Cardiac Biology - From Development to Regenerative Medicine

N. Rosenthal, B. Graham, S. Dimmeler, D. Stainier

EMBL Heidelberg, Germany

Friday 7 June - Monday 10 June 2013


Final Programme

Day 1 - Friday, 7 June 2013
Time Speaker Title
11:30–13:15 Registration and Lunch  
13:15–13-30 Matthias Hentze, EMBL Heidelberg, Germany Opening remarks

Session 1: Heart development 

Chair: Nadia Rosenthal, EMBL Australia, Australia

13:30–14:00 Margaret Buckingham, Institut Pasteur, France

A regulatory switch that operates in progenitor cells in the second heart field and myocardial cells in the heart


Richard Harvey, Victor Chang Cardiac Research Institute, Australia

Cardiac transcription factor networks - targeting the kernel

14:30–14:45 Manfred Gessler, University of Wuerzburg, Germany Hey bHLH target genes in cardiovascular development
14:45–15:00 Diego Franco, University of Jaen, Spain Regulation of atrioventricular epithelial-to-mesenchymal transition by microRNAs
15:00 –15:30 Coffee Break
15:30–16:00 Cecilia Lo, University of Pittsburgh School of Medicine, USA Essential role of the cilia and left-right patterning in congenital heart disease
16:00–16:30 William Pu, Boston Children’s Hospital, USA YAP1 activation enhances myocardial outcome in adult heart injury
16:30–16:45 Salim Seyfried, Max Delbrück Center, Germany Unilateral dampening of Bmp activity by Nodal generates cardiac left-right asymmetry
16:45–17:00 Mirana Ramialison, Victor Chang Cardiac Research Institute, Australia Co-option of ubiquitous transcription factors in the cardiac developmental gene regulatory network
17:00–17:30 Coffee break  

Keynote lecture

Eric Olson, UT Southwestern Medical Center, USA 
The Molecules and Mechanisms of Heart Development, Disease and Regeneration
18:30–20:00 Dinner in the EMBL Canteen

After dinner drinks in the ATC Rooftop Lounge and poster sneak preview.



Day 2 - Saturday, 8 June 2013
Time Speaker Title
08:30 Morning coffee  

Session 2: Genetics and Epigenetic Controls

Chair: Eric Olson, UT Southwestern Medical Center, USA

09:00–09:30 Vincent Christoffels, University of Amsterdam, The Netherlands

Evolutionary conserved transcriptional networks for electrical patterning of the heart

09:30–10:00 Didier Stainier, Max-Planck-Institut for Heart and Lung Research, Germany

Chamber specialization and cell behavior during zebrafish heart maturation

10:00–10:15 Bernhard Herrmann, Max Planck Institute for Molecular Genetics, Germany The tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse
10:15–10:30 Martyna Adamowicz-Brice, Imperial College London Complete cardiac regeneration in a mouse model of myocardial infarction
10:30–11:00 Coffee Break
11:00–11:30 Silke Sperling, Charité Medical Faculty and Max Delbrück Center for Molecular Medicine, Germany Crosstalk between chromatin remodeling, transcription factors and histone modifications
11:30–12:00 Stefanie Dimmeler, Goethe-University Frankfurt am Main, Germany Epigenetic control of cardiac function
12:00–12:15 Enrique Lara-Pezzi, CNIC, Spain The calcineurin splicing variant improves cardiac remodelling post-infarction and reduces cardiac hypertrophy after transaortic banding
12:15–12:30 Yonggang Zhou, MPI for Heart and Lung Research, Germany Molecular circuits controlled by Sirt1 during heart development
12:30–13:30 Lunch
13:30–14:30 Poster Session 1 Helix A

Session 3: Progenitors in the Developing Heart

Chair: Didier Stainier, Max-Planck-Institut for Heart and Lung Research, Germany

14:30–15:00 Michael Schneider, Imperial College London, UK Unmasking Phenotypic Micro-heterogeneities in Adult Cardiac Progenitor Cells: Clonal Analysis, Fate Mapping, and Single Cell QRT-PCR
15:00–15:30 Bernhard Kuhn, Boston Children's Hospital, USA Cardiomyocyte cell cycling and myocardial growth and regeneration in mice and humans
15:30–15:45 Nadia Mercader, CNIC, Spain Heartbeat driven pericardiac fluid forces direct epicardium morphogenesis
15:45–16:00 Naoki Mochizuki, National Cerebral and Cardiovascular Center, Japan Endodermal S1P-Yap signaling regulates cardiogenesis by controlling cardiac precursor cell migration
16:00–16:30 Coffee Break
16:30–17:00 Paul Riley, University of Oxford, United Kingdom

Epicardium-derived DIY Cardiac Repair

17:00–17:30 Jon Epstein, Perelman School of Medicine at the University of Pennsylvania, USA Regulation of cardiac progenitor cell expansion

Keynote lecture

John Stamatoyannopoulos, University of Washington School of Medicine, Seattle, USA

Negotiating the epigenetic landscape:  Encoding developmental fate and cellular maturity


18:30–20:00 Dinner in the EMBL Canteen
20:00–23:00 After dinner drinks in the ATC Rooftop Lounge  
Day 3 - Sunday, 9 June 2013
Time Speaker Title
08:30 Morning coffee  

Session 4: Cardiovascular Stem Cell Differentiation

Chair: Bob Graham, Victor Chang Cardiac Research Institute, Australia

09:00–09:30 Steve Hauschka, University of Washington, USA   

Design and Functional Analysis of High-Level Tissue-Specific Regulatory Cassettes for Gene- & Cell-Mediated Cardiac Therapy

09:30–09:45 Andrea Munsterberg, University of East Anglia, UK Smad1 integrates BMP2 and Wnt3a signals during cardiac progenitor cell migration
09:45–10:00 David Zebrowski, University of Erlangen-Nürnberg, Germany Alterations in Ciliogenesis and Centrosome Integrity During Cardiomyocyte Terminal Differentiation
10:00–10:30 Ken Chien, Harvard Stem Cell Institute, USA Driving in vivo heart progenitor cell fate and cardiac repair via modified mRNA
10:30–11:00 Coffee Break
11:00–11:30 Joseph Wu, Stanford University School of Medicine, USA iPSCs for cardiac disease modeling and drug screening
11:30–12:00 Lior Gepstein, Technion-Israel Institute of Technology, Israel Induced Pluripotent Stem Cells: Implications for Basic and Translational Cardiovascular Research
12:00–12:15 Malin Jonsson Boezelman, Genome Institute of Singapore Human stem cell-derived cardiomyocytes lack sensitivity to drug induced arrhythmias beyond hERG
12:15–12:30 Francesca Rochais, IBDM CNRS UMR-7288, France Cell-autonomous Fgf10 signaling regulates cardiomyocyte proliferation in the right ventricle of the fetal mouse heart
12:30–13:30 Lunch
13:30–14:45 Poster Session 2 Helix A

Session 5: Regenerative Biology 

Chair: Stefanie Dimmeler, Goethe-University Frankfurt am Main, Germany

14:45–15:15 Thomas Braun, Max-Planck-Institut for Heart and Lung Research, Germany Molecular circuits controlling myocardial remodeling and regeneration
15:15–15:45 Ahsan Husain, Emory University, USA  Maturational growth of the preadolescent heart: implications for the timing of cardiomyocyte terminal differentiation
15:45–16:00 Olaf Bergmann, Karolinska Institutet, Sweden Cardiomyocyte Renewal in Growing and Adult Human Hearts
16:00–16:30 Coffee Break  
16:30–17:00 Nadia Rosenthal, EMBL Australia, Australia

Immune regulation of regeneration

17:00–17:30 Bernd Fleischmann, University of Bonn, Germany Stem Cell-based modulation of Heart Function

Keynote lecture

Samuel Stupp, Northwestern University, USA
Regenerative Nanomedicine for the Cardiovascular System
18:30–00:00 Conference Dinner and party EMBL Canteen and ATC Foyer for the party
Day 4 - Monday, 10 June 2013
Time Speaker Title
08:30 Morning Coffee  

Session 6: Translation 
09:00 –13:15

Chair: Thomas Braun, Max-Planck-Institut for Heart and Lung Research, Germany

09:00–09:30 Bernardo Nadal-Ginard, Liverpool John Moores University, United Kingdom

Adult c-kitpos Cardiac Stem Cells Are Necessary and Sufficient for Functional Cardiac Regeneration and Repair

09:30–10:00 Paul J. Simmons, Mesoblast, Australia Mesenchymal Precursor Cells (MPC) as a cellular therapy for the damaged heart
10:00–10:15 Felix Engel, Universitätsklinikum Erlangen, Germany Small molecule screen identifies carbacyclin as an inducer of mammalian cardiomyocyte proliferation
10:15–10:30 Gabriele D'Uva, Weizmann Institute of Science, Israel Heart regeneration and tumorigenicity: oncogenic ErbB2 as a driving force
10:30–10:45 Foteini Mourkioti, Stanford University, USA Role of Telomere Dysfunction in Duchenne Muscular Dystrophy
10:45–11:15 Coffee Break
11:15–12:15       Poster session 3  
12:15–12:45        Chuck Murry, University of Washington, USA Cardiogenesis with Pluripotent Human Stem Cells

Andreas Zeiher, J.W. Goethe University Hospital, Germany

Cell therapy of post-infarction heart failure: determinants of clinical efficacy

13:15–13:45               Closing remarks  
14:15                 Packed lunch and departure