Germline - Immortality through Totipotency

R. Lehmann, E. Heard, J. Rossant

EMBL Heidelberg, Germany

Saturday 13 October - Tuesday 16 October 2012

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Final Programme

Day 1 - Saturday 13 October 2012
15:00 - 17:20 Arrival & Registration
17:20 - 17:30 Welcome and Opening Session
Chair: Ruth Lehmann
17:30 - 18:20 Keynote Lecture: Induction of pluripotency by the female germline

John Gurdon, Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, United Kingdom
kindly sponsored by The Company of Biologists

18:20 - 18:45

Establishing pluripotency in the blastocyst

Janet Rossant, University of Toronto, Canada
18:45 - 19:10

Developmental Dynamics of X-Chromosome Inactivation in Mammals

Edith Heard, Institut Curie, France 
19:10 - 19:25

Selected Short Talk 1

Molecular determinants of histone retention in mouse and human spermatozoa

Antoine HFM Peters, Friedrich Miescher Institute for Biomedical Research (FMI), Switzerland
19:30 - 20:30 Dinner
20:30 - 22:30 After Dinner Drinks
 

 

Day 2 - Sunday 14 October 2012
  Session 1: From Single Cell to Multicellularity
Chair: Edith Heard
09:00 - 09:25 Symmetry breaking in mouse development

Takashi Hiiragi, EMBL, Germany

09:25 - 09:50 Epigenetic mechanisms of cell potency

Maria-Elena Torres-Padilla, The Institute of Genetics and Molecular and Cellular Biology, France  

09:50 - 10:05

Selected Short Talk 2

Early lineage specification in a marsupial

Stephen Frankenberg, University of Melbourne, Australia
10:05 - 10:30

Visualizing the mechanisms of spindle assembly and homologous chromosome segregation in mammalian oocytes

Jan Ellenberg, EMBL, Germany

10:30 - 11:00 Morning Coffee Break
11:00 - 11:25

Chromosome segregation in oocytes

Kim Nasmyth, University of Oxford, United Kingdom

11:25 - 11:40

Selected Short Talk 3

Protein aggregate fusion facilitates a switch between immortality and ageing

Miguel C Coelho, MPI-CBG, Germany
11:40 - 12:30 Keynote Lecture

Programming germ cells for totipotency and early mammalian development

Azim Surani, Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, United Kingdom

12:30 - 14:00 Lunch
  Session 2: Chromosomes and Chromatin
Chair: Janet Rossant
14:00 - 14:25 Chromatin Dynamics in Vertebrate Germlines

Bradley R. Cairns, University of Utah, USA  

14:25 - 14:50 C. elegans germ granules maintain germline fate and totipotency

Susan Strome, University of California Santa Cruz, USA  

14:50 - 15:15

The H3K27 demethylase Utx facilitates somatic and germ cell epigenetic reprogramming to pluripotency

Jacob Hanna, Weizmann Institute of Science, Israel

 

 

15:15 - 15:30 Selected Short Talk 4

Tex19 paralogs, two new members of mammalian Piwi protein family

Stephane Viville, IGBMC, France

15:30 - 16:00 Afternoon Coffee Break
16:00 - 16:25 Epigenetic inheritance from the oocyte

Déborah Bourc’his, INSERM, France  

16:25 - 16:50

Systems Biology of Stem Cells

Huck Hui NG, Genome Institute of Singapore, Singapore   
16:50 - 17:05 Selected Short Talk 5

DNA methylation establishment in mammalian oocytes is determined by transcription events

Gavin Kelsey, The Babraham Institute, United Kingdom
17:05 - 17:30 Fast Track Poster Presentation Session
17:30 - 19:30 Poster Session
19:30 - 20:30 Dinner
20:30 - 22:30 After Dinner Drinks
 

 

Day 3 - Monday 15 October 2012
  Session 3: Programming and Reprogramming
Chair: Bradley R. Cairns
09:00 - 09:25 Mechanisms of reprogramming to pluripotency

Katrin Plath, University of California, Los Angeles, USA  

09:25 - 09:50 Epigenetic Reprogramming in Mammalian Development

Wolf Reik, Babraham Institute, United Kingdom  

09:50 - 10:05 Selected Short Talk 6

Direct conversion of germ cells into specific somatic cell types

Baris Tursun, Max-Delbrück-Center, Germany
10:05 - 10:30

The cellular and molecular basis for planarian regeneration

Peter W. Reddien, Whitehead Institute, Massachusetts Institute of Technology, USA  
10:30 - 11:00 Morning Coffee Break
11:00 - 11:25

Protecting the Germline

Ruth Lehmann, New York University School of Medicine and HHMI, USA  
11:25 - 11:40 Selected Short Talk 7

The co-chaperone Shutdown defines a group of biogenesis factors essential for all piRNA populations in Drosophila

Daniel Olivieri, IMBA, Austria
11:40 - 12:30 Control of germ cell commitment in yeast

Keynote Lecture: Angelika Amon, The Koch Institute, Massachusetts Institute of Technology, USA  

12:30 - 14:00 Meet the Speaker Lunch
  Session 4: Context Matters
Chair: David C. Page
14:00 - 14:25 Epigenetic regulation of aging

Anne Brunet, Stanford University, USA  

14:25 - 14:50 Asymmetric chromosome segregation during stem cell division in Drosophila male germline

Yukiko Yamashita, University of Michigan, USA . 

14:50 - 15:15 Mechanisms of position-dependent specification of cell fates in preimplantation embryos

Hiroshi Sasaki, Kumamoto University, Japan  

15:15 - 15:45 Afternoon Coffee Break
15:45 - 16:10 Germline function in mice and men

Marty M. Matzuk, Baylor College of Medicine, USA  

16:10 - 16:25 Selected Short Talk 7

Physiological control of niche and stem cell establishment

Dana Gancz, Weizmann Institute of Science, Israel
16:25 - 16:45 Fast Track Poster Presentation Session
16:45 - 18:30 Poster Session
18:30 till late Conference Gala Dinner with live music
 

 

Day 4 - Tuesday 16 October 2012
  Session 5: Renewal vs Differentiation
Chair: Susan Strome
09:00 - 09:25

Mechanism and reconstitution in vitro of germ cell specification in mice

Mitinori Saitou, Kyoto University, Japan  

09:25 - 09:50

Chromatin dynamics and early development

Geneviève Almouzni, CNRS Institut Curie, France  

09:50 - 10:15

Determining germline fate in Arabidopsis ovules

Ueli Grossniklaus, University of Zurich, Switzerland  

10:15 - 10:30 Selected Short Talk 9

Endogenous Nodal signaling regulates germ cell potency in the developing testis

Peter Koopman, The University of Queensland, Australia
10:30 - 11:00 Morning Coffee Break
11:00 - 11:25 Development in vivo of Fertilization-Competent Oocyte-like Cells in the Absence of Meiotic Initiation or Prophase

David C. Page, Whitehead Institute, Massachusetts Institute of Technology, USA  

11:25 - 11:50 Regulation of self-renewal and differentiation In germline stem cells

Rafal Ciosk, Friedrich Miescher Institute for Biomedical Research, Switzerland

11:50 - 12:15

Genetic and Epigenetic studies of longevity: what are we learning about aging?

Brian K. Kennedy, Buck Institute, USA  

12:15 - 12:20 Symposium Ends
12:30 - 13:00 Packed Lunch
12:45 Buses Depart