Diabetes and Obesity

10:30 - 10:55

10:55 - 11:20

11:20 - 11:45

11:45 - 12:00

12:00 - 12:25

Mechanism of Action and Potential Therapeutic Role of Oxyntomodulin

12:25 -12:55

Short Talks (15 min. each)

Resat Cinar, Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, USA
Peripheral cannabinoid-1 receptor (CB1R) antagonism ameliorates insulin resistance in mice with diet-induced obesity (DIO) by reversing overactive de novo ceramide synthesis in the liver

Dennys Cintra, Federal University of São Paulo, Brazil
GPR120 mediates ER stress and anti-inflammatory response from Alfa linolenic (n3) and Oleic (n9) fatty acids in the hypothalamus of diet-induced obese rodents 

David A. Ferrick, Seahorse Bioscience; Martin Jastroch, Helmholtz Centre Munich; Werner Kammerloher, Seahorse Bioscience Germany
Measuring cellular energy metabolism: How XF technology helps to reveal metabolic dysfunctions and guides basic and translational studies

Lunch

Matthias Tschöp and Jens Brüning

Session 1A: Genetics and Metabolic Disease
Chairs: Hans-Georg Joost, German Institute of Human Nutrition, Germany; Anke Hinney, University of Duisburg-Essen, Germany

Ruth Loos, Institute of Metabolic Science, United Kingdom
The Genetic Epidemiology of Common Obesity – New Insights Through Integrating Available Data

Sadaf Farooqi, Cambridge Institute for Medical Research (CIMR), United Kingdom
Lessons from severe human obesity

Coffee break

Session 1B: Genetics and Metabolic Disease
Chairs: Giles Yeo, University of Cambridge, UK; Johannes Beckers, HelmholtzZentrum Munich, Germany

Short Talks (15 min. each)

Kenneth Dyar, Venetian Institute of Molecular Medicine, Italy
Intrinsic and extrinsic control of circadian gene expression in skeletal muscle

Ville Hietakangas, University of Helsinki, Finland
Mondo-Mlx-regulated transcriptional network is essential for dietary sugar tolerance in Drosophila

Fiona McMurray, Medical Research Council Harwell, UK
Inactivation of Fto in the adult mouse alters body composition and metabolism

Ludger Scheja, University Medical Center Hamburg-Eppendorf, Germany
Tissue-specific changes of de novo lipogenesis predict metabolic health in humans

Coffee break

Keynote Lecture I
Chair: Jens Brüning, University of Cologne, Germany

Ron Kahn, Joslin Diabetes Center, Harvard Medical School, USA
Genes and Environment in development of insulin resistance

Dinner

After-dinner Drinks and Poster Preview

Chairs: Andries Kalsbeek, Academic Medical Center (AMC), University of Amsterdam (UvA), The Netherlands; Heike Muenzberg-Gruening, Pennington Biomedical Research Center, USA

AgRP neurons control dopamine neuronal plasticity and complex behaviors not related to feeding

Leptin action outside of the ARC

Session 2B: CNS and Control of Energy Metabolism
Chairs: Christine Könner, University of Cologne, Germany; Uberto Pagotto, University of Bologna, Italy

FTO plays a role in the cellular response to amino-acid deprivation

Short Talks (15 min. each)

Marc Claret, The August Pi i Sunyer Biomedical Research Institute, Spain
Deletion of miRNA processing enzyme Dicer in POMC-expressing cells leads to neurodegeneration and development of obesity 

Serge Luquet, University of Paris-Diderot-Paris 7, France
Hypothalamic AgRP-neurons control peripheral substrate utilization and nutrient partitioning

Viola Nordström, German Cancer Research Center, Germany
Leptin signaling in hypothalamic neurons is regulated by glucosylceramide synthase (GCS)-derived gangliosides

Paul Pfluger, HelmholtzZentrum Munich, Germany
DUSP8: a rheostat for hypothalamic Jnk signaling and systemic glucose intolerance

Lunch and Poster Session I (kindly sponsored by Roche)

Chairs: Kerstin Stemmer, Helmholtz Zentrum München, Germany; Norbert Leitinger, University of Virginia,USA

Mammalian Target of Rapamycin regulates pancreatic ß-cells insulin secretion

p62 and PKCz, Partners in Cancer and Metabolism

Transcriptional pathways in metabolism and cancer

Philippe Scherer, UT Southwestern Medical School, USA
Metabolic consequences of Adipose Tissue Dysfunction

Coffee Break

Session 3B: Metabolism, Inflammasome & Cancer
Chairs: Dennis Brümmer, University of Kentucky, USA; Martin Hrabe de Angelis, HelmholtzZentrum Munich, Germany

Kei Sakamoto, Nestlé Institute of Health Sciences SA, Switzerland
Molecular mechanism by which insulin controls glycogen synthesis in muscle and liver

Juleen Zierath, Karolinska Institute, Sweden
Nature or nurture? gene/environment influence in skeletal muscle insulin sensitivity in Type 2 Diabetes patients

Short Talks (15 min each)

Aristides Lytras, Biomedical Research Foundation, Academy of Athens, Greece
Hepatocyte levels of the scaffolding subunit of protein phosphatase 2A control the sensitivity of the AMPK/mTOR sensor system and modify autophagy marker 

Sinem Karaman, Swiss Federal Institute of Technology, Switzerland
Capture of VEGFR-3 ligands shifts macrophage polarization in adipose tissue to the M2 profile and enhances insulin sensitivity in mice

Dinner

After-dinner Drinks

Chairs: Martin Klingenspor and Dirk Haller, Technical University Munich, Germany

Protein folding homeostasis & metabolic regulation

Session 4B: ER Stress & Mitochondrial Function in Metabolic Disease
Chairs: Martin Jastroch, HelmholtzZentrum Munich, Germany; Günter Müller, Sanofi Pharma, Germany

Umut Ozcan, Harvard Medical School, USA
Emerging roles of ER stress in development of obesity and Type 2 diabetes

Short Talks (15 min. each)

Marie Björnholm, Karolinska Institute, Sweden
Effects of AMPK Activation on Glucose and Energy Homeostasis in Leptin-Deficient ob/ob Mice 

Carles Canto, Nestlé Institute of Health Sciences, Switzerland
Effects of dietary supplementation with nicotinamide riboside on NAD+ homeostasis and energy metabolism

Dawid Krokowski, Case Western Reserve University, USA
Increased amino acid flux as a causative event in ER stress-induced diabetes

J. Andrew Pospisilik, Max Planck Institute of Immunobiology and Epigenetics, Germany
Rapid rewiring of adipocyte metabolism by a novel Hedgehog-Ampk axis

Lunch and Poster Session II (kindly sponsored by Roche)

Session 5: Peripheral Control of Metabolism
Chairs: Hans Hauner, Technical University Munich, Germany; Jörg Heeren, University Medical Clinic Hamburg, Germany

Randy Seeley, Cincinnati Obesity and Diabetes Centre, USA
Molecular targets of the effects of bariatric surgery

Antonio Vidal-Puig, University of Cambridge, UK
Adipose tissue expandability, lipotoxicity and the Metabolic syndrome

Bart Staels, University of Lille, France
Liver metabolism & circadian clock

Keynote Lecture II
Chair: Martin Myers, University of Michigan, USA

Markus Stoffel, Swiss Federal Institute of Technology, Switzerland
MicroRNAs: function in metabolism and therapeutic opportunities

Gala Dinner & Party (Live music: Soul Kitchen Band)

Chairs: Michael Ristow, University of Jena, Germany; Annette Schuermann, German Institute of Human Nutrition, Germany

Bernard Thorens, University of Lausanne, Switzerland
Brain-Endocrine-Pancreas Interactions in the Control of Glucose Homeostasis

Rudolf Zechner, University of Graz, Austria
Lipolysis and thermogenesis

Matthias Blueher, University of Leipzig, Germany
Adipose tissue dysfunction in obesity

Session 6B: Systems Biology of Type 2 Diabetes
Chairs: Serge Luquet, University of Paris-Diderot-Paris 7, France; Susanna Hofmann, HelmholzZentrum Munich, Germany

Lora Heisler, University of Cambridge, UK
Integration of metabolic signals by CNS Serotonin pathways

Short Talks (15 min. each)

Chun-Xia Yi, Helmholtz Zentrum München, Germany
High calorie diet triggers hypothalamic angiopathy 

Martin Gericke, University of Leipzig, Germany
Crown-like structures as primary sit of macrophage activation and proliferation

Jan-Wilhelm Kornfeld, University of Cologne, Germany
Obesity-Induced Overexpression of miR-802 Impairs Glucose Metabolism Via Posttranscriptional Silencing of Tcf2/Hnf1beta

Chong Wee Liew, Joslin Diabetes Center, USA
Insulin Signaling Modulates Proinsulin Processing by Regulating Translation Initiation in Pancreatic ß-cells

Lunch and Poster Session III (kindly sponsored by Boehringer Ingelheim)

Keynote Lecture III
Chair: Philip Larsen, Sanofi Pharma, Germany

Richard DiMarchi, Indiana University, USA
The Pursuit of Transformational Medicines

Poster Prize & Closing Remarks
Matthias Tschöp & Jens Brüning