Conference Programme

Location & dates EMBL Heidelberg, Germany 3 - 6 Oct 2018

Deadlines Registration closed Abstract submission closed

EMBL Courses and Conferences during the Coronavirus pandemic

With the onsite programme paused, many of our events are now being offered in virtual formats.

Registration is open as usual for many events, with back-up plans in place to move further courses and conferences online as necessary. Registration fees for any events affected by the COVID-19 disruption are fully refundable.

More information for participants of events at EMBL Heidelberg can be found here.

Day 1 - Wednesday 3 October 2018
Time	Speaker
15:00-17:45	Arrival and Registration
17:45-19:00	Welcome Dinner
Session 1: Keynote Session 19:00 - 20:45
19:00-19:15	Welcome Remarks
19:15-20:00	Keynote Talk 1: Reinhard Lührmann Novel mechanistic insights into the inner workings of the human spliceosome by combined biochemical and Cryo-EM studies Max Planck Institute for Biophysical Chemistry, Germany
20:00-20:45	Keynote Talk 2: Geraldine Seydoux Regulation of RNA granule dynamics by intrinsically-disordered proteins Johns Hopkins University School of Medicine, USA
20:45-23:00	Drinks and Poster "Sneak Preview"

Day 2 - Thursday 4 October 2018
Time	Speaker
Session 2: Splicing and RNPs 09:00-12:35 Chair: Kathi Zarnack
09:00-09:25	Complex Interactions between Transcription, Splicing and Chromatin Jean Beggs, University of Edinburgh, UK
09:25-09:50	Splicing-dependent regulation of transcription start sites Christopher B. Burge, Massachusetts Institute of Technology, USA
09:50-10:15	CryoEM snapshots of the spliceosome provide insights into the molecular mechanism of pre-mRNA splicing Kiyoshi Nagai, MRC Laboratory of Molecular Biology, UK
10:15-10:45	Coffee Break
10:45-11:10	Quantitative Activity Profile and Context-Dependence of all Human 5’ Splice Sites Adrian R. Krainer, Cold Spring Harbor Laboratory, USA
11:10-11:25	Global two-step pre-mRNA splicing kinetics in human cells Selected Talk: Leonhard Wachutka, TUM Germany
11:25-11:40	Self-regulatory network of the core spliceosome Selected Talk: Malgorzata Ewa Rogalska, CRG-Centre for Genomic Regulation, Universitat Pompeu Fabra, Spain
11:40-11:55	Systematic Identification and Quantitative Measurement of RNA-Protein Interactions by incPRINT Selected Talk: Alena Shkumatava, Institut Curie, France
11:55-12:20	Hidden treasures of the RNA world: RBPs from moonlighting to riboregulation Matthias Hentze, EMBL Heidelberg, Germany
12:20-12:35	Flash Talks: Talks selected from abstracts #57,133, 149, 233, 251 (1 slide / 2 min each)
12:35-16:00	Lunch & Poster session I (odd numbers)
Session 3: RNA modifications and features determining transcript fate 16:00 - 19:00 Chair: John Gross
16:00-16:25	RNA methylation in gene expression regulation Chuan He, The University of Chicago, USA
16:25-16:50	The regulatory potential of cytosine-5 RNA methylation in translation Michaela Frye, University of Cambridge, UK
16:50-17:15	Pseudouridine synthases modify human pre-mRNA co-transcriptionally and affect splicing Wendy Gilbert, Yale University, USA
17:15-17:30	Methylation of structured RNA by the m⁶A writer METTL16 is essential for mouse embryonic development Selected Talk: Mateusz Mendel
17:30-18:00	Coffee Break
18:00-18:15	Unraveling the link between translation termination and nonsense-mediated mRNA decay Selected Talk: Oliver Mühlemann
18:15-18:30	Codon and amino acid use is a major determinant of mRNA stability in humans Selected Talk: Olivia Rissland, University of Colorado, USA
18:30-18:45	Post-transcriptional regulation in T cell responses to infection and tumors is time- and context-dependent Selected Talk: Monika Wolkers, Sanquin Research, Landsteiner Laboratory, The Netherlands
18:45-19:00	Identification of a cyclin-dependent kinase coupling global protein synthesis rates with cell proliferation and growth Selected Talk: Katharina Haneke, Medical Faculty Mannheim, Germany
19:00-21:00	Pre-Dinner Drinks and Dinner EMBL Canteen
21:00-23:00	After Dinner Drinks ATC Rooftop Lounge

Day 3 - Friday 5 October 2018
Time	Speaker
Session 4: RNA localization and translation 09:00-13:00 Chair: Nicola Gray
09:00-09:45	Keynote Talk 3: Robert H. Singer: Watching single mRNAs form memories Albert Einstein College of Medicine, USA
09:45-10:10	Imaging the life and death of mRNAs in single cells Jeffrey A. Chao, Friedrich Miescher Institute for Biomedical Research, Switzerland
10:10-10:35	Uncovering rules and dynamics of nonsense-mediated mRNA decay using single molecule imaging Marvin Tanenbaum, Hubrecht Institute, The Netherlands
10:35-10:50	Revealing features of mRNP organization using super resolution microscopy Selected Talk: Srivathsan Adivarahan, Universite de Montreal, Canada
10:50-11:20	Coffee Break
11:20-11:45	A subcellular compartment defined by TIS granules and the ER enables 3'UTR-mediated protein-protein interactions Christine Mayr, Memorial Sloan Kettering Cancer Center, USA
11:45-12:00	Identification and functional dissection of differentially localized mRNA isoforms in mESC-derived neurons Selected Talk: Marina Chekulaeva, BIMSB MDC, Germany
12:00-12:15	RNA-directed activation of cytoplasmic dynein-1 in reconstituted transport RNPs Selected Talk: Mark A. McClintock, MRC Laboratory of Molecular Biology, UK
12:15-12:40	*oskar* *mRNA transport in the Drosophila* germline** Anne Ephrussi, EMBL Heidelberg, Germany
12:40-12:55	Flash Talks: Talks selected from abstracts # 114, 118, 150, 238, 240, 242 (1 slide / 2 min each)
13:00 -16:00	Lunch & Poster session II (even numbers)
Session 5: Noncoding RNAs and decay 16:00 - 19:00 Chair: Torben Heick Jensen
16:00-16:25	Circular RNAs in innate immunity Ling-Ling Chen, Shanghai Institute of Biochemistry and Cell Biology, China
16:25-16:50	lncRNAs and circRNAs in cell differentiation and disease Irene Bozzoni, Sapienza University of Rome, Italy
16:50-17:15	Molecular and Physiological Functions of circRNAs Sebastian Kadener, Brandeis University, USA
17:15-17:45	Coffee Break
17:45-18:10	The structural basis for mRNA synthesis by influenza RNA-dependent RNA polymerase Stephen Cusack, EMBL Grenoble, France
18:10-18:25	Molecular mimicry in the complex life of the non-coding RNA Selected Talk: Odil Porrua, CNRS, France
18:25-18:40	Nuclear RNA decay is functionally linked to Polycomb-mediated transcriptional control in embryonic stem cells Selected Talk: William Garland, Aarhus University, Denmark
18:40-18:55	Structures of ykkC riboswitches bound to ppGpp and PRPP reveal a novel principle of ligand recognition Selected Talk: Alla Peselis, NYU School of Medicine, USA
19:00-19:15	Pre-Dinner Drinks
19:15-20:45	Dinner EMBL Canteen
20:45-23:00	Drinks and Poster Viewing

Day 4 - Saturday 6 October 2018
Time	Speaker
Session 6: RNA processing machinery 09:00 - 13:10 Chair: Eva Kowalinski
09:00-09:25	mRNA Deadenylation Is Coupled to Translation Rates by the Differential Activities of Ccr4-Not Nucleases Lori A. Passmore, MRC Laboratory of Molecular Biology, UK
09:25-09:50	Structural basis of AAUAAA polyadenylation on signal recognition by the human CPSF complex Martin Jinek, University of Zurich, Switzerland
09:50-10:05	Cryo-EM structure of a poly(A)-Pab1 ribonucleoprotein bound to the Pan2-Pan3 deadenylase Selected Talk: Ingmar Schäfer, Max Planck Institute for Biochemistry, Germany
10:05-10:20	MKRN1 is a Minder of Poly(A) in Ribosome-associated Quality Control Selected Talk: Andrea Hildebrandt, Institute of Molecular Biology, Germany
10:20-10:35	Structural basis of MLE-UNR-roX2 complex assembly during early steps of Drosophila dosage compensation Selected Talk: Janosch Hennig, EMBL Heidelberg, Germany
10:35-11:05	Coffee Break
11:05-11:30	tRNAs and neuron function Susan Ackerman, University of California, San Diego, USA
11:30-11:55	Assembly of yeast ribosome Keqiong Ye, Chinese Academy of Sciences, China
11:55-12:10	Unveiling (Class III) Gene Transcription Selected Talk: Alessandro Vannini, The Institute of Cancer Research, UK
12:10-12:25	The diverse roles of RNA helicases in driving structural transitions and compositional changes in RNA-protein complexes Selected Talk: Markus Bohnsack, University Medical Center Göttingen, Germany
12:25-12:40	Structure of a nucleolar precursor of the ribosome - the small subunit processome Selected Talk: Jonas Barandun, The Rockefeller University, USA
12:40-12:55	Structural insight of precursor tRNA processing by RNase P Selected Talk: Pengfei Lan, Shanghai Jiao Tong University School of Medicine, China
12:55-13:10	Flash Talks: Talks selected from abstracts # 262, 266, 278, 294, 314, 334 (1 slide / 2 min each)
13:10-16:30	Lunch & Poster session III (all numbers)
Session 7: Small RNAs and RNA tails 16:30 - 19:15 Chair: Ramesh Pillai
16:30-16:55	Understanding the roles and regulation of Dicer in antiviral defense Brenda L. Bass, University of Utah, USA
16:55-17:10	A zygotic small RNA feedback loop triggered by maternal small RNAs in Paramecium has implications for trans-generational epigenetic inheritance Selected Talk: Sarah Allen, IZB Universität Bern, Switzerland
17:10-17:35	Regulators of mRNA tails V. Narry Kim, Seoul National University, Republic of Korea
17:35-18:05	Coffee Break
18:05-18:20	RNA polymerase I regulation by RNA interference in cellular quiescence relies on a novel class of long non-coding RNAs Selected Talk: Benjamin Roche, Cold Spring Harbor Laboratory, USA
18:20-18:35	CRISPR knockout studies show that uridylation by TUTase 7 and the 3’ to 5’ exonuclease 3’hExo are required both for maintaining normal histone mRNA structure and for histone mRNA degradation Selected Talk: Christopher Holmquist, University of North Carolina at Chapel Hill, USA
18:35-18:50	High-throughput biochemical analyses reveal miRNA-specific binding preferences that markedly improve miRNA target predictions Selected Talk: Sean McGeary, HHMI, MIT, and Whitehead Institute, Cambridge, USA
18:50–19:15	Principles of RNA regulation by single sequencing in space and time Nikolaus Rajewsky, Max Delbrück Center for Molecular Medicine, Germany
19:15–19:45	Closing remarks and poster prize
19:45-21:45	Conference Dinner EMBL Canteen
21:45-00:00	Conference Party EMBL Foyer