Quality Control – From Molecules to Organelles

Arrival & Registration

Introductory Remarks
Bernd Bukau, University of Heidelberg, Germany

Keynote Talks

Double-Strand Break Repair: Regulation by SUMO and Homology Search
Stefan Jentsch, Max Planck Institute of Biochemistry, Germany

Session Chair: John Diffley, Cancer Research UK, United Kingdom

mRNA Quality Control: Insights into the Mechanism of Nonsense-mediated mRNA Decay
Elisa Izaurralde, Max Planck Institute for Developmental Biology, Germany

Session Chair: Matthias Hentze, EMBL Heidelberg, Germany

A Ribosome-Bound Quality Control Complex Triggers Degradation of Nascent Peptides and Signals Translation Stress kindly sponsored by Open Biology
Jonathan Weissman, University of California, USA

Session Chair: Bernd Bukau, University of Heidelberg, Germany

Dinner

Chair: Stefan Jentsch, Max Planck Institute of Biochemistry, Germany

Guarding the Genome: Centromeres, Aneupoidy and Tumorigenesis
Don W. Cleveland, Ludwig Institute for Cancer Research, USA

Erroneous progression of restarted replication forks
Tony Carr, CanceGenome Damage and Stability Centre, University of Sussex, United Kingdom

Induction of a G1-S checkpoint in fission yeast
Beata Grallert, OUS, Institute for Cancer Research, Norway

Epigenetic control of DNA replication dynamics in mammals
Corella Casas-Delucchi, TU Darmstadt, Germany

Coffee Break

Session 1 Continued
Chair: Don W. Cleveland, Ludwig Institute for Cancer Research, USA

Quality control during cell division: the kinetochore version
Andrea Musacchio, Max-Planck Institute of Molecular Physiology, Germany

Transcription and R-loop mediated genome instability
Andrés Aguilera, Andalusian Molecular Biology and Regenerative Medicine Centre, Spain - CABIMER-Universidad de Sevilla, Spain

Non-coding telomeric RNA (TERRA) must be tightly regulated to prevent premature senescence
Brian Luke, University of Heidelberg, ZMBH, Germany

Regulation of replication initiation by Treslin/ticrr (vertebrate Sld3) and its novel binding partner MTBP
Dominik Boos, Cancer Research UK, United Kingdom

Lunch

Session 2: Quality control of transcription and RNA
Chair: Elena Conti, Max Planck Institute of Biochemistry, Germany

Structure-function analysis of quality control in mRNA biogenesis
Patrick Cramer, University of Munich, Germany

Ubiquitylation and Degradation of Elongating RNA Polymerase II: The Last Resort
Jesper Svejstrup, Cancer Research UK, United Kingdom

Sirt7 adapts RNA polymerase I activity to cellular stress
Renate Voit, German Cancer Research Center, Germany

Selective autophagy mediates homeostatic degradation of DICER and AGO2 and regulates miRNA activity
Derrick Gibbings, University of Ottawa, Canada

Coffee break

Session 2 Continued
Chair: Patrick Cramer, University of Munich, Germany

RNase II-family members and their crucial role in Processing, Degradation, and Quality Control of RNAs
Cecília M. Arraiano, ITQB-Universidade Nova de Lisboa, Portugal

Regulated 3’ end processing – Implications for the control of blood coagulation, innate immunity and tumor spread
Andreas Kulozik, University of Heidelberg, Germany

Mechanisms of RNA degradation: the 3'-5' exosome complex
Elena Conti, Max Planck Institute of Biochemistry, Germany

Stress-induced degradation of newly synthesized polypeptides is mediated by ribosome-associated RACK1/JNK/eEF1A2 complex
Valentina Gandin, McGill University, Lady Davis Institute, Canada

Poster Session 1 - odd numbers

Dinner

After dinner drinks in the EMBL Advanced Training Centre Roof Top Lounge

Session 3: Quality control of translation and proteins in the cytsosol
Chair: Judith Frydman, Stanford University, USA

Angiogenin, tRNA and Amyotrophic Lateral Sclerosis
Paul Anderson, Harvard University, USA

Observation of mRNA Surveillance in Living Yeast by Ribosome Profiling
Rachel Green, Johns Hopkins University School of Medicine, USA

Protein quality control systems coupled with No-Go and Non-Stop mRNA surveillance in yeast
Toshifumi Inada, Tohoku University, Japan

Listerin/Ltn1, an E3 ligase implicated in neurodegeneration, mediates a novel pathway of cytoplasmic protein quality control
Claudio Joazeiro, The Scripps Research Institute, United States of America

Principles of cotranslational ubiquitination and quality control at the ribosome
Judith Frydman, Stanford University, USA

A novel approach towards recovery of function of mutant proteins by slowing down translation
Michael Sherman, Boston University, United States of America

Molecular chaperones and stress-inducible protein sorting factors coordinate the spatio-temporal distribution of protein aggregates
Liliana Malinovska, Max Planck Institute of Molecular Cell Biology and Genetics, Germany

Session 4: Protein Quality Control in the ER and protein degradation
Chair: Jennifer Lippincott-Schwartz, NICHD, USA

Regulation and structure of a novel AAA+/ubiquitin ligase protein, mysterin
Kaz Nagata, Kyoto Sangyo University, Japan

The HRD ubiquitin ligase contributes to ER-homeostasis by virtue of its holdase function
Thomas Sommer, MDC Berlin, Germany

Ubiquitin-Dependent Intramembrane Rhomboid Protease Promotes ERAD of Membrane Proteins
Marius Lemberg, Heidelberg University, Germany

Edward Avezov, University of Cambridge, United Kingdom

RNA Surveillance is Required for Endoplasmic Reticulum Homeostasis
Kenjiro Sakaki, Tokyo Women's Medical University, Japan

Surviving proteasome inhibition
Anne Bertolotti, MRC Laboratory of Molecular Biology, United Kingdom

Autophagic turnover of proteins and organelles
Jennifer Lippincott-Schwartz, NICHD, USA

Ubiquitin and autophagy networks in human diseases
Ivan Dikic, Goethe University, Frankfurt, Germany

Reprogramming of an ubiquitin ligase reveals insight into the ubiquitin code
Hermann-Josef Meyer, University of California, Berkeley, Molecular & Cell Biology, United States of America

The Role of ERp44 in Maturation of Serotonin Transporter Protein,
Fusun Kilic, University of Arkansas for Medical Sciences, USA 

Poster Session 2 - even numbers

Dinner

Party with Band Fatma2Soul

Session 5 Caperone networks and stress responses
Chair: Rick Morimoto, Northwestern University, USA

Chaperone mechanisms in protein folding and proteostasis
F. Ulrich Hartl, Max Planck Institute of Biochemistry, Martinsried, Germany

DNAJB6, a non-canonical molecular chaperone that delays peptide seeding in aggregation diseases
Harm Kampinga, UMCG, The Netherlands

Metazoan Hsp70 machines use Hsp110 to power protein disaggregation
Heike Rampelt, University of Heidelberg, Germany

Triaging Hsp70-associated proteins in the eukaryotic cytoplasm
Claes Andréasson, Stockholm University, Sweden

Disruption of Regulatory Elements in Hsp100 Disaggregase Unleashes Toxic Hyperactivity and Partial Independence from Hsp70
Krzysztof Liberek, University of Gdansk, Poland

Shared and Unique Targets of Mammalian Heat Shock Factors in Cell Stress
Lea Sistonen, Åbo Akademi University, Finland

The UPRER is a Cell Non-Autonomous Regulator of Stress Resistance and Longevity
Andy Dillin, Salk Institute, USA

Mitochondrial malfunction and autophagy - a double-edged sword
Nuno Raimundo, Yale School of Medicine, United States of America

Proteostasis - Regulating Proteome Stability in Biology, Aging, and Disease
Rick Morimoto, Northwestern University, USA

Poster Prize announced by John Diffley, Cancer Research UK, United Kingdom

Closing Remarks: John Diffley, Cancer Research UK, United Kingdom