Quality Control – From Molecules to Organelles

B. Bukau, J. Diffley, M. Hentze

EMBL Heidelberg, Germany

Wednesday 19 September - Saturday 22 September 2012

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Final Programme

The most up to date final programme can be see in the PDF download here

 

 

Wednesday, 19 September 2012
15:00-17:00

Arrival & Registration

17:15-17:30

Introductory Remarks
Bernd Bukau, University of Heidelberg, Germany

17:30-20:05

Keynote Talks

17:30-18:15

Double-Strand Break Repair: Regulation by SUMO and Homology Search
Stefan Jentsch, Max Planck Institute of Biochemistry, Germany

Session Chair: John Diffley, Cancer Research UK, United Kingdom

18:15-19:00

mRNA Quality Control: Insights into the Mechanism of Nonsense-mediated mRNA Decay
Elisa Izaurralde, Max Planck Institute for Developmental Biology, Germany

Session Chair: Matthias Hentze, EMBL Heidelberg, Germany

19:00-19:20 Coffee Break
19:20-20:05

A Ribosome-Bound Quality Control Complex Triggers Degradation of Nascent Peptides and Signals Translation Stress kindly sponsored by Open Biology
Jonathan Weissman, University of California, USA

Session Chair: Bernd Bukau, University of Heidelberg, Germany

20:05-21:30

Dinner

21:30-23:00 Roof Top Lounge
 

 

 

Thursday, 20 September 2012
09:00-12:30 Session 1: Quality control of genomic information

Chair: Stefan Jentsch, Max Planck Institute of Biochemistry, Germany

09:00-09:30

Guarding the Genome: Centromeres, Aneupoidy and Tumorigenesis
Don W. Cleveland, Ludwig Institute for Cancer Research, USA

09:30-10:00

Erroneous progression of restarted replication forks
Tony Carr, CanceGenome Damage and Stability Centre, University of Sussex, United Kingdom

10:00-10:15

Induction of a G1-S checkpoint in fission yeast
Beata Grallert, OUS, Institute for Cancer Research, Norway

10:15-10:30

Epigenetic control of DNA replication dynamics in mammals
Corella Casas-Delucchi, TU Darmstadt, Germany

10:30-11:00

Coffee Break

 

Session 1 Continued
Chair: Don W. Cleveland, Ludwig Institute for Cancer Research, USA

11:00-11:30

Quality control during cell division: the kinetochore version
Andrea Musacchio, Max-Planck Institute of Molecular Physiology, Germany

11:30-12:00

Transcription and R-loop mediated genome instability
Andrés Aguilera, Andalusian Molecular Biology and Regenerative Medicine Centre, Spain - CABIMER-Universidad de Sevilla, Spain

12:00-12:15

Non-coding telomeric RNA (TERRA) must be tightly regulated to prevent premature senescence
Brian Luke, University of Heidelberg, ZMBH, Germany

12:15-12:30

Regulation of replication initiation by Treslin/ticrr (vertebrate Sld3) and its novel binding partner MTBP
Dominik Boos, Cancer Research UK, United Kingdom

12:30-14:00

Lunch

14:00-18:00

Session 2: Quality control of transcription and RNA
Chair: Elena Conti, Max Planck Institute of Biochemistry, Germany

14:00-14:30

Structure-function analysis of quality control in mRNA biogenesis
Patrick Cramer, University of Munich, Germany

14:30-15:00

Ubiquitylation and Degradation of Elongating RNA Polymerase II: The Last Resort
Jesper Svejstrup, Cancer Research UK, United Kingdom

15:00-15:15

Sirt7 adapts RNA polymerase I activity to cellular stress
Renate Voit, German Cancer Research Center, Germany

15:15-15:30 CWC22 Connects pre-mRNA Splicing and Exon Junction Complex Assembly
Niels Gehring, University of Cologne, Germany
15:30-15:45

Selective autophagy mediates homeostatic degradation of DICER and AGO2 and regulates miRNA activity
Derrick Gibbings, University of Ottawa, Canada

15:45-16:15

Coffee break

 

Session 2 Continued
Chair: Patrick Cramer, University of Munich, Germany

16:15-16:45

RNase II-family members and their crucial role in Processing, Degradation, and Quality Control of RNAs
Cecília M. Arraiano, ITQB-Universidade Nova de Lisboa, Portugal

16:45-17:15

Regulated 3’ end processing – Implications for the control of blood coagulation, innate immunity and tumor spread
Andreas Kulozik, University of Heidelberg, Germany

17:15-17:45

Mechanisms of RNA degradation: the 3'-5' exosome complex
Elena Conti, Max Planck Institute of Biochemistry, Germany

17:45-18:00

Stress-induced degradation of newly synthesized polypeptides is mediated by ribosome-associated RACK1/JNK/eEF1A2 complex
Valentina Gandin, McGill University, Lady Davis Institute, Canada

18:00-20:00

Poster Session 1 - odd numbers

20:00-21:30

Dinner

21:30-00:00

After dinner drinks in the EMBL Advanced Training Centre Roof Top Lounge

 

 

Friday, 21 September 2012
09:00-12:30

Session 3: Quality control of translation and proteins in the cytsosol
Chair: Judith Frydman, Stanford University, USA

09:00-09:30

Angiogenin, tRNA and Amyotrophic Lateral Sclerosis
Paul Anderson, Harvard University, USA

09:30-10:00

Observation of mRNA Surveillance in Living Yeast by Ribosome Profiling
Rachel Green, Johns Hopkins University School of Medicine, USA

10:00-10:15

Protein quality control systems coupled with No-Go and Non-Stop mRNA surveillance in yeast
Toshifumi Inada, Tohoku University, Japan

10:15-10:30

Listerin/Ltn1, an E3 ligase implicated in neurodegeneration, mediates a novel pathway of cytoplasmic protein quality control
Claudio Joazeiro, The Scripps Research Institute, United States of America

10:30-11:00 Coffee Break
  Session 3 Continued
Chair: Anne Bertolotti, MRC Laboratory of Molecular Biology, United Kingdom
11:00-11:30

Principles of cotranslational ubiquitination and quality control at the ribosome
Judith Frydman, Stanford University, USA

11:30-12:00 Aneuploidy causes proteotoxic stress
Angelika B. Amon, Koch Institute for Integrative Cancer Research, HHMI, MIT, USA
12:00-12:15

A novel approach towards recovery of function of mutant proteins by slowing down translation
Michael Sherman, Boston University, United States of America

12:15-12:30

Molecular chaperones and stress-inducible protein sorting factors coordinate the spatio-temporal distribution of protein aggregates
Liliana Malinovska, Max Planck Institute of Molecular Cell Biology and Genetics, Germany

12:30-14:00 Lunch
14:00-18:00

Session 4: Protein Quality Control in the ER and protein degradation
Chair: Jennifer Lippincott-Schwartz, NICHD, USA

14:00-14:30

Regulation and structure of a novel AAA+/ubiquitin ligase protein, mysterin
Kaz Nagata, Kyoto Sangyo University, Japan

14:30-15:00

The HRD ubiquitin ligase contributes to ER-homeostasis by virtue of its holdase function
Thomas Sommer, MDC Berlin, Germany

15:00-15:15

Ubiquitin-Dependent Intramembrane Rhomboid Protease Promotes ERAD of Membrane Proteins
Marius Lemberg, Heidelberg University, Germany

15:15-15:30 RedOx visualization by Fluorescence Lifetime Imaging reveals stability of the ER oxidative milieu

Edward Avezov, University of Cambridge, United Kingdom

15:30-15:45

RNA Surveillance is Required for Endoplasmic Reticulum Homeostasis
Kenjiro Sakaki, Tokyo Women's Medical University, Japan

15:45-16:15 Coffee Break
  Session 4 Continued
Chair: Kaz Nagata, Kyoto Sangyo University, Japan
16:15-16:45

Surviving proteasome inhibition
Anne Bertolotti, MRC Laboratory of Molecular Biology, United Kingdom

16:45-17:15

Autophagic turnover of proteins and organelles
Jennifer Lippincott-Schwartz, NICHD, USA

17:15-17:45

Ubiquitin and autophagy networks in human diseases
Ivan Dikic, Goethe University, Frankfurt, Germany

17:45-18:00

Reprogramming of an ubiquitin ligase reveals insight into the ubiquitin code
Hermann-Josef Meyer, University of California, Berkeley, Molecular & Cell Biology, United States of America

18:00 - 18:15

The Role of ERp44 in Maturation of Serotonin Transporter Protein,
Fusun Kilic, University of Arkansas for Medical Sciences, USA 

18:15-20:00

Poster Session 2 - even numbers

20:00-21:30

Dinner

21:30-00:00

Party with Band Fatma2Soul

 

 

Saturday, 22 September 2012
09:00-12:30

Session 5 Caperone networks and stress responses
Chair: Rick Morimoto, Northwestern University, USA

09:00-09:30

Chaperone mechanisms in protein folding and proteostasis
F. Ulrich Hartl, Max Planck Institute of Biochemistry, Martinsried, Germany

09:30-09:45

DNAJB6, a non-canonical molecular chaperone that delays peptide seeding in aggregation diseases
Harm Kampinga, UMCG, The Netherlands

09:45-10:00

Metazoan Hsp70 machines use Hsp110 to power protein disaggregation
Heike Rampelt, University of Heidelberg, Germany

10:00-10:15

Triaging Hsp70-associated proteins in the eukaryotic cytoplasm
Claes Andréasson, Stockholm University, Sweden

10:15-10:30

Disruption of Regulatory Elements in Hsp100 Disaggregase Unleashes Toxic Hyperactivity and Partial Independence from Hsp70
Krzysztof Liberek, University of Gdansk, Poland

10:30-11:00 Coffee Break
  Session 5 Continued
Chair: Angelika B. Amon, Koch Institute for Integrative Cancer Research, HHMI, MIT, USA
11:00-11:30

Shared and Unique Targets of Mammalian Heat Shock Factors in Cell Stress
Lea Sistonen, Åbo Akademi University, Finland

11:30-12:00

The UPRER is a Cell Non-Autonomous Regulator of Stress Resistance and Longevity
Andy Dillin, Salk Institute, USA

12:00-12:15

Mitochondrial malfunction and autophagy - a double-edged sword
Nuno Raimundo, Yale School of Medicine, United States of America

12:15-12:45

Proteostasis - Regulating Proteome Stability in Biology, Aging, and Disease
Rick Morimoto, Northwestern University, USA

12:45-13:00

Poster Prize announced by John Diffley, Cancer Research UK, United Kingdom

13:00-13:15

Closing Remarks: John Diffley, Cancer Research UK, United Kingdom

13:15-13:30 Packed Lunch
   
  Free afternoon in Heidelberg