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The general aim of the symposium is to explore the possible synergisms and cross-talk between the large-scale and classical approaches to biological networks.
Understanding the molecular mechanisms of biological function largely relies on the systematic charting of the dynamics interactions taking place between the various components of living cells. Recent “OMICS” technologies contribute large biological networks covering entire proteomes. These networks are generally static as they fail to capture spatial and temporal dimensions that represent essential properties of living systems. Mechanistic and dynamic insights often come from focused smaller-scale approaches, such as those used in structural biology, biophysics or cell biology.
This symposium brings together leading scientists from the “OMICS” field with leading structural and cell biologists to discuss scientific issues arising at the interface of these complementary fields. Possible avenues to populate current networks with dynamics and mechanistic insights that will ensure high levels of biological understanding and contribute to deciphering fundamental principles will be reviewed and investigated.