The Non-Coding Genome

E. Izaurralde, D. Bartel, J. Vogel, J. Rinn

EMBL Heidelberg, Germany

Wednesday 9 October - Saturday 12 October 2013


Final Programme

A PDF version of the programme is availble here

Day 1 - Wednesday 9 October 2013

Arrival and Registration

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Efficient silencing of non-coding RNA with LNA™ Gapmers and inhibitors

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16:45-17:00 Welcome Remarks  
Session 1: The diversity of non-coding RNAs
Chair: Elisa Izaurralde
17:00-17:30 Gisela Storz, National Institutes of Health, USA Central roles of bacterial RNAs in regulating metabolism
17:30-18:00 Nikolaus Rajewsky, The Max Delbrück Center for Molecular Medicine, Germany RNA: Protein Interactions
18:00-18:15 Thomas Hansen, Aarhus University, Denmark Natural RNA circles function as efficient miRNA sponges
18:15-18:45 COFFEE BREAK ATC Foyer
18:45-19:15  John Mattick, Garvan Institute of Medical Research, Australia The human genome as the zip file extraordinaire
19:15-19:45 David C. Baulcombe, University of Cambridge, United Kingdom RNA silencing and epigenetics in tomato and Chlamydomonas
19:45-20:00 Ana Marques, University of Oxford, United Kingdom Cross talking noncoding RNAs confer central nervous system specificity to Spinocerebellar Ataxia 7 pathology
20:00-20:15 Reini Luco, IGH CNRS, France A long non coding RNA regulates chromatin mediated modulation of alternative splicing
20:15-23:00 DINNER
EMBL Canteen
Day 2 - Thursday 10 October 2013
Session 2: miRNAs function and mechanisms
Chair: David P. Bartel
09:00 - 09:30 Jeannie T. Lee, Howard Hughes Medical Institute and Harvard Medical School, USA The roles of long noncoding RNA in epigenetic regulation
09:30-10:00 V. Narry Kim, Seoul National University, Korea 3’ End Modifications in the MicroRNA Pathway
10:00-10:15 Eran Hornstein, Weizmann Institute of Science, Israel Dicer activity and microRNA maturation are regulated by stress signaling in neurodegeneration
10:15-10:45 COFFEE BREAK ATC Foyer
10:45-11:15 Witold Filipowicz, Friedrich Miescher Institute for Biomedical Research, Switzerland Mechanisms and Regulation of miRNA mediated Repression in Mammalian Cells
11:15-11:45 Antonio J. Giraldez, Yale University, USA Using ribosome footprinting to characterize the coding potential on the genome
11:45-12:00 Remy Denzler, ETH Zürich, Switzerland Quantitative evaluation of the relationship of miRNA and target abundance in liver: Implications for disease
12:00-12:15 Josephine Malmevik, Lund University, Sweden Specific inhibition of miR 124 function improves spatial and working memory capacity in mice
12:15-12:30 Ana Eulalio, Institute for Molecular Infection Biology, University of Würzburg, Germany Functional high throughput screening identifies microRNAs regulating Salmonella infection
12:30-14:00 LUNCH ATC Foyer
Session 3: Non-coding RNAs in prokaryotes
Chair: Gisela Storz
14:00-14:30 John Van der Oost, Wageningen University, The Netherlands DNA guided DNA interference by prokaryotic Argonaute
14:30-15:00 Jennifer A. Doudna, University of California, Berkeley and Howard Hughes Medical Institute, USA RNA-programmed genome defense and genomic engineering
15:00-15:30 Alexei Aravin, California Institute of Technology, USA Small RNA: from bacteria to metazoan germline
15:30-16:00 COFFEE BREAK ATC Foyer
16:00-16:30 Gerhart Wagner, Uppsala University, Sweden Bacterial sRNAs regulating transcription factors: mechanistic aspects and regulatory properties
16:30-17:00 Jörg Vogel, University of Würzburg, Germany The RNA complement of pathogen and host revealed by Dual RNA-seq
17:00-17:15 Yvonne Göpel, University of Göttingen, Germany Targeted decay of small RNA GlmZ by RNase E adaptor protein RapZ and inhibition by sRNA mimicry GlmY
17:15-20:00 POSTER SESSION I - EVEN numbers ATC Helices A and B
20:00-23:00 DINNER EMBL Canteen
Day 3 - Friday 11 October 2013
Session 4: piRNAs and siRNAs: Biogenesis and function
Chair: V. Narry Kim
09:00-09:30 Mikiko C. Siomi, University of Tokyo, Japan Production and functions of PIWI interacting RNAs in Drosophila
09:30-09:45 Peter Sarkies, University of Cambridge, United Kingdom
Social RNA: Interspecies small RNA mediated communication in nematodes
09:45-10:00 Nicole Darricarrère, Yale University, USA A Small RNA triggered nuclear activity by targeting a large chromosomal region in Human cells
10:00-10:15 Nahid Shamandi, IJPB, France Plants encode a general siRNA suppressor that is induced and suppressed by viruses
10:15-10:45 COFFEE BREAK ATC Foyer
10:45-11:15 Julius Brennecke, Institute of Molecular Biotechnology, Austria The involvement of chromatin in the Drosophila piRNA pathway
11:15-11:30 Eva Maria Weick, The Wellcome Trust/CRUK Gurdon Instititute, United Kingdom PRDE 1, a novel piRNA biogenesis factor, reveals separate functions for two classes of piRNAs in C. elegans
11:30-11:45 Sho Goh, Cold Spring Harbor Laboratory, USA Identification of C. elegans piRNA biogenesis factors through a genome wide RNAi screen
11:45-12:00 Maike Laussmann, EMBL, Germany Imaging the dynamic nature of the piRNA pathway in living cells
12:00-12:15 Markus Hafner, The Rockefeller University, USA Transcriptome wide identification and characterization of coding and non coding targets of human DND1
12:15-14:00 LUNCH ATC Foyer
Session 5: Transcriptional gene silencing
Chair: John L. Rinn
14:00-14:30 Irene Bozzoni, University of Rome, Italy Biogenesis and function of linc MD1 in muscle differentiation
14:30-15:00 Shiv Grewal, National Institutes of Health, National Cancer Institute, USA Heterochromatin formation by RNAi and RNAi-independent RNA processing factors
15:00-15:15 Leila Todeschini, Université Joseph Fourier, Institut Albert Bonniot, France Identification of a new RNA based epigenetic mechanism involved in heterochromatic gene silencing and sexual differentiation control in fission yeast
15:15-15:45 COFFEE BREAK ATC Foyer
15:45-16:15 Marc Bühler, Friedrich Miescher Institute for Biomedical Research, Switzerland Non coding RNA activity in the fission yeast nucleus
16:15-16:45 Edith Heard, Institut Curie, France X chromosome inactivation : a paradigm of epigenetic regulation via non coding RNA
16:45-17:00 Roberto Bonasio, HHMI / NYU School of Medicine, USA
Interactions between JARID2 and noncoding RNAs regulate PRC2 recruitment to chromatin
17:00-17:15 Maite Huarte, CIMA, University of Navarra, Spain The lincRNA PINT connects the p53 pathway with epigenetic silencing by PRC2
17:15-20:00 POSTER SESSION II– ODD numbers ATC Helices A and B
20:00-21:30 GALA DINNER EMBL Canteen
21:30-00:30 PARTY ATC Foyer
Day 4 - Saturday 12 October 2013
Session 6: Structure and more mechanisms
Chair: Jennifer A. Doudna
09:00-09:30 Dinshaw J. Patel, Memorial Sloan-Kettering Cancer Center, USA Structure Function Studies of Cytosolic DNA Sensors Governing the Interferon Response
09:30-10:00 Elisa Izaurralde, Max Planck Institute for Developmental Biology, Germany Structural insight into the interaction of GW182 proteins with deadenylase complexes
10:00-10:15 Roberto Perales, Cold Spring Harbor Laboratory, USA lin 42 functions as a capacitor of microRNA expression
10:15-10:45 COFFEE BREAK ATC Foyer
10:45-11:15 David P. Bartel, HHMI/MIT/Whitehead Institute, USA  MicroRNAs and their regulatory effects
11:15-11:45 Olivier Voinnet, Swiss Federal Institute of Technology Zurich, Switzerland Antiviral RNAi in mammals
11:45-12:00 Keith Vance, University of Oxford, United Kingdom The long non coding RNA Paupar regulates the expression of both local and distal neuronal genes
12:00-12:15 Liz Bayne, University of Edinburgh, United Kingdom Structural analysis of Stc1: insights into the coupling of RNAi and chromatin modification
12:15-14:00 LUNCH EMBL Canteen
Session 7: Long Non-coding RNAs
Chair: Jörg Vogel
14:00-14:30 Howard Y. Chang, Stanford University, USA Genome Regulation by Long Noncoding RNAs
14:30-15:00 Ingrid Grummt, German Cancer Research Center, Germany Noncoding RNA targets chromatin modifying enzmes to regulatory gene sequences
15:00-15:15 Igor Ulitsky, Weizmann Institute of Science, Israel Common and distinct features of short translated ORFs in lincRNAs and 5'UTRs
15:15-15:45 COFFEE BREAK ATC Foyer
15:45-16:15 Ling-Ling Chen, Institute of Biochemistry and Cell Biology, China Functional intronic long noncoding RNAs
16:15-16:45 John L. Rinn, Harvard University, USA Multiple Knockout Mouse Models Reveal lincRNAs are Required for Life and Brain Development
16:45-17:00 Maxime Wery, Institut Curie, France The cryptic lncRNA XUTs coexist with RNAi in yeast species
17:00-17:15 Concluding Remarks ATC Auditorium