel

17:30 - 17:45

IL-12Rb2 Is Essential for the Development of Experimental Cerebral Malaria

Jennifer Palomo - CNRS, France

17:45 - 18:00

The Char10 locus modifies the malaria-protective effect of pyruvate kinase deficiency

Aurelie Laroque - McGill University, Canada

18:00 - 18:15

Nlrp3 inflammasome-driven IL-1ß production is important for nitric oxide mediated resistance to Leishmania infection

Djalma Lima-Junior - School of Medicine of Ribeirão Preto, University of São Paulo, Brazil

18:15 - 20:30

Dinner

19:30 - 23:00

Drinks in the Roof Top Lounge

 

 

Day 3 - Monday, 21 May 2012

09:00 - 12:30

Session 4: Molecular determinants of pathogen virulence

Session Chair Dominique Soldati-Favre  - University of Geneva, Switzerland

09:00 - 09:30

Molecular events governing the lytic cycle in Apicomplexa

Dominique Soldati-Favre  - University of Geneva, Switzerland

09:30 - 10:00

How is Plasmodium firstly recognized and controlled by the host? - a still fundamental but unanswered question

Maria Mota - Instituto de Medicina Molecular, Portugal

10:00 - 10:15

Leishmania-infected mature dendritic cells polarize CD4+ T cells towards a non-protective T-bet+ INF-gamma+ IL10+ phenotype

Mariana Resende - Institute for Molecular and Cell Biology, Porto, Portugal

10:15 - 10:30

IL-27Ra signaling: key regulator of immunopathology in influenza infection

Francesca Diane Liu - German Institute for Rheumatology research, Germany

10:30 - 11:00

Coffee Break

11:00 - 11:30

TRIM5 is an innate immune sensor for the capsid lattice of HIV-1 and other retroviruses

Jeremy Luban - University of Geneva, Switzerland

11:30 - 11:45

Adaptive signatures in primate APOBEC3G reveal ancient, pathogenic forms of Simian Immunodeficiency Virus

Alex Compton - Fred Hutchinson Cancer Research Center, USA

11:45 - 12:15

Balancing the Signaling Pathways Involved in the Interaction of Mycobacterium tuberculosis with the Host

Jean Pieters - University of Basel, Switzerland

12:15 - 12:30

A ricin-like lectin from Mycobacterium tuberculosis regulates immune responses

Andre Bafica - Federal University of Santa Catarina, Brazil

12:30 - 14:30

Poster Session and Lunch

14:30 - 18:45

Session 5: Cell Biology of the host- pathogen interaction

Session Chair Jonathan Howard - Cologne University, Germany

14:30-15:00

Location, Location, Location: Compartmentalized Translation As a Source of MHC Class I Peptide Ligands

Jonathan Yewdell - NIAID NIH, USA

15:00 - 15:15

Shigella targets the adaptive immune response by inducing cell death in B lymphocytes

Katharina Nothelfer - Institut Pasteur, INSERM U786, France

15:15 - 15:30

A DC receptor for damaged cells mediates cross-priming of CTL during vaccinia virus infection in mice

Salvador Iborra - CNIC, Spain

15:30 - 16:00

Chromatin remodeling and a type III interferon response upon Listeria infection

Pascale Cossart - Pasteur Institute, France

16:00 - 16:30

Coffee Break

16:30 - 17:00

NETs - from infection to autoimmunity

Arturo Zychlinsky - Max Planck Institute Berlin, Germany

17:00 - 17:15

Viral ligands reposition activating and inhibitory receptors at the T-cell immune synapse to enhance inhibitory signalling: a novel mechanism for immune escape

Marco Purbhoo - Imperial College London, UK

17:15 - 17:45

Toxoplasma and the mouse: a tale of the unexpected

Jonathan Howard - Cologne University, Germany

17:45 - 18:45

Keynote Session

Acute HIV-1 infection and the vaccine problem

Andrew McMichael - Weatherall Institute of Molecular Medicine, UK

18:45 - 23:00

CONFERENCE DINNER AND PARTY

 

 

Day 4 - Tuesday, 22 May 2012

09:00 - 13:15

Session 6: Molecular mechanisms of innate recognition

Session Chair Kate Fitzgerald - University of Massachusetts, USA

09:00 - 09:30

RNA silencing in defense, counter-defense and counter-counter-defense

David Baulcombe - University of Cambridge, UK

09:30 - 10:00

The Drosophila gut: a new paradigm for innate immunity?

Bruno Lemaitre - Polytechnical School of Lausanne, Switzerland

10:00 - 10:30

Caspase-11-dependent inflammasome activation by Gram-negative bacteria

Kate Fitzgerald - University of Massachusetts, USA

10:30 - 11:00

Coffee Break

11:00 - 11:30

HMGB1 immunogenicity requires Nlrp3 inflammasome activation and processing by caspase-1

Maya Saleh - McGill University, Canada

11:30 - 12:00

A new  role for the inflammasome in cellular defense

Lynda Stuart - Massachusetts General Hospital / Harvard Medical School, USA

12:00 - 12:15

GADD34 is necessary for type-I interferon production in response to dsRNA and Chikungunya virus infection

Philippe Pierre - CNRS, France

12:15 - 12:30

DNA-PK is a viral DNA sensor

Brian Ferguson - University of Cambridge, UK

12:30 - 12:45

Anthrax lethal toxin cleavage of Nlrp1 is required for activation of the inflammasome

Mahtab Moayeri - NIH/NIAID, USA

12:45 - 13:00

Dual Engagement of NLRP3 and AIM2 inflammasomes by hemozoin-complexed DNA during malaria infection

Parisa Kalantari - University of Massachusetts Medical School, USA

13:00 - 13:15

Closing remarks - Conference Ends