The Complex Life of mRNA

D. Tollervey, J. Steitz, N. Sonenberg, A. Ephrussi

EMBL Heidelberg, Germany

Sunday 7 October - Wednesday 10 October 2012

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Programme

The latest version of the programme with the list of posters is available for downloading:  Download pdf version.

 

Day 1 - Sunday, 7 October 2012
Time Speaker Title
16:00 - 17:45 Arrival and Registration
17:45 - 19:00 BUFFET DINNER
19:00 - 19:15 Welcome
19:15 -20:00 Keynote Talk : Elena Conti, Max Planck Institute of Biochemistry, Martinsried, Germany

kindly sponsored by Open Biology

Mechanisms of 3'->5' RNA degradation
20:00 - 20:45 Keynote Talk : Steven L. McKnight, UT Southwestern Medical Center, Dallas, USA Involvement of Low Complexity Polypeptide Sequences in the Formation of RNA Granules
20:45 - 21:30 Keynote Talk: Nikolaus Rajewsky, Max-Delbrück Center for Molecular Medicine, Berlin, Germany Post-transcriptional gene regulation by small RNAs and RNA binding proteins
21:30 - 23:00 Drinks and Poster "Sneak Preview"

 

 
Day 2 - Monday, 8 October 2012
Time Speaker Title
09:00- 13:10 Session 2 - RNA Surveillance and Decay
09:00 -09:25 Joan A. Steitz, Molecular Biophysics and Biochemistry; HHMI at Yale University, USA Viral noncoding RNPs
09:25 - 09:50 Roy Parker, University of Colorado/HHMI, USA Eukaryotic mRNA Turnover
09:50 - 10:15 Torben Heick Jensen, Aarhus University, Denmark Production and destruction of RNA in human nuclei
10:15- 10:45 COFFEE BREAK
10:45 - 11:10 Lynne Elizabeth Maquat, University of Rochester, USA Tales from the cellular underworld: mRNA decay
11:10 – 11:25 Nele Hug,MRC HGU, IGMM, United Kingdom DHX34 activates NMD by promoting the transition from the SURF to the DECID complex
11:25 - 11:50 Jens Lykke-Andersen, University of California, San Diego, USA Reining in the mRNA decay enzymes: Proteolytic control of decapping
11:50 - 12:05 Dominique Gagliardi, CNRS- University of Strasbourg, France Uridylation prevents the formation of aberrant mRNAs by protecting deadenylated mRNA 3' ends
12:05 - 12:30 David Tollervey, University of Edinburgh, United Kingdom Non-coding RNAs and mRNAs: Brothers separated at birth?
12:30 - 12:45 Cátia Igreja, MPI for Developmental Biology Tuebingen, Germany d4E-T: a eIF4E-binding protein that promotes deadenylation-dependent decay of target mRNAs to control cell proliferation
12:45 - 13:10 Britt A. Glaunsinger, University of California, Berkeley, USA Virus-host interplay leads to widespread mRNA destruction
13:10 - 16:00  LUNCH and POSTER SESSION 1
16:00 - 19:20 Session 3 - Mechanics and Regulation of Translation  
16:00 - 16:25 Rachel Green, Johns Hopkins University, Baltimore, USA mRNA surveillance is driven by translation
16:25 - 16:40 Herve Le Hir,IBENS, France CLIP-seq of the DEAD-box RNA helicase eIF4AIII reveals transcriptome-wide mapping of the exon junction complex in human
16:40 – 17:05 Matthias W. Hentze, EMBL Heidelberg, Germany RNA meets metabolism: from mRNA interactomes to REM networks
17:05 - 17:35 COFFEE BREAK
17:35 - 18:00 Alan G. Hinnebusch, National Institutes of Health Bethesda, USA Molecular mechanisms of ribosomal scanning and AUG selection: where to begin?
18:00 - 18:15 Oscar Llorca, Spanish National Research Council-CSIC, Spain The cryo-EM structure of the UPF-EJC complex shows how UPF1 is poised to unwind the 3' end of a PTC-containing mRNP
18:15 - 18:40 Joel Richter, University of Massachusetts, Worcester, USA Translational control of higher brain function
18:40 - 18:55 Eleen Shum, UC San Diego, United States of America Physiological Role of NMD in Neuronal Development In Vivo
18:55 - 19:20 Nenad Ban, ETH Zürich, Switzerland Crystal structures of the eukaryotic ribosome and insights into the regulation and initiation of protein synthesis
19:20 - 21:00 DINNER
21:00 - 23:00 Drinks in the ATC Foyer and Roof Top Lounge and poster viewing
 
 
Day 3 - Tuesday, 9 October 2012
Time Speaker Title
09:00 -12:40 Session 4 - Epigenetics and Transcription
09:00 - 09:25 Patrick Cramer, Ludwig-Maximilians-University München, Germany Structure-guided dynamic transcriptome analysis elucidates the mRNA life cycle
09:25- 09:40 Domenico Libri, CNRS - CGM, France Road-block termination defines a new class of cryptic transcripts
09:40- 10:05 Alberto Kornblihtt, University of Buenos Aires, Argentina Chromatin and transcription regulate alternative splicing
10:05 – 10:20 Odil Porrua Fuerte, Centre de Genetique Moleculaire-CNRS, France “Catching up” with polymerase: the mechanisms of Sen1-dependent termination
10:20 – 10:35 Markus Landthaler, Max-Delbrück-Center for Molecular Medicine, Germany The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts
10:35 - 11:05 COFFEE BREAK
11:05 – 11:30 Nicholas J. Proudfoot, University of Oxford, United Kingdom Ending the message in eukaryotes: Gene loops, R-loops and noncoding RNA
11:30- 11:45 David Brow, University of Wisconsin-Madison, United States of America Global regulatory functions of Sen1-dependent Pol II termination factors
11:45- 12:10 Karla Neugebauer, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany Splicing on chromatin
12:10 – 12:25 Daniel Zenklusen, Université de Montréal, Canada Single cell analysis reveals aspects of antisense RNA regulation and mode of action in PHO84 transcription repression
12:25 – 12:40 Silvia Rouskin, UCSF, United States of America Genome-wide measurement of RNA structure in vivo
12:40 - 15:30 LUNCH and POSTER SESSION 2
15:30 - 17:40 Session 5 - Pre-mRNA Processing
15:30 - 15:55 James L. Manley, Columbia University, New York, USA Processing of mRNA precursors and links to human disease
15:55 - 16:20 Gideon Dreyfuss, University of Pennsylvania/HHMI, USA TELESCRIPTING: A New Dimension to mRNA Regulation
16:20 -16:35 Valerie Hilgers, UC Berkeley, United States of America ELAV mediates neuronal‑specific 3’ UTR extension by suppressing proximal polyadenylation
16:35 -17:00 Jernej Ule, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom How competition between RNA-binding proteins for overlapping binding sites controls splicing decisions
17:00 -17:15 Anna-Lena Steckelberg, Institute for Genetics, University of Cologne, Germany CWC22 Connects Pre-mRNA Splicing and Exon Junction Complex Assembly
17:15 - 17:40 Melissa J. Moore, UMass Medical School/HHMI, USA Pre-mRNA processing and mRNA metabolism
17:40 -18:00 Pre-dinner drinks
18:00 -20:00 DINNER
20:00 - 23:00 Drinks in the ATC Foyer and Roof Top Lounge and poster viewing
 
 
Day 4 - Wednesday, 10 October 2012
Time Speaker Title
09:00 -12:35 Session 6 - miRNA Function
09:00 -09:25 Nahum Sonenberg, McGill University, Canada Structural insights into miRISC recruitment of the CCR4-NOT complex
09:25 - 09:50 Helge Grosshans, Friedrich Miescher Institute, Basel, Switzerland Function and Regulation of MicroRNAs
09:50 – 10:05 Bridlin Barckmann, IGH Institute of Human Genetics, France The piRNA pathway and its role in the regulation of maternal mRNAs in the Drosophila early embryo
10:05- 10:30 Witold Filipowicz, Friedrich Miescher Institute, Basel, Switzerland Regulation of miRNA‑mediated Repression and miRNA Metabolism in Mammalian Cells
10:30 - 11:00 COFFEE BREAK
11:00- 11:25 Mikiko C. Siomi, Keio University, Tokyo, Japan Biogenesis and function of PIWI-interacting RNA in Drosophila
11:25- 11:40 Alena Shkumatava, Whitehead Institute/MIT, United States of America miRNA-mediated regulation of the cyrano lincRNA is a non‑canonical pathway essential for early vertebrate development
11:40 – 12:05 Elisa Izaurralde, Max Planck Institute for Developmental Biology, Tübingen, Germany Evolutionary plasticity of the protein interaction network that regulates mRNA stability
12:05 - 12:20 David Weinberg,Whitehead Institute / MIT, United States of America Structure of yeast Argonaute with guide RNA
12:20 – 12:35 Astrid Haase, Cold Spring Harbor Laboratory, United States of America The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis
12:35 - 15:30 LUNCH and POSTER SESSION 3
15:30 - 18:30 Session 7 - mRNA Export and Localization
15:30 - 15:55 Karsten Weis, University of California, Berkeley, USA Regulation of mRNA export and decay
15:55 - 16:10 Erin Osborne Nishimura,University of North Carolina, United States of America Blastomere-specific transcriptome profiling after the first embryonic division
16:10 - 16:25 Fulvia Bono, Max Planck for Developmental Biology, Germany Structural studies of a minimal eIF4E‑Cup complex
16:25- 16:55 COFFEE BREAK
16:55 - 17:10 Philipp Kimmig, UCSF, United States of America The Unfolded Protein Response in Fission Yeast  Modulates Stability of Select mRNAs to Maintain Protein Homeostasis
17:10 - 17:25 Dierk Niessing, Helmholtz Zentrum München, Germany Insights into biogenesis and localization of mRNPs from in vitro reconstitution experiments
17:25 - 17:50 Anne Ephrussi, EMBL Heidelberg, Germany Adaptation of the organism to its environment: fine-tuning RNA localization dynamics
17:50 - 18:15 Robert H. Singer, Albert Einstein College of Medicine, New York, USA Following Single mRNAs from Birth to Death: A Systems Approach
18:15 - 18:30 Closing remarks
18:30 -00:00 BANQUET DINNER and PARTY