Location & dates EMBL Heidelberg, Germany 7 - 10 May 2018
Deadlines Registration closed Abstract submission closed


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Day 1 - Monday 7 May 2018
11:30 - 13:15 Registration and Lunch
13:15 - 13:30 Opening remarks
13:30 - 14:30 Mechanisms and Regulation of Eukaryotic Replication Initiation
KEYNOTE: Stephen Bell, Massachusetts Institute of Technology, USA
Session 1: Initiation of DNA Replication
Chairs: John Diffley and Thanos Halazonetis
14:30 - 15:00

Formation of bidirectional replication forks at origins
Hiroyuki ArakiNational Institute of Genetics, Japan

15:00 - 15:30

Structural mechanisms for initiating DNA replication
James BergerJohns Hopkins School of Medicine, USA

15:30 - 16:00

Conformational control and DNA binding mechanism of the metazoan origin recognition complex
Franziska Bleichert, Friedrich Miescher Institute for Biomedical Research, Switzerland

16:00 - 16:30

Coffee Break

16:30 - 17:00

CDK misregulation inhibits loading of the replicative helicase to generate replicative stress
John DiffleyThe Francis Crick Institute, UK

17:00 - 17:15

Eukaryotic replisome assembly and fork progression visualized by cryo-EM
Alessandro Costa, The Francis Crick Institute, UK

17:15 - 17:30

Establishing leading-strand synthesis at eukaryotic DNA replication forks
Joseph Yeeles, MRC Laboratory of Molecular Biology, UK

17:30 - 17:45

Structural basis of replicative helicase recruitment by ORC, Cdc6 and Cdt1
Christian Speck, Imperial College London, UK

17:45 -18:00

Coordination of DNA damage tolerance in human cells: pathway choice gives priority to replication continuity
Emmanuelle Despras, CNRS, France

18:00 - 18:15

The role of the AAA+ ATPase WRNIP1 in the protection of stalled replication forks
Kerstin Gari, University of Zurich, Switzerland

18:15 - 20:15


20:15 - 22:00

After Dinner Drinks and Welcome Reception in the ATC Rooftop Lounge

Day 2 - Tuesday 8 May 2018

Session 2: Replication Origins and Timing of Firing
Chair: Michelle Debatisse

09:00 - 09:30

Characterization and activation of metazoan DNA replication origins

Marcel MechaliInstitute of Human Genetics,  CNRS-University of Montpellier France

09:30 - 10:00

Determinants of replication origins in vertebrate cells
Marie-Noelle PrioleauUniversity Paris Diderot-CNRS, France

10:00 - 10:30 Identification of cis elements for spatio temporal control of DNA replication
David GilbertFlorida State University, USA
10:30 - 11:00 Coffee Break
11:00 - 11:30

A conserved role for RIF1 in protecting nascent DNA at stalled replication forks
Anne DonaldsonUniversity of Aberdeen, UK

11:30 - 11:45

Rif1 a hub connecting nuclear architecture and replication timing
Sara Buonomo, University of Edinburgh, UK

11:45 - 12:00

Replication incompleteness under replication stress is crucial to CFS instability
Chun-Long Chen, Institut Curie, France

12:00 - 14:00 Lunch and meet the speakers
13:00 - 13:45

ERC Workshop: All you need to know before applying
Ino Agrafioti, European Research Council, Belgium

Session 3: Replication Forks and Termination of DNA Replication
Chair: Ian Hickson

14:00 - 14:30 Directionality of CMG translocation provides origin quality control and single molecule studies of CMG reveal mechanisms of replication restart and replisome preservation at collapsed forks
Michael O'DonnellThe Rockefeller University, USA
14:30 - 15:00 Destroying the eukaryotic replisome
Karim LabibUniversity of Dundee, UK
15:00 - 15:30 Coordinating DNA Replication Termination with Mitotic Entry
Oscar Fernandez-CapetilloSpanish National Cancer Research Centre, Spain
15:30 - 16:00 Coffee Break
16:00 - 16:15

Replisome disassembly in vertebrates
Aga Gambus, University of Birmingham, UK

16:15 - 16:30

Roles of checkpoint-dependent inhibition of origin firing after replication stress
Esther Cabañas Morafraile, University of Cambridge, UK

16:30 - 16:45

A DNA replication-dependent feed-forward loop determines CDK1 and PLK1 activation
Bennie Lemmens, Karolinska Institutet, Sweden

16:45 - 17:00

Reconstituting DNA replication termination with purified proteins
Tom Deegan, University of Dundee, UK

17:00 - 19:00

Poster Session I (odd numbers)
ATC Helix A

19:00 - 21:00 Dinner
21:00 - 23:00 After Dinner Drinks in the ATC Rooftop Lounge
Day 3 - Wednesday 9 May 2018
8:15 - 9:00

Career Workshop:
Moderated by Thanos Halazonetis
Speakers: Genevieve Almouzni, John Diffley, Susan Gasser, Karim Labib
Meeting Room Helix A

Session 4: Transcription, Chromatin and Replication
Chair: Sarah Lambert
09:00 - 09:30 Building chromatin: histone variants and chaperones at work
Genevieve AlmouzniInstitut Curie, France
09:30 - 10:00

Transcription replication conflicts: R loops as obstacles to replication fork progression

Andres AguileraUniversity of Seville, Spain

10:00 - 10:30

DNA replication and transcription in early development

Iestyn WhitehouseMemorial Sloan Kettering Cancer Center, USA

10:30 - 11:00 Coffee Break
11:00 - 11:15

Genome-wide control of heterochromatin replication by the telomeric protein TRF2
Eric Gilson, University of Nice, France

11:15 - 11:30 MRX, Set1 and Gcn5 modulate chromatin structure at stalled replication forks  to promote resection of nascent DNA and cohesin loading
Philippe Pasero, CNRS, France
11:30 - 11:45 Epigenetic regulation of replication origins
Vincenzo Costanzo, F.I.R.C. Institute of Molecular Oncology, Italy
11:45 - 12:00

Mechanism of replication completion after mitotic entry in cells with under-replicated DNA
Etienne Schwob, IGMM, CNRS, France

12:00 - 14:00 Lunch and meet the speakers
14:00 - 15:00

Chromatin replication and epigenome maintenance
KEYNOTE: Anja GrothUniversity of Copenhagen, Denmark

Session 5: DNA Replication Stress - Basic Mechanisms
Chair: Anne Donaldson
15:00 - 15:30 DDK mediated regulation of the deSUMOylating enzyme Ulp2 facilitates early steps of DNA replication
Dana BranzeiF.I.R.C. Institute of Molecular Oncology, Italy
15:30 - 16:00

Active role of histone deposition during replication fork restart
Sarah LambertInstitut Curie, France

16:00 - 16:30 Coffee Break
16:30 - 17:00 Replication licensing aberrations as a source of genome plasticity
Zoi Lygerou, University of Patras, Greece
17:00 - 17:15

Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48
Joanna Loizou, CeMM, Austria

17:15 - 17:30

Replication Initiation Zones are Preferential Sites of Replication Fork Collapse
Anthony Tubbs, National Institutes of Health, USA

17:30 - 19:30

Poster Session II (even numbers)
ATC Helix A

19:30 - 21:00

Conference Dinner
EMBL Canteen and terrace

21:00 - 24:00 Conference Party
EMBL Canteen
Day 4 - Thursday 10 May 2018
Session 6: DNA Replication Stress and Cancer 
Chair: Oscar Fernandez-Capetillo
09:00 - 09:30 Common fragile site instability: a race against time
Michelle DebatisseGustave Roussy, France
09:30 - 10:00

Replication stress: Mechanisms, pathway cross talks and cancer treatment
Jiri BartekDanish Cancer Society, Denmark

10:00 - 10:30 H3K9me2 and BRCA1 prevent satellite repeat transcription, R loops and germline sterility: roles for replication stress
Susan GasserFriedrich Miescher Institute for Biomedical Research, Switzerland
10:30 - 11:00 Coffee Break
11:00 - 11:30 Mechanism of replication at common fragile sites
Ian HicksonUniversity of Copenhagen, Denmark
11:30 - 12:00 Mechanisms of oncogene-induced DNA replication stress
Thanos HalazonetisUniversity of Geneva, Switzerland
12:00 - 12:15 New regulatory pathway for BRCA1-mediated fork protection
Jo Morris, University of Birmingham, UK
12:15 - 12:30 Replication-associated damage at genomic ribonucleotides provides a therapeutic vulnerability to PARP inhibitors
Olga Murina, IGMM, University of Edinburgh, UK
12:30 - 12:45 CMG ubiquitylation is a DNA damage signal that activates two distinct ICL repair pathways
Daniel Semlow, Harvard Medical School, USA
12:45 - 13:00

Closing Remarks and Poster Prize
Thanos Halazonetis, University of Geneva, Switzerland

13:00 - 13:15 Packed Lunch
13:30 Bus Departure
ATC Bus Stop