Diabetes and Obesity

J. Brüning, M. Tschöp

EMBL Heidelberg, Germany

Thursday 13 September - Sunday 16 September 2012


Final Programme

A PDF of the final programme can be downloaded here


Day 1 - Thursday, 13 September 2012
10:00 - 13:15 Registration
Chairs: Mads Tang-Christensen, Novo Nordisk; Alessandro Pocai, Merck

10:30 - 10:55

Mads Tang-Christensen, Novo Nordisk

10:55 - 11:20

Ruth Gimeno, Eli Lilly
Diabetes Drug Discovery at Lilly:  Targeting Key Metabolic Pathways for the Treatment of Type 2 Diabetes

11:20 - 11:45

Bradford S. Hamilton, Boehringer-Ingelheim
Characterization of a humanized 11b-hydroxysteroid dehydrogenase 1 transgenic mouse

11:45 - 12:00


12:00 - 12:25

Alessandro Pocai, Merck

Mechanism of Action and Potential Therapeutic Role of Oxyntomodulin

12:25 -12:55

Short Talks (15 min. each)

Resat Cinar, Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, USA
Peripheral cannabinoid-1 receptor (CB1R) antagonism ameliorates insulin resistance in mice with diet-induced obesity (DIO) by reversing overactive de novo ceramide synthesis in the liver

Dennys Cintra, Federal University of São Paulo, Brazil
GPR120 mediates ER stress and anti-inflammatory response from Alfa linolenic (n3) and Oleic (n9) fatty acids in the hypothalamus of diet-induced obese rodents 



David A. Ferrick, Seahorse Bioscience; Martin Jastroch, Helmholtz Centre Munich; Werner Kammerloher, Seahorse Bioscience Germany
Measuring cellular energy metabolism: How XF technology helps to reveal metabolic dysfunctions and guides basic and translational studies

12:00 - 13:15


13:15 - 13:30 Opening Remarks

Matthias Tschöp and Jens Brüning

13:30 - 15:00

Session 1A: Genetics and Metabolic Disease
Chairs: Hans-Georg Joost, German Institute of Human Nutrition, Germany; Anke Hinney, University of Duisburg-Essen, Germany

13:30 - 14:00 Philippe Froguel, Imperial College London, United Kingdom
From GWAS to rare variaFrom GWAS to rare variants for Type 2 Diabetes and Obesitynts for Type 2 Diabetes and Obesity
14:00 - 14:30

Ruth Loos, Institute of Metabolic Science, United Kingdom
The Genetic Epidemiology of Common Obesity – New Insights Through Integrating Available Data

14:30 - 15:00

Sadaf Farooqi, Cambridge Institute for Medical Research (CIMR), United Kingdom
Lessons from severe human obesity

15:00 - 15:30

Coffee break

15:30 - 17:00

Session 1B: Genetics and Metabolic Disease
Chairs: Giles Yeo, University of Cambridge, UK; Johannes Beckers, HelmholtzZentrum Munich, Germany

15:30 - 16:00

Fredrik Bäckhed, Sahlgrenska Universitiy Hospital, Sweden
The gut microbiota as a novel modulator of host metabolism and obesity

16:00 - 17:00

Short Talks (15 min. each)

Kenneth Dyar, Venetian Institute of Molecular Medicine, Italy
Intrinsic and extrinsic control of circadian gene expression in skeletal muscle

Ville Hietakangas, University of Helsinki, Finland
Mondo-Mlx-regulated transcriptional network is essential for dietary sugar tolerance in Drosophila

Fiona McMurray, Medical Research Council Harwell, UK
Inactivation of Fto in the adult mouse alters body composition and metabolism

Ludger Scheja, University Medical Center Hamburg-Eppendorf, Germany
Tissue-specific changes of de novo lipogenesis predict metabolic health in humans

17:00 - 17:30

Coffee break

17:30 - 18:30

Keynote Lecture I
Chair: Jens Brüning, University of Cologne, Germany

Ron Kahn, Joslin Diabetes Center, Harvard Medical School, USA
Genes and Environment in development of insulin resistance

18:30 - 20:00


20:00 - 23:00

After-dinner Drinks and Poster Preview



Day 2 - Friday, 14 September 2012

09:00 - 10:30

Session 2A: CNS and Control of Energy Metabolism

Chairs: Andries Kalsbeek, Academic Medical Center (AMC), University of Amsterdam (UvA), The Netherlands; Heike Muenzberg-Gruening, Pennington Biomedical Research Center, USA

09:00 - 09:30 Tamas Horvath, Yale School of Medicine, USA

AgRP neurons control dopamine neuronal plasticity and complex behaviors not related to feeding

09:30 - 10:00 Martin Myers, University of Michigan, USA

Leptin action outside of the ARC

10:00 - 10:30 Mathias Treier, Max Delbrück Center for Molecular Medicine, Germany
A hypothalamic network connecting feeding behavior and cognitive function
10:30 - 11:00 Coffee Break
11:00- 12:30

Session 2B: CNS and Control of Energy Metabolism
Chairs: Christine Könner, University of Cologne, Germany; Uberto Pagotto, University of Bologna, Italy

11:00 - 11:30 Giles Yeo, University of Cambridge, UK

FTO plays a role in the cellular response to amino-acid deprivation

11:30 - 12:30

Short Talks (15 min. each)

Marc Claret, The August Pi i Sunyer Biomedical Research Institute, Spain
Deletion of miRNA processing enzyme Dicer in POMC-expressing cells leads to neurodegeneration and development of obesity 

Serge Luquet, University of Paris-Diderot-Paris 7, France
Hypothalamic AgRP-neurons control peripheral substrate utilization and nutrient partitioning

Viola Nordström, German Cancer Research Center, Germany
Leptin signaling in hypothalamic neurons is regulated by glucosylceramide synthase (GCS)-derived gangliosides

Paul Pfluger, HelmholtzZentrum Munich, Germany
DUSP8: a rheostat for hypothalamic Jnk signaling and systemic glucose intolerance

12:30 - 14:30

Lunch and Poster Session I (kindly sponsored by Roche)

14:30 - 16:30 Session 3A: Metabolism, Inflammasome & Cancer

Chairs: Kerstin Stemmer, Helmholtz Zentrum München, Germany; Norbert Leitinger, University of Virginia,USA

14:30 - 15:00 Sara Kozma, University of Cincinnati Medical Center, USA

Mammalian Target of Rapamycin regulates pancreatic ß-cells insulin secretion

15:00 - 15:30 Jorge Moscat, Sanford Burnham Medical Research Center, USA

p62 and PKCz, Partners in Cancer and Metabolism

15:30 - 16:00 Stephan Herzig, German Cancer Reserch Center, Germany

Transcriptional pathways in metabolism and cancer

16:00 - 16:30

Philippe Scherer, UT Southwestern Medical School, USA
Metabolic consequences of Adipose Tissue Dysfunction

16:30 - 17:00

Coffee Break

17:00 - 19:00

Session 3B: Metabolism, Inflammasome & Cancer
Chairs: Dennis Brümmer, University of Kentucky, USA; Martin Hrabe de Angelis, HelmholtzZentrum Munich, Germany

17:00 - 17:30

Kei Sakamoto, Nestlé Institute of Health Sciences SA, Switzerland
Molecular mechanism by which insulin controls glycogen synthesis in muscle and liver

17:30 - 18:00

Juleen Zierath, Karolinska Institute, Sweden
Nature or nurture? gene/environment influence in skeletal muscle insulin sensitivity in Type 2 Diabetes patients

18:00 - 18:30 Gilles Mithieux, Inserm, France
Brain, liver, intestine: a triumvirate regulating glucose and energy homeostasis
18:30 - 19:00

Short Talks (15 min each)

Aristides Lytras, Biomedical Research Foundation, Academy of Athens, Greece
Hepatocyte levels of the scaffolding subunit of protein phosphatase 2A control the sensitivity of the AMPK/mTOR sensor system and modify autophagy marker 

Sinem Karaman, Swiss Federal Institute of Technology, Switzerland
Capture of VEGFR-3 ligands shifts macrophage polarization in adipose tissue to the M2 profile and enhances insulin sensitivity in mice

19:00 - 21:00


21:00 - 23:00

After-dinner Drinks



Day 3 - Saturday, 15 September 2012
09:30 - 10:30 Session 4A: ER Stress & Mitochondrial Function in Metabolic Disease

Chairs: Martin Klingenspor and Dirk Haller, Technical University Munich, Germany

09:30 - 10:00 Gokhan Hotamisligil, Harvard School of Public Health, USA
Endoplasmic Reticulum stress and dysfunction in obesity and diabetes
10:00 - 10:30 David Ron, University of Cambridge, United Kingdom

Protein folding homeostasis & metabolic regulation

10:30 - 11:00 Coffee Break
11:00 - 12:30

Session 4B: ER Stress & Mitochondrial Function in Metabolic Disease
Chairs: Martin Jastroch, HelmholtzZentrum Munich, Germany; Günter Müller, Sanofi Pharma, Germany

11:00 - 11:30

Umut Ozcan, Harvard Medical School, USA
Emerging roles of ER stress in development of obesity and Type 2 d

11:30 -12:30

Short Talks (15 min. each)

Marie Björnholm, Karolinska Institute, Sweden
Effects of AMPK Activation on Glucose and Energy Homeostasis in Leptin-Deficient ob/ob Mice 

Carles Canto, Nestlé Institute of Health Sciences, Switzerland
Effects of dietary supplementation with nicotinamide riboside on NAD+ homeostasis and energy metabolism

Dawid Krokowski, Case Western Reserve University, USA
Increased amino acid flux as a causative event in ER stress-induced diabetes

J. Andrew Pospisilik, Max Planck Institute of Immunobiology and Epigenetics, Germany
Rapid rewiring of adipocyte metabolism by a novel Hedgehog-Ampk axis

12:30 - 14:30

Lunch and Poster Session II (kindly sponsored by Roche)

14:30 - 16:00

Session 5: Peripheral Control of Metabolism
Chairs: Hans Hauner, Technical University Munich, Germany; Jörg Heeren, University Medical Clinic Hamburg, Germany

14:30 - 15:00

Randy Seeley, Cincinnati Obesity and Diabetes Centre, USA
Molecular targets of the effects of bariatric surgery

15:00 - 15:30

Antonio Vidal-Puig, University of Cambridge, UK
Adipose tissue expandability, lipotoxicity and the Metabolic syndrome

15:30 - 16:00

Bart Staels, University of Lille, France
Liver metabolism & circadian clock

16:00 - 16:30 Coffee Break

16:30 - 17:30

Keynote Lecture II
Chair: Martin Myers, University of Michigan, USA

Markus Stoffel, Swiss Federal Institute of Technology, Switzerland
MicroRNAs: function in metabolism and therapeutic opportunities

18:30 - 24:00

Gala Dinner & Party (Live music: Soul Kitchen Band)



Day 4 - Sunday, 16 September 2012
09:00 - 10:30 Session 6A: Systems Biology of Type 2 Diabetes

Chairs: Michael Ristow, University of Jena, Germany; Annette Schuermann, German Institute of Human Nutrition, Germany

09:00 - 09:30

Bernard Thorens, University of Lausanne, Switzerland
Brain-Endocrine-Pancreas Interactions in the Control of Glucose

09:30 - 10:00

Rudolf Zechner, University of Graz, Austria
Lipolysis and thermogenesis

10:00 - 10:30

Matthias Blueher, University of Leipzig, Germany
Adipose tissue dysfunction in obesity

10:30 - 11:00 Coffee Break

11:00 - 12:30

Session 6B: Systems Biology of Type 2 Diabetes
Chairs: Serge Luquet, University of Paris-Diderot-Paris 7, France; Susanna Hofmann, HelmholzZentrum Munich, Germany

11:00 - 11:30

Lora Heisler, University of Cambridge, UK
Integration of metabolic signals by CNS Serotonin pathways

11:30 - 12:30

Short Talks (15 min. each)

Chun-Xia Yi, Helmholtz Zentrum München, Germany
High calorie diet triggers hypothalamic angiopathy 

Martin Gericke, University of Leipzig, Germany
Crown-like structures as primary sit of macrophage activation and proliferation

Jan-Wilhelm Kornfeld, University of Cologne, Germany
Obesity-Induced Overexpression of miR-802 Impairs Glucose Metabolism Via Posttranscriptional Silencing of Tcf2/Hnf1beta

Chong Wee Liew, Joslin Diabetes Center, USA
Insulin Signaling Modulates Proinsulin Processing by Regulating Translation Initiation in Pancreatic ß-cells

12:30 - 14:30

Lunch and Poster Session III (kindly sponsored by Boehringer Ingelheim)

14:30 - 15:30

Keynote Lecture III
Chair: Philip Larsen, Sanofi Pharma, Germany

Richard DiMarchi, Indiana University, USA
The Pursuit of Transformational Medicines

15:30 - 15:45

Poster Prize & Closing Remarks
Matthias Tschöp & Jens