Location & dates EMBL Heidelberg, Germany 7 - 10 Sep 2016
Deadlines Registration closed Abstract submission closed

EMBL Courses and Conferences during the Coronavirus pandemic

With the onsite programme paused, many of our events are now being offered in virtual formats.

Registration is open as usual for many events, with back-up plans in place to move further courses and conferences online as necessary. Registration fees for any events affected by the COVID-19 disruption are fully refundable.

More information for participants of events at EMBL Heidelberg can be found here.

Conference Programme

Day 1 - Wednesday 7 September 2016
TimeSpeaker and Title
11:00-13:00 Registration and lunch
12:50-13:00 Welcome remarks

Session 1: Actin in the nucleus
Chair: Laurent Blanchoin

13:00-13:25 Nuclear actin, gravity, and RNA/protein droplets
Clifford Brangwynne
, Princeton University, USA
13:25-13:50 Mechanical regulation of cell fate and positioning
Sara Annika Wickström
, Max Planck Institute for Biology of Ageing, Germany
13:50-14:05 Calcium Signaling Induces Arp2/3-mediated Actin Polymerization in the Nucleus to Trigger a Gene Expression Profile Required for T Lymphocyte Activation
Nikolaos Tsopoulidis, University Hospital Heidelberg, Germany
14:05-14:30 Structure and function of dynamic nuclear actin filament assembly
Robert Grosse
, University of Marburg, Germany
14:30-15:00 Coffee Break

Session 2: Mechanisms of nucleation
Chair: Peter Bieling

15:00-15:25 Mechanism of WASP-mediated activation of Arp2/3 complex
Brad Nolen
, University of Oregon, USA
15:25-15:40 Coordinated recruitment of Spir actin nucleators and myosin V motors to Rab11 vesicle membranes
Tobias Welz, University Hospital Regensburg, Germany
15:40-15:55 Sharpin promotes activity of the Arp2/3 complex
Siiri Salomaa, Turku Centre for Biotechnology, University of Turku
15:55-16:20 Different ways to disassemble actin filaments
Guillaume Romet-Lemonne
, Institut Jacques Monod, France
16:20-16:50 Flash Talks Session I
Twinfilin 1 regulates lamellipodial actin dynamics during cell migration
Markku Hakala, University of Helsinki, Finland
Diseases caused by mutations in human cytoplasmic actins
Nataliya Di Donato, Institute for Clinical Genetics, TU Dresden, Germany
Innate control of actin nucleation optimizes migration of immune cells in tissues
Pablo Vargas, Institut Curie, France
Formin Cdc12 acts as a myosin dependent mechanosensor that facilitates contractile ring assembly in fission yeast
Dennis Zimmermann, University of Chicago, United States of America
Amplification of actin polymerisation forces during yeast endocytosis
Serge Dmitrieff, EMBL Heidelberg, Germany
Biochemical characterization of Non Diaphanous Formin Delphilin
Priyanka Dutta, Indian Institute of Science Education and Research Pune, India
17:00-18:30 Poster session I:  Odd numbers
18:30-20:00 Dinner (EMBL Canteen)

Keynote Session
Introduced by Dyche Mullins
Chair: Buzz Baum

20:00-21:00 Analysis of Endocytosis and Cytokinesis by Biophysical Analysis and Quantitative Fluorescence Microscopy
Thomas D. Pollard
, Yale University, USA
21:00-23:00 Welcome reception (ATC Rooftop Lounge)

Day 2 - Thursday 8 September 2016
TimeSpeaker and Title

Session 3: In vitro reconstituted systems
Chair: Cecile Sykes

9:00-9:25 Architecture Dependence of Actin Filament Network Disassembly
nt Blanchoin, Biosciences and Bioengineering Institute, France
9:25-9:40 The dynamics of reconstituted cortical actin gels
Anne Bernheim-Groswasser, Ben-Gurion University of the Negev, Israel
9:40-9:55 Modulating formin activity with force
Mikael Kerleau, Institut Jacques Monod, France
9:55-10:20 Cytoskeletal form and function
Gijsje Koenderink, FOM Institute AMOLF, The Netherlands
10:20-10:35 Shape remodeling vesicles by localized actin polymerization
Katharina Henneberg, Technical University of Munich, Germany
10:35-11:00 Coffee Break
11:00-11:25 WASP-family proteins are distributive actin polymerases
Peter Bieling
, Max Planck Institute of Molecular Physiology, Germany
11:25-11:40 Reconstitution of endocytic actin networks on supported lipid bilayers
Emily Stoops, University of California Berkeley, USA
11:40-12:05 Isotropic Actomyosin Promotes Telescopic Contractility
Michael Murrell
, Yale University, USA
12:05-12:20 Active cargo positioning from actin-polarity sensing by small myosin assemblies
Pascal Martin, Institut Curie, PSL Research University, CNRS, France
12:20-13:30 Lunch (ATC Foyer)

Session 4: Actin in cell migration
Chair: Jan Faix

13:30-13:55 How much does it take to migrate: flows, squeezing, pressure, rupture and more
Matthieu Piel
, Curie Institute and CNRS, France
13:55-14:10 FMNL formins are required for lamellipodial force generation
Frieda Kage, Helmholtz Center for Infection Research, Germany
14:10-14:25 Two distinct actin networks mediate traction oscillations to confer mechanosensitivity of focal adhesions
Jian Liu, NIH, USA
14:25-14:50 Load adaptation of lamellipodial actin
Michael Sixt
, Institute of Science and Technology (IST), Austria
14:50-15:05 Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration
Alba Diz-Muñoz, EMBL Heidelberg, Germany
15:05-15:30 Making it, breaking it and retaining it: investigation of the evolutionarily divergent actin regulatory system of the malaria parasite
Jake Baum, Imperial College London, UK
15:30-16:00 Flash Talks Session II
Robust Gap Repair in the Contractile Ring Ensures Timely Completion of Cytokinesis
Ana Carvalho, i3S/IBMC, Portugal
Actin organization in cells responding to a perforated surface, revealed by live imaging and cryo electron tomography
Jasnin Marion, Max PIanck Institute of Biochemistry, Germany
Actin organization during collective epithelial cell sheet migration in PDMS microtubes
Surabhi Sonam, CNRS Institut Jacques Monod, France
Actomyosin Ring Formation and Maturation during Zebrafish Epiboly
Cornelia Schwayer, IST Austria, Austria
Cortical instability drives periodic supracellular actin pattern formation in epithelial tubes
Bo Dong, OUC, China
Recruitment of Arp2/3 complex via EhAK1 during phagocytosis in Entamoeba histolytica
Mrigya Babuta, Jawaharlal Nehru University, India
16:00-18:00 Poster Session II: Even numbers
18:00 Free evening (Optional: Boat Tour)

Day 3 - Friday 9 September 2016
TimeSpeaker and Title

Session 5: Actin in cell division
Chair: Peter Lenart

9:00-9:25 An actin spindle protects mammalian oocytes against chromosome segregation errors
Melina Schuh
Max Planck Institute for Biophysical Chemistry, Germany
9:25-9:40 F-actin depolymerization drives myosinII-independent contraction to transport chromosomes in starfish oocytes
Philippe Bun, EMBL Heidelberg, Germany
9:40-10:05 F-actin mechanics orchestrate the geometry of cell division in acentriolar oocytes and embryos
Marie-Emilie Terret, Collège de France, France
10:05-10:20 Localized F-actin depolymerization by the redox enzyme MICAL1 is essential  for successful cytokinetic abscission
Stéphane Frémont, Institut Pasteur, France
10:20-10:35 Cytoskeletal crosslinkers both drive and brake cytokinetic ring closure
Amy Maddox, UNC-Chapel Hill, USA
10:35-11:05 Coffee Break
11:05-11:20 Structure and constriction mechanism of the actomyosin ring
Lam Nguyen, California Institute of Technology, USA
11:20-11:35 Cortical flow aligns actin filaments to form a furrow
Anne-Cecile Reymann, Biotec TU Dresden, Germany
11:35-12:00 The cell cortex as an excitable medium
William Bement
, University of Wisconsin Madison, USA
12:00-13:30 Lunch (ATC Foyer)
Session 6: Mechanisms of contraction
Chair: François Nédélec

13:30-13:55 Controlling contractile instabilities in the actomyosin cortex
Stephan Grill
, MPI of Molecular Cell Biology and Genetics and TU Dresden, Germany
13:55-14:20 Spatiotemporal regulation of actomyosin contractility by RhoA
Ulrich Schwarz
, University of Heidelberg, Germany
14:20-14:45 Contractility in disordered actomyosin
Martin Lenz
, Paris-Sud University, France
14:45-15:00 A theory predicts contractions and extensions of disordered cytoskeletal networks
Julio Belmonte, EMBL Heidelberg, Germany
15:00-15:30 Coffee Break
Session 7: Actin‐membrane interactions
Chair: Alba Diz-Muñoz

15:30-15:55 Actin and microtubule crosstalk drive persistent polarized growth
Magdalena Bezanilla
, University of Massachusetts Amherst, USA
15:55-16:10 Live-cell super-resolution reveals F-actin and plasma membrane dynamics at the T cell synapse
George Ashdown, King's College London, UK
16:10-16:25 Ezrin regulation through MAL/SRF in cell blebbing and cell-in-cell invasion
Laura Soto Hinojosa, University of Marburg, Germany
16:25-16:40 Content release from large secretory vesicles is mediated by a dynamic acto-myosin network
Eyal Schejter, Weizmann Institute of Science, Israel
16:40-17:05 Gß regulates coupling between actin oscillators for cell polarity and directional migration
Orion Weiner
, University of California San Francisco, USA

Future of publishing panel discussion:
Publishing and Preprints - optimizing how we share reliable research
Bernd Pulverer, EMBO, Germany
Jessica Polka, ASAPbio
Thomas Lemberger, EMBO, Germany

17:05-19:40 Poster Session III: Odd & Even numbers
19:40-24:00 Dinner and Party

Day 4 - Saturday 10 September 2016
TimeSpeaker and Title
Session 8: Actin in a tissue and developmental context
Chair: Matthieu Piel


Actin Assembly and Organization in an Epithelial Cell
William Brieher
, University of Illinois, USA
9:25-9:40 Understanding the forces driving apical nuclear movements in different pseudostratified epithelia
Iskra Yanakieva, MPI-CBG, MPI-PKS, Germany
9:40-9:55 Environmental geometry and actin mechanics rule adhesion-free migration of leukocytes
Anne Reversat, Institute of Science and Technology, Austria
9:55-10-20 The Cytoskeletal Mechanics of Colliding Cells
Brian Stramer
, King's College London, UK
10:20-10:50 Coffee break
10:50-11:05 Endothelial actin dynamics during blood vessel lumen formation
Li-Kun Phng, National Cerebral and Cardiovascular Center, Japan
11:05-11:20 The logic and rules of actomyosin polarisation during Drosophila axis extension
Bénédicte Sanson, University of Cambridge, UK
11:20-11:45 Epithelial cell migration in gut homeostasis
Danijela Vignjevic
, Institut Curie and INSERM, France
Session 9: Evolution of the actin cytoskeleton
Chair: Guillaume Romet-Lemonne

11:45-12:10 Surprisingly diverse filament architectures of bacterial and archaeal actin-like filaments
Jan Löwe
, MRC Laboratory of Molecular Biology, UK
12:10-12:25 Toxoplasma gondii establishes an extensive filamentous network consisting of stable F-actin during replication
Javier Periz, Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, UK
12:25-12:40 Non-conserved amino acids of malaria parasite actin contribute to efficient gliding motility
Ross Douglas, Heidelberg University Medical School, Germany
12:40-13:05 Shape-sensing by MreB filaments to produce rod shape in Bacillus subtilis
Ethan Garner
, Harvard University, USA
13:05-13:15 Closing remarks
13:15 Packed lunch in ATC Foyer
13:45 Buses downtown and Frankfurt airport