Location & dates EMBL Heidelberg, Germany 29 - 31 Mar 2015
Deadlines Registration closed Abstract submission closed

EMBL Courses and Conferences during the Coronavirus pandemic

With the onsite programme paused, many of our events are now being offered in virtual formats.

Registration is open as usual for many events, with back-up plans in place to move further courses and conferences online as necessary. Registration fees for any events affected by the COVID-19 disruption are fully refundable.

More information for participants of events at EMBL Heidelberg can be found here.

Conference Programme

Day 1 - Sunday 29 March 2015
11:30-14:15 Registration and lunch
12:00-13:00 Symposium Industry Workshop hosted by AMSBIO-Trevigen
14:15-14:30 Opening remarks

Session 1: Stem Cells in Cancer

14:30-15:00 Lgr5 Stem Cells in self-renewal and cancer
Hans C. Clevers, Hubrecht Institute, The Netherlands
15:00-15:30 Stem Cell Signals in Cancer Growth and Progression
Tannishtha Reya
, University of California, San Diego, USA
15:30-16:00 Hippo/YAP signalling in somatic stem cells and cancer
Fernando Camargo
, Boston Children's Hospital, Harvard University, USA
16:00-16:30 COFFEE BREAK
16:30-16:45 Cell Dynamics in Oesophageal Squamous Carcinogenesis
Julia Frede, University of Cambridge, UK

Wnt/b-Catenin and Epigenetic Signaling in Solid Cancer Stem Cells
Walter Birchmeier, Max-Delbrueck-Center (MDC), Germany

Keynote Lecture
17:00-18:00 Targeting developmental pathways in cancer
Frederic de Sauvage
, Genentech, USA
18:00-18:30 Poster Flash Talks: click here to see the list of presenters
18:30-20:00 Poster Session 1: numbers 40-112
20:00-23:30 Dinner in the EMBL Canteen and Drinks in the ATC Roof Top Lounge
Day 2 - Monday 30 March 2015

Session 2: Stem Cells, Cancer and Metastasis

09:00-09:30 Vascular cooption and latency mechanisms of metastatic stem cells
Joan Massagué
, Memorial Sloan-Kettering Cancer Center, USA
09:30-09:45 TGF-ß signalling in tumour heterogeneity and drug resistance of cancer stem cells
Naoki Oshimori, Rockefeller University, USA
09:45-10:15 Identification and therapeutic targeting of poor prognosis subtypes in colorectal cancer
Eduard Batlle
, Institute for Research in Biomedicine (IRB), Spain
10:15-10:30 Beug Foundation  Award Ceremony
10:30-11:00 COFFEE BREAK
11:00-11:30 Regulation of stem and progenitor cell function by the vasculature in bone
Ralf Adams
, Max Planck Institute for Molecular Biomedicine, Germany
11:30-11:45 Are human tumours addicted to stem cell pathways?
Austin Gurney
, OncoMed Pharmaceuticals, USA
11:45-12:00 Protocadherin-10 is a tumour suppressor for somatic stem cells
Frans van Roy, Guent University and  VIB, Belgium
12:00-12:30 Cancer cell of origin and tumour heterogeneity
Cedric Blanpain
, University of Brussels, Belgium
12:30-14:30 Lunch, 'Meet the speaker session' and poster viewing

Session 3: Stem Cell Signals, Ageing and Metabolism

14:30-15:00 Systemic regulation of aging phenotypes in mammalian tissues
Amy Wagers, Harvard Stem Cell Institute, Harvard University, USA
15:00-15:15 Mesenchymal status promotes metastatic colonisation via a cancer cell-stroma crosstalk which uncouples EMT and stemness
Ilaria Malanchi, CRUK, UK

Stepwise mutation of APC, P53, KRAS, and SMAD4 in human gut stem cells relieves dependency on discrete signals
Jarno Drost, Hubrecht Institute, The Netherlands

15:30-16:00 Molecular regulation of stem cell quiescence
Thomas A. Rando, Stanford University Medical Center, USA
16:00-16:30 COFFEE BREAK
16:30-17:00 Mechanisms of hematopoietic stem cell derived cancer
Karl Lenhard Rudolph, Leibniz Institute for Age Research - Fritz Lipmann Institute, Germany
17:00-17:15 Converging effectors of airway specification, regeneration, and lung cancer metastasis
Don Nguyen, Yale School of Medicine, USA
17:15-17:30 Diet-activated PPAR-delta enhances stemness and tumorigenicity of intestinal progenitor cells
Omer H. Yilmaz, Koch Institute/Massachusetts Institute of Technology, USA
17:30-18:00 Control of metabolic reprogramming by mitochondrial sirtuins
Marcia Haigis
, Harvard Medical School, USA
18:00-18:30 Poster Flash Talks: click here to see the list of presenters
18:30-20:00 Poster Session 2: numbers 113-183
20:00 Free evening
Day 3 - Tuesday 31 March 2015

Session 4: Non-Coding RNAs in Stem Cells

09:00-09:30 Alternative splicing in the regulation of planarian stem cells in vivo
Jordi Solana-Garcia
, Max Delbrück Center for Molecular Medicine, Germany
09:30-09:45 lncRNA maturation to initiate heterochromatin formation in the nucleolus is required for exit from pluripotency in ESCs
Raffaella Santoro, University of Zurich, Switzerland
09:45-10:00 Coordinate reprograming of residual hematopoietic function in the AML microenvironment
Peter Kurre, Oregon Health & Science University, USA
10:00-10:30 microRNA regulation in stem cells and cancer
Richard Gregory
, Harvard Stem Cell Institute, Harvard University, USA
10:30-11:00 COFFEE BREAK
11:00-11:15 Antithetical NFATc1-Sox2 and p53-miR200 signaling networks govern pancreatic cancer cell plasticity
Elisabeth Hessmann, University Medical Center Goettingen, Germany
11:15-11:30 Dissecting cellular reprogramming by mass spectrometry
Javier Muñoz, Spanish National Cancer Research Centre (CNIO), Spain
11:30-12:00 New roles for non-coding RNAs in ageing associated diseases and memory of patient age in iPSCs
Kristin Baldwin
, The Scripps Research Institute, USA
12:00-12:30 Stem cell function and sensitivity to genotoxic stress is controlled by protein translation rates
Michaela Frye, University of Cambridge, United Kingdom
12:30-14:30 Lunch, 'Meet the speaker session' and poster viewing
Session 5: Epigenetics and Cancer Genomics
14:30-15:00 Role of mutations in epigenetic regulators in pathogenesis of myeloid malignancies
Ross L. Levine, Memorial Sloan-Kettering Cancer Center, USA
15:00-15:15 Single cell genetics in leukaemia
Nicola Potter, The Institute of Cancer Research, UK

Physiologic stress drives accelerated aging of hematopoietic stem cells
Michael Milsom, HI-STEM, Germany

15:30-16:00 Cancer cell of origins influences the utilisation of self-renewal pathways and potential treatment response
Eric C.W. So
, King’s College London, UK
16:00-16:30 COFFEE BREAK
16:30-17:00 Stem Cell dormancy and Myc
Andreas Trumpp, German Cancer Research Center, Germany
17:00-17:30 Whole genome sequencing and comprehensive molecular profiling of gastric cancer
Suet Yi Leung, The University of Hong Kong, Hong Kong

Understanding estrogen receptor transcription in breast cancer
Jason Carroll
, Cancer Research UK Cambridge Institute, UK

Keynote Lecture
18:00-19:00 Mutational Processes in Normal & Cancer Cells
Michael Stratton
, Wellcome Trust Sanger Institute, UK
19:00-19:15 Poster prizes announcement
19:15-24:00 Conference Dinner and Party