Cardiac Biology - From Development to Regenerative Medicine

N. Rosenthal, B. Graham, S. Dimmeler, D. Stainier

EMBL Heidelberg, Germany

Friday 7 June - Monday 10 June 2013

context.title

Final Programme

Day 1 - Friday, 7 June 2013
Time Speaker Title
11:30–13:15 Registration and Lunch  
13:15–13-30 Matthias Hentze, EMBL Heidelberg, Germany Opening remarks

Session 1: Heart development 
13:30–17:30

Chair: Nadia Rosenthal, EMBL Australia, Australia

13:30–14:00 Margaret Buckingham, Institut Pasteur, France

A regulatory switch that operates in progenitor cells in the second heart field and myocardial cells in the heart

14:00–14:30

Richard Harvey, Victor Chang Cardiac Research Institute, Australia

Cardiac transcription factor networks - targeting the kernel

14:30–14:45 Manfred Gessler, University of Wuerzburg, Germany Hey bHLH target genes in cardiovascular development
14:45–15:00 Diego Franco, University of Jaen, Spain Regulation of atrioventricular epithelial-to-mesenchymal transition by microRNAs
15:00 –15:30 Coffee Break
15:30–16:00 Cecilia Lo, University of Pittsburgh School of Medicine, USA Essential role of the cilia and left-right patterning in congenital heart disease
16:00–16:30 William Pu, Boston Children’s Hospital, USA YAP1 activation enhances myocardial outcome in adult heart injury
16:30–16:45 Salim Seyfried, Max Delbrück Center, Germany Unilateral dampening of Bmp activity by Nodal generates cardiac left-right asymmetry
16:45–17:00 Mirana Ramialison, Victor Chang Cardiac Research Institute, Australia Co-option of ubiquitous transcription factors in the cardiac developmental gene regulatory network
17:00–17:30 Coffee break  
17:30–18:30

Keynote lecture

Eric Olson, UT Southwestern Medical Center, USA 
The Molecules and Mechanisms of Heart Development, Disease and Regeneration
18:30–20:00 Dinner in the EMBL Canteen
20:00–23:00

After dinner drinks in the ATC Rooftop Lounge and poster sneak preview.

 

 

Day 2 - Saturday, 8 June 2013
Time Speaker Title
08:30 Morning coffee  

Session 2: Genetics and Epigenetic Controls
09:00–12:30 

Chair: Eric Olson, UT Southwestern Medical Center, USA

09:00–09:30 Vincent Christoffels, University of Amsterdam, The Netherlands

Evolutionary conserved transcriptional networks for electrical patterning of the heart

09:30–10:00 Didier Stainier, Max-Planck-Institut for Heart and Lung Research, Germany

Chamber specialization and cell behavior during zebrafish heart maturation

10:00–10:15 Bernhard Herrmann, Max Planck Institute for Molecular Genetics, Germany The tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse
10:15–10:30 Martyna Adamowicz-Brice, Imperial College London Complete cardiac regeneration in a mouse model of myocardial infarction
10:30–11:00 Coffee Break
11:00–11:30 Silke Sperling, Charité Medical Faculty and Max Delbrück Center for Molecular Medicine, Germany Crosstalk between chromatin remodeling, transcription factors and histone modifications
11:30–12:00 Stefanie Dimmeler, Goethe-University Frankfurt am Main, Germany Epigenetic control of cardiac function
12:00–12:15 Enrique Lara-Pezzi, CNIC, Spain The calcineurin splicing variant improves cardiac remodelling post-infarction and reduces cardiac hypertrophy after transaortic banding
12:15–12:30 Yonggang Zhou, MPI for Heart and Lung Research, Germany Molecular circuits controlled by Sirt1 during heart development
12:30–13:30 Lunch
13:30–14:30 Poster Session 1 Helix A

Session 3: Progenitors in the Developing Heart
14:30–18:00

Chair: Didier Stainier, Max-Planck-Institut for Heart and Lung Research, Germany

14:30–15:00 Michael Schneider, Imperial College London, UK Unmasking Phenotypic Micro-heterogeneities in Adult Cardiac Progenitor Cells: Clonal Analysis, Fate Mapping, and Single Cell QRT-PCR
15:00–15:30 Bernhard Kuhn, Boston Children's Hospital, USA Cardiomyocyte cell cycling and myocardial growth and regeneration in mice and humans
15:30–15:45 Nadia Mercader, CNIC, Spain Heartbeat driven pericardiac fluid forces direct epicardium morphogenesis
15:45–16:00 Naoki Mochizuki, National Cerebral and Cardiovascular Center, Japan Endodermal S1P-Yap signaling regulates cardiogenesis by controlling cardiac precursor cell migration
16:00–16:30 Coffee Break
16:30–17:00 Paul Riley, University of Oxford, United Kingdom

Epicardium-derived DIY Cardiac Repair

 
17:00–17:30 Jon Epstein, Perelman School of Medicine at the University of Pennsylvania, USA Regulation of cardiac progenitor cell expansion
17:30–18:30

Keynote lecture

John Stamatoyannopoulos, University of Washington School of Medicine, Seattle, USA

Negotiating the epigenetic landscape:  Encoding developmental fate and cellular maturity

 

 
18:30–20:00 Dinner in the EMBL Canteen
20:00–23:00 After dinner drinks in the ATC Rooftop Lounge  
Day 3 - Sunday, 9 June 2013
Time Speaker Title
08:30 Morning coffee  

Session 4: Cardiovascular Stem Cell Differentiation
09:00–12:30

Chair: Bob Graham, Victor Chang Cardiac Research Institute, Australia

09:00–09:30 Steve Hauschka, University of Washington, USA   

Design and Functional Analysis of High-Level Tissue-Specific Regulatory Cassettes for Gene- & Cell-Mediated Cardiac Therapy

09:30–09:45 Andrea Munsterberg, University of East Anglia, UK Smad1 integrates BMP2 and Wnt3a signals during cardiac progenitor cell migration
09:45–10:00 David Zebrowski, University of Erlangen-Nürnberg, Germany Alterations in Ciliogenesis and Centrosome Integrity During Cardiomyocyte Terminal Differentiation
10:00–10:30 Ken Chien, Harvard Stem Cell Institute, USA Driving in vivo heart progenitor cell fate and cardiac repair via modified mRNA
10:30–11:00 Coffee Break
11:00–11:30 Joseph Wu, Stanford University School of Medicine, USA iPSCs for cardiac disease modeling and drug screening
11:30–12:00 Lior Gepstein, Technion-Israel Institute of Technology, Israel Induced Pluripotent Stem Cells: Implications for Basic and Translational Cardiovascular Research
12:00–12:15 Malin Jonsson Boezelman, Genome Institute of Singapore Human stem cell-derived cardiomyocytes lack sensitivity to drug induced arrhythmias beyond hERG
12:15–12:30 Francesca Rochais, IBDM CNRS UMR-7288, France Cell-autonomous Fgf10 signaling regulates cardiomyocyte proliferation in the right ventricle of the fetal mouse heart
12:30–13:30 Lunch
13:30–14:45 Poster Session 2 Helix A

Session 5: Regenerative Biology 
14:45–18:30

Chair: Stefanie Dimmeler, Goethe-University Frankfurt am Main, Germany

14:45–15:15 Thomas Braun, Max-Planck-Institut for Heart and Lung Research, Germany Molecular circuits controlling myocardial remodeling and regeneration
15:15–15:45 Ahsan Husain, Emory University, USA  Maturational growth of the preadolescent heart: implications for the timing of cardiomyocyte terminal differentiation
15:45–16:00 Olaf Bergmann, Karolinska Institutet, Sweden Cardiomyocyte Renewal in Growing and Adult Human Hearts
16:00–16:30 Coffee Break  
16:30–17:00 Nadia Rosenthal, EMBL Australia, Australia

Immune regulation of regeneration

17:00–17:30 Bernd Fleischmann, University of Bonn, Germany Stem Cell-based modulation of Heart Function
17:30–18:30

Keynote lecture

Samuel Stupp, Northwestern University, USA
Regenerative Nanomedicine for the Cardiovascular System
18:30–00:00 Conference Dinner and party EMBL Canteen and ATC Foyer for the party
Day 4 - Monday, 10 June 2013
Time Speaker Title
08:30 Morning Coffee  

Session 6: Translation 
09:00 –13:15

Chair: Thomas Braun, Max-Planck-Institut for Heart and Lung Research, Germany

09:00–09:30 Bernardo Nadal-Ginard, Liverpool John Moores University, United Kingdom

Adult c-kitpos Cardiac Stem Cells Are Necessary and Sufficient for Functional Cardiac Regeneration and Repair

09:30–10:00 Paul J. Simmons, Mesoblast, Australia Mesenchymal Precursor Cells (MPC) as a cellular therapy for the damaged heart
10:00–10:15 Felix Engel, Universitätsklinikum Erlangen, Germany Small molecule screen identifies carbacyclin as an inducer of mammalian cardiomyocyte proliferation
10:15–10:30 Gabriele D'Uva, Weizmann Institute of Science, Israel Heart regeneration and tumorigenicity: oncogenic ErbB2 as a driving force
10:30–10:45 Foteini Mourkioti, Stanford University, USA Role of Telomere Dysfunction in Duchenne Muscular Dystrophy
10:45–11:15 Coffee Break
11:15–12:15       Poster session 3  
12:15–12:45        Chuck Murry, University of Washington, USA Cardiogenesis with Pluripotent Human Stem Cells
12:45–13:15       

Andreas Zeiher, J.W. Goethe University Hospital, Germany

Cell therapy of post-infarction heart failure: determinants of clinical efficacy

13:15–13:45               Closing remarks  
14:15                 Packed lunch and departure