Location & dates EMBL Heidelberg, Germany 13 - 16 Sep 2017
Deadlines Registration closed Abstract submission closed
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EMBL Courses and Conferences during the Coronavirus pandemic

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Conference Programme

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Day 1 - Wednesday 13 September 2017
TimeSpeaker
14.00 - 16.00 Arrival and Registration
16.00 - 16.15     

Welcome remarks

16.15 - 19.15    

Session 1 - Non-coding RNAs in prokaryotes
Chair: Jörg Vogel - Würzburg University, Germany

16.15 - 16.45     

Grad seq discovers the third domain of small RNA mediated gene regulation in bacteria
Jörg Vogel - Würzburg University, Germany

16.45 - 17.15     

From small RNAs to riboswitches and small ORFs: new concepts arising from studies in Listeria
Pascale Cossart - Institut Pasteur, France

17.15 - 17.45     

Coffee break
Meet the invited speakers:
Jörg Vogel, Pascale Cossart

17.45 - 18.15

CRISPR-Cas class-2 effector complexes – from biology to applications
John van der Oost - Wageningen University, The Netherlands

18.15 - 18.45

Cas9 Orthologs, their Natural “Anti-CRISPR” Inhibitors, and Applications in Subnuclear Proteomics
Erik Sontheimer - University of Massachusetts Medical School, USA

18.45 - 19.15

Accuracy versus efficiency of CRISPR Cas9 mediated gene editing
Jennifer A. Doudna - University of California, Berkeley, USA

19.30 Bus to Walking Tour Old Town Heidelberg leaves from EMBL Bus Stop (Place is full)
Day 2 - Thursday 14 September  2017
TimeSpeaker
09.00 - 12.30 Session 2 - miRNAs function and mechanisms I

Chair: Irene Bozzoni - Sapienza University, Italy
09.00 - 09.15 Avoidance of crosstalk RNA interactions in prokaryotes
Sinan Ugu Umu - Cancer Registry of Norway, Norway
09.15 - 09.45      Beyond the Seed: Structural Basis for Non canonical miRNA: Target Interactions
Ian MacRae - The Scripps Research Institute, USA
09.45 - 10.00      Endogenous transcripts control miRNA levels and activity in mammalian cells by a target-induced miRNA degradation mechanism (TIMD)
Francesco Nicassio - Istituto Italiano di Tecnologia, Italy
10.00 - 10.45     

Coffee break
Meet the invited speakers: John van der Oost, Erik Sontheimer, Jennifer A. Doudna, Ian MacRae

10.45 - 11.15 MicroRNAs and other regulatory RNAs
David Bartel - HHMI/MIT/Whitehead Institute, USA
11.15 - 11.45

The control of muscle differentiation: from coding to noncoding RNA and back
Irene Bozzoni - Sapienza University, Italy

11.45 - 12.00 MicroRNA biogenesis is regulated by PRMT1-dependent methylation of the Large Drosha Complex
Valeria Spadotto - European Institute of Oncology - IEO, Milan, Italy
12.00 - 12.15 Birth, life and death of a miRNA-directed mRNP
Thomas F. Duchaine - McGill University, Canada
12.15 - 12.30 Unraveling novel miRNA functions through single cell sequencing
Marcel Tarbier - Stockholm University, Sweden
12.30 - 14.00 Lunch
14.00 - 17.15 Session 3 - miRNAs function and mechanisms 2
Chair: David Bartel - HHMI/MIT/Whitehead Institute, USA
14.00 - 14.30 To be presented onsite
V. Narry Kim - Seoul National University, South Korea
14.30 - 15.00 RNA modification and the immortal lineage
Donal O’Carroll - MRC Centre for Regenerative Medicine, The University of Edinburgh, UK
15.00 - 15.15 Delivery of stable microRNA mimics to alleviate neurodegenerative or metabolic phenotypes in mice
Ilya Vinnikov - Shanghai Jiao Tong University, China
15.15 - 15.30 ZDHHC11 and ZDHHC11B are novel critical components of the oncogenic MYC-miR-150-MYB network in Burkitt lymphoma
Agnieszka Dzikiewicz-Krawczyk - Institute of Human Genetics, Polish Academy of Sciences, Poland
15.30 - 15.45 Flash Talks
16.00 - 18.00 Poster session I - Odd Numbers
18.00 - 20.30   Dinner
20.30 - 23.00  After Dinner Get Together with live music
Day 3 - Friday 15 September  2017
TimeSpeaker
09.00 - 12.15 Session 4 - piRNAs: Biogenesis and function
Chair: Mikiko Siomi - University of Tokyo, Japan
09.00 - 09.30

To be presented onsite
Gregory Hannon, Cancer Research UK – Cambridge Institute, UK

09.30 - 10.00 Molecular mechanism of piRNA biogenesis
Mikiko Siomi, University of Tokyo, Japan
10.00 - 10.15 Pan-arthropod analysis reveals somatic piRNAs as an ancestral TE defence
Samuel Lewis, University of Cambridge, United Kingdom
10.15 - 10.45 Coffee break kindly sponsored by Nature Reviews Genetics
Meet the invited speakers: David Bartel, Irene Bozzoni, V. Narry Kim, Donal O’Carroll, Gregory Hannon, Mikiko Siomi
10.45 - 11.15 piRNA cluster biology
Julius Brennecke, IMBA - Institute of Molecular Biotechnology GmbH, Austria
11.15 - 11.30 piRNA processing is triggered by recruitment to the cytoplasmic processing machinery
Katalin Fejes Toth, California Institute of Technology, USA
11.30 - 11.45 Defining Mouse Pachytene piRNA Function In Vivo
Pei-Hsuan Wu, University of Massachusetts Medical School; Howard Hughes Medical Institute, USA
11.45 - 12.00 Processing of RNAs at DNA Double Strand Breaks
Franziska Bonath, The Wenner Grenn Institute, Stockholm University, Sweden
12.00 - 12.15 Crosstalk mechanisms between microRNAs and the ribosome and their role in mammalian immunity
Dimitris Lagos, University of York, UK
12.15 - 14.00 Lunch
12.45 - 13.45 Meet the Editors - Courtyard Room A and B (The room capacity is 80 people in total).
  1. Maria Polychronidou - Molecular Systems Biology – EMBO
  2. Anne Nielsen - The EMBO Journal
  3. Esther Schnapp - EMBO Reports
  4. Steve Mao - AAAS/Science
  5. Linda Koch - Springer Nature
  6. Sarah Geissler - Cell Press
  7. Andrew Moore - Wiley-VCH
  8. Xiaolei Liu, Cell Research, China
14.00 - 17.15 Session 5 - siRNAs and/or transcriptional gene silencing 

Chair: Asifa Akhtar, MPI of Immunobiology and Epigenetic, Germany
14.00 - 14.30

Epigenetic genome control by non-coding RNAs and RNA processing factors
Shiv Grewal, National Institutes of Health/National Cancer Institute, USA

14.30 - 15.00

DHX9 suppresses RNA processing defects originating
from the Alu invasion of human genome
Asifa Akhtar, MPI of Immunobiology and Epigenetic, Germany

15.00 - 15.15

RNAcentral: Developing the Non-coding RNA Sequence Database
Blake Sweeney - EMBL-EBI, UK

15.15 - 15.45 Coffee break kindly sponsored by Nature Reviews Genetics
Meet the invited speakers: Julius Brennecke, Shiv Grewal, Asifa Akhtar
15.45 - 16.15

Non coding RNAs involved in RNA-directed DNA methylation
Steve Jacobsen, University of California, Los Angeles, USA

16.15 - 16.45

Small RNAs as mobile, morphogen-like signals in development
Marja Timmermans, University of Tübingen, Germany

16.45 - 17.00 NBS-LRR deriving sRNAs uniquely in nuclear-replicating virus-infected tomato plants target components of the photosynthetic machinery
Michela Chiumenti, Institute for Sustainable Plant Protection, Italy
17.00 - 17.15 Flash Talks
17.15 – 19.15 Poster session II - Even Numbers
19.15 - 21.00 Conference Special Dinner 
21.00 - 24.00 Conference party with live band
Day 4 - Saturday 16 September 2017
TimeSpeaker
09.00 - 12.15 Session 6 -  Long non-coding RNAs 1
Chair: Joshua Mendell, University of Texas Southwestern Medical Center, USA
09.00 - 09.30 How a lncRNA shapes chromatin structure to control gene expression
Mitchell Guttmann - California Institute of Technology, USA
09.30 - 10.00 Antisense-mediated chromatin silencing at FLC
Caroline Dean - John Innes Centre, Norwich Research Park, UK
10.00 - 10.15 The long noncoding RNA SPRIGHTLY acts as an intra-nuclear organizing hub for pre-mRNA molecules
Ranjan J. Perera - Sanford Burnham Prebys Medical Discovery Institute, USA
10.15 - 10.45 Coffee break
Meet the invited speakers:
Steve Jacobsen, Marja Timmermans, Mitchell Guttmann, Caroline Dean
10.45 - 11.15

Long non-coding RNAs (lncRNAs) in neural development 36
Daniel Lim - University of California, San Francisco, USA

11.15 - 11.45 Molecular and Physiological functions of circRNAs
Sebastian Kadener - The Hebrew University of Jerusalem, Israel and Brandeis University, USA
11.45 - 12.00 Knocking out Cdr1as, a conserved mammalian circular RNA, causes miRNA deregulation and a neuropsychiatric phenotype in mice
Monika Piwecka - Max Delbrück Center for Molecular Medicine, Germany
12.00 - 12.15 Circular RNA ZNF609 promotes the progression of colorectal cancer
Hung Ho Xuan - University of Regensburg, Germany
12.15 - 14.00 Lunch
14.00 - 17.15 Session 7 - Long non-coding RNAs 2
Chair: Mitchell Guttmann - California Institute of Technology, USA
14.00 - 14.30 Regulation and function of mammalian noncoding RNAs
Joshua Mendell - University of Texas Southwestern Medical Center, USA
14.30 - 14.45 Sequences enriched in Alu repeats drive nuclear localization of long RNAs in human cells
Igor Ulitsky - Weizmann Institute of Science, Israel
14.45 - 15.00 Epigentic regulation of pericentromeric satellite RNA and its consequences on mRNA splicing, stress response and disease development
Michelle Hussong - University Hospital Cologne International, Germany
15.00 -15.15 Dynamic Expression of tRNA-derived Small RNAs (tsRNAs) Define Cell States
Srikar Krishna Gopinath, Institute for Stem Cell biology and Regenerative Medicine (inStem), India
15.15 - 15.45 Coffee break
Meet the invited speakers:
Daniel Lim, Sebastian Kadener, Joshua Mendell, John L. Rinn
15.45 - 16.00 The small non-coding vault RNA1-1 acts as a riboregulator of p62-mediated autophagy
Rastislav Horos - EMBL Heidelberg, Germany
16.00 - 16.15

RNAi in bacteria: mechanisms of guide RNA generation and target recognition
Daria Esyunina - Russian Academy of Sciences, Division of Biology and
Biological Engineering California Institute of Technology, Russian Federation

16.15 - 16.30 Characterization of a novel factor involved in transgenerational silencing in C.elegans
Maria Placentino - Institute of Molecular Biology (IMB), Germany
16.30 - 17.00

TAD boundary organization at the Firre locus occurs independently of CTCF binding and lncRNA transcription
John L. Rinn - Harvard Medical School, USA

17.00 - 17.10 Concluding remarks