Conference Programme

Location & dates EMBL Heidelberg, Germany 13 - 16 Sep 2017

Deadlines Registration closed Abstract submission closed

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Day 1 - Wednesday 13 September 2017
Time	Speaker
14.00 - 16.00	Arrival and Registration
16.00 - 16.15	Welcome remarks
16.15 - 19.15	Session 1 - Non-coding RNAs in prokaryotes Chair: Jörg Vogel - Würzburg University, Germany
16.15 - 16.45	Grad seq discovers the third domain of small RNA mediated gene regulation in bacteria Jörg Vogel - Würzburg University, Germany
16.45 - 17.15	From small RNAs to riboswitches and small ORFs: new concepts arising from studies in Listeria Pascale Cossart - Institut Pasteur, France
17.15 - 17.45	Coffee break Meet the invited speakers: Jörg Vogel, Pascale Cossart
17.45 - 18.15	CRISPR-Cas class-2 effector complexes – from biology to applications John van der Oost - Wageningen University, The Netherlands
18.15 - 18.45	Cas9 Orthologs, their Natural “Anti-CRISPR” Inhibitors, and Applications in Subnuclear Proteomics Erik Sontheimer - University of Massachusetts Medical School, USA
18.45 - 19.15	Accuracy versus efficiency of CRISPR Cas9 mediated gene editing Jennifer A. Doudna - University of California, Berkeley, USA
19.30	Bus to Walking Tour Old Town Heidelberg leaves from EMBL Bus Stop (Place is full)

Day 2 - Thursday 14 September 2017
Time	Speaker
09.00 - 12.30	Session 2 - miRNAs function and mechanisms I  Chair: Irene Bozzoni - Sapienza University, Italy
09.00 - 09.15	Avoidance of crosstalk RNA interactions in prokaryotes Sinan Ugu Umu - Cancer Registry of Norway, Norway
09.15 - 09.45	Beyond the Seed: Structural Basis for Non canonical miRNA: Target Interactions Ian MacRae - The Scripps Research Institute, USA
09.45 - 10.00	Endogenous transcripts control miRNA levels and activity in mammalian cells by a target-induced miRNA degradation mechanism (TIMD) Francesco Nicassio - Istituto Italiano di Tecnologia, Italy
10.00 - 10.45	Coffee break Meet the invited speakers: John van der Oost, Erik Sontheimer, Jennifer A. Doudna, Ian MacRae
10.45 - 11.15	MicroRNAs and other regulatory RNAs David Bartel - HHMI/MIT/Whitehead Institute, USA
11.15 - 11.45	The control of muscle differentiation: from coding to noncoding RNA and back Irene Bozzoni - Sapienza University, Italy
11.45 - 12.00	MicroRNA biogenesis is regulated by PRMT1-dependent methylation of the Large Drosha Complex Valeria Spadotto - European Institute of Oncology - IEO, Milan, Italy
12.00 - 12.15	Birth, life and death of a miRNA-directed mRNP Thomas F. Duchaine - McGill University, Canada
12.15 - 12.30	Unraveling novel miRNA functions through single cell sequencing Marcel Tarbier - Stockholm University, Sweden
12.30 - 14.00	Lunch
14.00 - 17.15	Session 3 - miRNAs function and mechanisms 2 Chair: David Bartel - HHMI/MIT/Whitehead Institute, USA
14.00 - 14.30	To be presented onsite V. Narry Kim - Seoul National University, South Korea
14.30 - 15.00	RNA modification and the immortal lineage Donal O’Carroll - MRC Centre for Regenerative Medicine, The University of Edinburgh, UK
15.00 - 15.15	Delivery of stable microRNA mimics to alleviate neurodegenerative or metabolic phenotypes in mice Ilya Vinnikov - Shanghai Jiao Tong University, China
15.15 - 15.30	ZDHHC11 and ZDHHC11B are novel critical components of the oncogenic MYC-miR-150-MYB network in Burkitt lymphoma Agnieszka Dzikiewicz-Krawczyk - Institute of Human Genetics, Polish Academy of Sciences, Poland
15.30 - 15.45	Flash Talks
16.00 - 18.00	Poster session I - Odd Numbers
18.00 - 20.30	Dinner
20.30 - 23.00	After Dinner Get Together with live music

Day 3 - Friday 15 September 2017
Time	Speaker
09.00 - 12.15	Session 4 - piRNAs: Biogenesis and function Chair: Mikiko Siomi - University of Tokyo, Japan
09.00 - 09.30	To be presented onsite Gregory Hannon, Cancer Research UK – Cambridge Institute, UK
09.30 - 10.00	Molecular mechanism of piRNA biogenesis Mikiko Siomi, University of Tokyo, Japan
10.00 - 10.15	Pan-arthropod analysis reveals somatic piRNAs as an ancestral TE defence Samuel Lewis, University of Cambridge, United Kingdom
10.15 - 10.45	Coffee break kindly sponsored by Nature Reviews Genetics Meet the invited speakers: David Bartel, Irene Bozzoni, V. Narry Kim, Donal O’Carroll, Gregory Hannon, Mikiko Siomi
10.45 - 11.15	piRNA cluster biology Julius Brennecke, IMBA - Institute of Molecular Biotechnology GmbH, Austria
11.15 - 11.30	piRNA processing is triggered by recruitment to the cytoplasmic processing machinery Katalin Fejes Toth, California Institute of Technology, USA
11.30 - 11.45	Defining Mouse Pachytene piRNA Function In Vivo Pei-Hsuan Wu, University of Massachusetts Medical School; Howard Hughes Medical Institute, USA
11.45 - 12.00	Processing of RNAs at DNA Double Strand Breaks Franziska Bonath, The Wenner Grenn Institute, Stockholm University, Sweden
12.00 - 12.15	Crosstalk mechanisms between microRNAs and the ribosome and their role in mammalian immunity Dimitris Lagos, University of York, UK
12.15 - 14.00	Lunch
12.45 - 13.45	Meet the Editors - Courtyard Room A and B (The room capacity is 80 people in total). Maria Polychronidou - Molecular Systems Biology – EMBO Anne Nielsen - The EMBO Journal Esther Schnapp - EMBO Reports Steve Mao - AAAS/Science Linda Koch - Springer Nature Sarah Geissler - Cell Press Andrew Moore - Wiley-VCH Xiaolei Liu, Cell Research, China
14.00 - 17.15	Session 5 - siRNAs and/or transcriptional gene silencing   Chair: Asifa Akhtar, MPI of Immunobiology and Epigenetic, Germany
14.00 - 14.30	Epigenetic genome control by non-coding RNAs and RNA processing factors Shiv Grewal, National Institutes of Health/National Cancer Institute, USA
14.30 - 15.00	DHX9 suppresses RNA processing defects originating from the Alu invasion of human genome Asifa Akhtar, MPI of Immunobiology and Epigenetic, Germany
15.00 - 15.15	RNAcentral: Developing the Non-coding RNA Sequence Database Blake Sweeney - EMBL-EBI, UK
15.15 - 15.45	Coffee break kindly sponsored by Nature Reviews Genetics Meet the invited speakers: Julius Brennecke, Shiv Grewal, Asifa Akhtar
15.45 - 16.15	Non coding RNAs involved in RNA-directed DNA methylation Steve Jacobsen, University of California, Los Angeles, USA
16.15 - 16.45	Small RNAs as mobile, morphogen-like signals in development Marja Timmermans, University of Tübingen, Germany
16.45 - 17.00	NBS-LRR deriving sRNAs uniquely in nuclear-replicating virus-infected tomato plants target components of the photosynthetic machinery Michela Chiumenti, Institute for Sustainable Plant Protection, Italy
17.00 - 17.15	Flash Talks
17.15 – 19.15	Poster session II - Even Numbers
19.15 - 21.00	Conference Special Dinner
21.00 - 24.00	Conference party with live band

Day 4 - Saturday 16 September 2017
Time	Speaker
09.00 - 12.15	Session 6 - Long non-coding RNAs 1 Chair: Joshua Mendell, University of Texas Southwestern Medical Center, USA
09.00 - 09.30	How a lncRNA shapes chromatin structure to control gene expression Mitchell Guttmann - California Institute of Technology, USA
09.30 - 10.00	Antisense-mediated chromatin silencing at FLC Caroline Dean - John Innes Centre, Norwich Research Park, UK
10.00 - 10.15	The long noncoding RNA SPRIGHTLY acts as an intra-nuclear organizing hub for pre-mRNA molecules Ranjan J. Perera - Sanford Burnham Prebys Medical Discovery Institute, USA
10.15 - 10.45	Coffee break Meet the invited speakers: Steve Jacobsen, Marja Timmermans, Mitchell Guttmann, Caroline Dean
10.45 - 11.15	Long non-coding RNAs (lncRNAs) in neural development 36 Daniel Lim - University of California, San Francisco, USA
11.15 - 11.45	Molecular and Physiological functions of circRNAs Sebastian Kadener - The Hebrew University of Jerusalem, Israel and Brandeis University, USA
11.45 - 12.00	Knocking out Cdr1as, a conserved mammalian circular RNA, causes miRNA deregulation and a neuropsychiatric phenotype in mice Monika Piwecka - Max Delbrück Center for Molecular Medicine, Germany
12.00 - 12.15	Circular RNA ZNF609 promotes the progression of colorectal cancer Hung Ho Xuan - University of Regensburg, Germany
12.15 - 14.00	Lunch
14.00 - 17.15	Session 7 - Long non-coding RNAs 2  Chair: Mitchell Guttmann - California Institute of Technology, USA
14.00 - 14.30	Regulation and function of mammalian noncoding RNAs Joshua Mendell - University of Texas Southwestern Medical Center, USA
14.30 - 14.45	Sequences enriched in Alu repeats drive nuclear localization of long RNAs in human cells Igor Ulitsky - Weizmann Institute of Science, Israel
14.45 - 15.00	Epigentic regulation of pericentromeric satellite RNA and its consequences on mRNA splicing, stress response and disease development Michelle Hussong - University Hospital Cologne International, Germany
15.00 -15.15	Dynamic Expression of tRNA-derived Small RNAs (tsRNAs) Define Cell States Srikar Krishna Gopinath, Institute for Stem Cell biology and Regenerative Medicine (inStem), India
15.15 - 15.45	Coffee break Meet the invited speakers: Daniel Lim, Sebastian Kadener, Joshua Mendell, John L. Rinn
15.45 - 16.00	The small non-coding vault RNA1-1 acts as a riboregulator of p62-mediated autophagy Rastislav Horos - EMBL Heidelberg, Germany
16.00 - 16.15	RNAi in bacteria: mechanisms of guide RNA generation and target recognition Daria Esyunina - Russian Academy of Sciences, Division of Biology and Biological Engineering California Institute of Technology, Russian Federation
16.15 - 16.30	Characterization of a novel factor involved in transgenerational silencing in C.elegans Maria Placentino - Institute of Molecular Biology (IMB), Germany
16.30 - 17.00	TAD boundary organization at the Firre locus occurs independently of CTCF binding and lncRNA transcription John L. Rinn - Harvard Medical School, USA
17.00 - 17.10	Concluding remarks