The Complex Life of mRNA
D. Tollervey, J. Steitz, N. Sonenberg, A. Ephrussi
EMBL Heidelberg, Germany
Sunday 7 October - Wednesday 10 October 2012
Programme
The latest version of the programme with the list of posters is available for downloading: Download pdf version.
| Time | Speaker | Title |
|---|---|---|
| 16:00 - 17:45 | Arrival and Registration | |
| 17:45 - 19:00 | BUFFET DINNER | |
| 19:00 - 19:15 | Welcome | |
| 19:15 -20:00 |
Keynote Talk : Elena Conti, Max Planck Institute of Biochemistry, Martinsried, Germany
kindly sponsored by Open Biology |
Mechanisms of 3'->5' RNA degradation |
| 20:00 - 20:45 | Keynote Talk : Steven L. McKnight, UT Southwestern Medical Center, Dallas, USA | Involvement of Low Complexity Polypeptide Sequences in the Formation of RNA Granules |
| 20:45 - 21:30 | Keynote Talk: Nikolaus Rajewsky, Max-Delbrück Center for Molecular Medicine, Berlin, Germany | Post-transcriptional gene regulation by small RNAs and RNA binding proteins |
| 21:30 - 23:00 | Drinks and Poster "Sneak Preview" | |
| Time | Speaker | Title |
|---|---|---|
| 09:00- 13:10 | Session 2 - RNA Surveillance and Decay | |
| 09:00 -09:25 | Joan A. Steitz, Molecular Biophysics and Biochemistry; HHMI at Yale University, USA | Viral noncoding RNPs |
| 09:25 - 09:50 | Roy Parker, University of Colorado/HHMI, USA | Eukaryotic mRNA Turnover |
| 09:50 - 10:15 | Torben Heick Jensen, Aarhus University, Denmark | Production and destruction of RNA in human nuclei |
| 10:15- 10:45 | COFFEE BREAK | |
| 10:45 - 11:10 | Lynne Elizabeth Maquat, University of Rochester, USA | Tales from the cellular underworld: mRNA decay |
| 11:10 – 11:25 | Nele Hug,MRC HGU, IGMM, United Kingdom | DHX34 activates NMD by promoting the transition from the SURF to the DECID complex |
| 11:25 - 11:50 | Jens Lykke-Andersen, University of California, San Diego, USA | Reining in the mRNA decay enzymes: Proteolytic control of decapping |
| 11:50 - 12:05 | Dominique Gagliardi, CNRS- University of Strasbourg, France | Uridylation prevents the formation of aberrant mRNAs by protecting deadenylated mRNA 3' ends |
| 12:05 - 12:30 | David Tollervey, University of Edinburgh, United Kingdom | Non-coding RNAs and mRNAs: Brothers separated at birth? |
| 12:30 - 12:45 | Cátia Igreja, MPI for Developmental Biology Tuebingen, Germany | d4E-T: a eIF4E-binding protein that promotes deadenylation-dependent decay of target mRNAs to control cell proliferation |
| 12:45 - 13:10 | Britt A. Glaunsinger, University of California, Berkeley, USA | Virus-host interplay leads to widespread mRNA destruction |
| 13:10 - 16:00 | LUNCH and POSTER SESSION 1 | |
| 16:00 - 19:20 | Session 3 - Mechanics and Regulation of Translation | |
| 16:00 - 16:25 | Rachel Green, Johns Hopkins University, Baltimore, USA | mRNA surveillance is driven by translation |
| 16:25 - 16:40 | Herve Le Hir,IBENS, France | CLIP-seq of the DEAD-box RNA helicase eIF4AIII reveals transcriptome-wide mapping of the exon junction complex in human |
| 16:40 – 17:05 | Matthias W. Hentze, EMBL Heidelberg, Germany | RNA meets metabolism: from mRNA interactomes to REM networks |
| 17:05 - 17:35 | COFFEE BREAK | |
| 17:35 - 18:00 | Alan G. Hinnebusch, National Institutes of Health Bethesda, USA | Molecular mechanisms of ribosomal scanning and AUG selection: where to begin? |
| 18:00 - 18:15 | Oscar Llorca, Spanish National Research Council-CSIC, Spain | The cryo-EM structure of the UPF-EJC complex shows how UPF1 is poised to unwind the 3' end of a PTC-containing mRNP |
| 18:15 - 18:40 | Joel Richter, University of Massachusetts, Worcester, USA | Translational control of higher brain function |
| 18:40 - 18:55 | Eleen Shum, UC San Diego, United States of America | Physiological Role of NMD in Neuronal Development In Vivo |
| 18:55 - 19:20 | Nenad Ban, ETH Zürich, Switzerland | Crystal structures of the eukaryotic ribosome and insights into the regulation and initiation of protein synthesis |
| 19:20 - 21:00 | DINNER | |
| 21:00 - 23:00 | Drinks in the ATC Foyer and Roof Top Lounge and poster viewing | |
| Time | Speaker | Title |
|---|---|---|
| 09:00 -12:40 | Session 4 - Epigenetics and Transcription | |
| 09:00 - 09:25 | Patrick Cramer, Ludwig-Maximilians-University München, Germany | Structure-guided dynamic transcriptome analysis elucidates the mRNA life cycle |
| 09:25- 09:40 | Domenico Libri, CNRS - CGM, France | Road-block termination defines a new class of cryptic transcripts |
| 09:40- 10:05 | Alberto Kornblihtt, University of Buenos Aires, Argentina | Chromatin and transcription regulate alternative splicing |
| 10:05 – 10:20 | Odil Porrua Fuerte, Centre de Genetique Moleculaire-CNRS, France | “Catching up” with polymerase: the mechanisms of Sen1-dependent termination |
| 10:20 – 10:35 | Markus Landthaler, Max-Delbrück-Center for Molecular Medicine, Germany | The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts |
| 10:35 - 11:05 | COFFEE BREAK | |
| 11:05 – 11:30 | Nicholas J. Proudfoot, University of Oxford, United Kingdom | Ending the message in eukaryotes: Gene loops, R-loops and noncoding RNA |
| 11:30- 11:45 | David Brow, University of Wisconsin-Madison, United States of America | Global regulatory functions of Sen1-dependent Pol II termination factors |
| 11:45- 12:10 | Karla Neugebauer, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany | Splicing on chromatin |
| 12:10 – 12:25 | Daniel Zenklusen, Université de Montréal, Canada | Single cell analysis reveals aspects of antisense RNA regulation and mode of action in PHO84 transcription repression |
| 12:25 – 12:40 | Silvia Rouskin, UCSF, United States of America | Genome-wide measurement of RNA structure in vivo |
| 12:40 - 15:30 | LUNCH and POSTER SESSION 2 | |
| 15:30 - 17:40 | Session 5 - Pre-mRNA Processing | |
| 15:30 - 15:55 | James L. Manley, Columbia University, New York, USA | Processing of mRNA precursors and links to human disease |
| 15:55 - 16:20 | Gideon Dreyfuss, University of Pennsylvania/HHMI, USA | TELESCRIPTING: A New Dimension to mRNA Regulation |
| 16:20 -16:35 | Valerie Hilgers, UC Berkeley, United States of America | ELAV mediates neuronal‑specific 3’ UTR extension by suppressing proximal polyadenylation |
| 16:35 -17:00 | Jernej Ule, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom | How competition between RNA-binding proteins for overlapping binding sites controls splicing decisions |
| 17:00 -17:15 | Anna-Lena Steckelberg, Institute for Genetics, University of Cologne, Germany | CWC22 Connects Pre-mRNA Splicing and Exon Junction Complex Assembly |
| 17:15 - 17:40 | Melissa J. Moore, UMass Medical School/HHMI, USA | Pre-mRNA processing and mRNA metabolism |
| 17:40 -18:00 | Pre-dinner drinks | |
| 18:00 -20:00 | DINNER | |
| 20:00 - 23:00 | Drinks in the ATC Foyer and Roof Top Lounge and poster viewing | |
| Time | Speaker | Title |
|---|---|---|
| 09:00 -12:35 | Session 6 - miRNA Function | |
| 09:00 -09:25 | Nahum Sonenberg, McGill University, Canada | Structural insights into miRISC recruitment of the CCR4-NOT complex |
| 09:25 - 09:50 | Helge Grosshans, Friedrich Miescher Institute, Basel, Switzerland | Function and Regulation of MicroRNAs |
| 09:50 – 10:05 | Bridlin Barckmann, IGH Institute of Human Genetics, France | The piRNA pathway and its role in the regulation of maternal mRNAs in the Drosophila early embryo |
| 10:05- 10:30 | Witold Filipowicz, Friedrich Miescher Institute, Basel, Switzerland | Regulation of miRNA‑mediated Repression and miRNA Metabolism in Mammalian Cells |
| 10:30 - 11:00 | COFFEE BREAK | |
| 11:00- 11:25 | Mikiko C. Siomi, Keio University, Tokyo, Japan | Biogenesis and function of PIWI-interacting RNA in Drosophila |
| 11:25- 11:40 | Alena Shkumatava, Whitehead Institute/MIT, United States of America | miRNA-mediated regulation of the cyrano lincRNA is a non‑canonical pathway essential for early vertebrate development |
| 11:40 – 12:05 | Elisa Izaurralde, Max Planck Institute for Developmental Biology, Tübingen, Germany | Evolutionary plasticity of the protein interaction network that regulates mRNA stability |
| 12:05 - 12:20 | David Weinberg,Whitehead Institute / MIT, United States of America | Structure of yeast Argonaute with guide RNA |
| 12:20 – 12:35 | Astrid Haase, Cold Spring Harbor Laboratory, United States of America | The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis |
| 12:35 - 15:30 | LUNCH and POSTER SESSION 3 | |
| 15:30 - 18:30 | Session 7 - mRNA Export and Localization | |
| 15:30 - 15:55 | Karsten Weis, University of California, Berkeley, USA | Regulation of mRNA export and decay |
| 15:55 - 16:10 | Erin Osborne Nishimura,University of North Carolina, United States of America | Blastomere-specific transcriptome profiling after the first embryonic division |
| 16:10 - 16:25 | Fulvia Bono, Max Planck for Developmental Biology, Germany | Structural studies of a minimal eIF4E‑Cup complex |
| 16:25- 16:55 | COFFEE BREAK | |
| 16:55 - 17:10 | Philipp Kimmig, UCSF, United States of America | The Unfolded Protein Response in Fission Yeast Modulates Stability of Select mRNAs to Maintain Protein Homeostasis |
| 17:10 - 17:25 | Dierk Niessing, Helmholtz Zentrum München, Germany | Insights into biogenesis and localization of mRNPs from in vitro reconstitution experiments |
| 17:25 - 17:50 | Anne Ephrussi, EMBL Heidelberg, Germany | Adaptation of the organism to its environment: fine-tuning RNA localization dynamics |
| 17:50 - 18:15 | Robert H. Singer, Albert Einstein College of Medicine, New York, USA | Following Single mRNAs from Birth to Death: A Systems Approach |
| 18:15 - 18:30 | Closing remarks | |
| 18:30 -00:00 | BANQUET DINNER and PARTY | |