Conference Programme

Location & dates EMBL Heidelberg, Germany 3 - 6 Oct 2018

Deadlines Registration closed Abstract submission closed

Day 1 - Wednesday 3 October 2018
Time	Speaker
15:00-17:45	Arrival and Registration
17:45-19:00	Welcome Dinner
Session 1: Keynote Session 19:00 - 20:45
19:00-19:15	Welcome Remarks
19:15-20:00	Keynote Talk 1: Reinhard Lührmann Novel mechanistic insights into the inner workings of the human spliceosome by combined biochemical and Cryo-EM studies Max Planck Institute for Biophysical Chemistry, Germany
20:00-20:45	Keynote Talk 2: Geraldine Seydoux Regulation of RNA granule dynamics by intrinsically-disordered proteins Johns Hopkins University School of Medicine, USA
20:45-23:00	Drinks and Poster "Sneak Preview"

Day 2 - Thursday 4 October 2018
Time	Speaker
Session 2: Splicing and RNPs 09:00-12:35 Chair: Kathi Zarnack
09:00-09:25	Complex Interactions between Transcription, Splicing and Chromatin Jean Beggs, University of Edinburgh, UK
09:25-09:50	Splicing-dependent regulation of transcription start sites Christopher B. Burge, Massachusetts Institute of Technology, USA
09:50-10:15	CryoEM snapshots of the spliceosome provide insights into the molecular mechanism of pre-mRNA splicing Kiyoshi Nagai, MRC Laboratory of Molecular Biology, UK
10:15-10:45	Coffee Break
10:45-11:10	Quantitative Activity Profile and Context-Dependence of all Human 5’ Splice Sites Adrian R. Krainer, Cold Spring Harbor Laboratory, USA
11:10-11:25	Global two-step pre-mRNA splicing kinetics in human cells Selected Talk: Leonhard Wachutka, TUM Germany
11:25-11:40	Self-regulatory network of the core spliceosome Selected Talk: Malgorzata Ewa Rogalska, CRG-Centre for Genomic Regulation, Universitat Pompeu Fabra, Spain
11:40-11:55	Systematic Identification and Quantitative Measurement of RNA-Protein Interactions by incPRINT Selected Talk: Alena Shkumatava, Institut Curie, France
11:55-12:20	Hidden treasures of the RNA world: RBPs from moonlighting to riboregulation Matthias Hentze, EMBL Heidelberg, Germany
12:20-12:35	Flash Talks: Talks selected from abstracts #57,133, 149, 233, 251 (1 slide / 2 min each)
12:35-16:00	Lunch & Poster session I (odd numbers)
Session 3: RNA modifications and features determining transcript fate 16:00 - 19:00 Chair: John Gross
16:00-16:25	RNA methylation in gene expression regulation Chuan He, The University of Chicago, USA
16:25-16:50	The regulatory potential of cytosine-5 RNA methylation in translation Michaela Frye, University of Cambridge, UK
16:50-17:15	Pseudouridine synthases modify human pre-mRNA co-transcriptionally and affect splicing Wendy Gilbert, Yale University, USA
17:15-17:30	Methylation of structured RNA by the m⁶A writer METTL16 is essential for mouse embryonic development Selected Talk: Mateusz Mendel
17:30-18:00	Coffee Break
18:00-18:15	Unraveling the link between translation termination and nonsense-mediated mRNA decay Selected Talk: Oliver Mühlemann
18:15-18:30	Codon and amino acid use is a major determinant of mRNA stability in humans Selected Talk: Olivia Rissland, University of Colorado, USA
18:30-18:45	Post-transcriptional regulation in T cell responses to infection and tumors is time- and context-dependent Selected Talk: Monika Wolkers, Sanquin Research, Landsteiner Laboratory, The Netherlands
18:45-19:00	Identification of a cyclin-dependent kinase coupling global protein synthesis rates with cell proliferation and growth Selected Talk: Katharina Haneke, Medical Faculty Mannheim, Germany
19:00-21:00	Pre-Dinner Drinks and Dinner EMBL Canteen
21:00-23:00	After Dinner Drinks ATC Rooftop Lounge

Day 3 - Friday 5 October 2018
Time	Speaker
Session 4: RNA localization and translation 09:00-13:00 Chair: Nicola Gray
09:00-09:45	Keynote Talk 3: Robert H. Singer: Watching single mRNAs form memories Albert Einstein College of Medicine, USA
09:45-10:10	Imaging the life and death of mRNAs in single cells Jeffrey A. Chao, Friedrich Miescher Institute for Biomedical Research, Switzerland
10:10-10:35	Uncovering rules and dynamics of nonsense-mediated mRNA decay using single molecule imaging Marvin Tanenbaum, Hubrecht Institute, The Netherlands
10:35-10:50	Revealing features of mRNP organization using super resolution microscopy Selected Talk: Srivathsan Adivarahan, Universite de Montreal, Canada
10:50-11:20	Coffee Break
11:20-11:45	A subcellular compartment defined by TIS granules and the ER enables 3'UTR-mediated protein-protein interactions Christine Mayr, Memorial Sloan Kettering Cancer Center, USA
11:45-12:00	Identification and functional dissection of differentially localized mRNA isoforms in mESC-derived neurons Selected Talk: Marina Chekulaeva, BIMSB MDC, Germany
12:00-12:15	RNA-directed activation of cytoplasmic dynein-1 in reconstituted transport RNPs Selected Talk: Mark A. McClintock, MRC Laboratory of Molecular Biology, UK
12:15-12:40	*oskar* *mRNA transport in the Drosophila* germline** Anne Ephrussi, EMBL Heidelberg, Germany
12:40-12:55	Flash Talks: Talks selected from abstracts # 114, 118, 150, 238, 240, 242 (1 slide / 2 min each)
13:00 -16:00	Lunch & Poster session II (even numbers)
Session 5: Noncoding RNAs and decay 16:00 - 19:00 Chair: Torben Heick Jensen
16:00-16:25	Circular RNAs in innate immunity Ling-Ling Chen, Shanghai Institute of Biochemistry and Cell Biology, China
16:25-16:50	lncRNAs and circRNAs in cell differentiation and disease Irene Bozzoni, Sapienza University of Rome, Italy
16:50-17:15	Molecular and Physiological Functions of circRNAs Sebastian Kadener, Brandeis University, USA
17:15-17:45	Coffee Break
17:45-18:10	The structural basis for mRNA synthesis by influenza RNA-dependent RNA polymerase Stephen Cusack, EMBL Grenoble, France
18:10-18:25	Molecular mimicry in the complex life of the non-coding RNA Selected Talk: Odil Porrua, CNRS, France
18:25-18:40	Nuclear RNA decay is functionally linked to Polycomb-mediated transcriptional control in embryonic stem cells Selected Talk: William Garland, Aarhus University, Denmark
18:40-18:55	Structures of ykkC riboswitches bound to ppGpp and PRPP reveal a novel principle of ligand recognition Selected Talk: Alla Peselis, NYU School of Medicine, USA
19:00-19:15	Pre-Dinner Drinks
19:15-20:45	Dinner EMBL Canteen
20:45-23:00	Drinks and Poster Viewing

Day 4 - Saturday 6 October 2018
Time	Speaker
Session 6: RNA processing machinery 09:00 - 13:10 Chair: Eva Kowalinski
09:00-09:25	mRNA Deadenylation Is Coupled to Translation Rates by the Differential Activities of Ccr4-Not Nucleases Lori A. Passmore, MRC Laboratory of Molecular Biology, UK
09:25-09:50	Structural basis of AAUAAA polyadenylation on signal recognition by the human CPSF complex Martin Jinek, University of Zurich, Switzerland
09:50-10:05	Cryo-EM structure of a poly(A)-Pab1 ribonucleoprotein bound to the Pan2-Pan3 deadenylase Selected Talk: Ingmar Schäfer, Max Planck Institute for Biochemistry, Germany
10:05-10:20	MKRN1 is a Minder of Poly(A) in Ribosome-associated Quality Control Selected Talk: Andrea Hildebrandt, Institute of Molecular Biology, Germany
10:20-10:35	Structural basis of MLE-UNR-roX2 complex assembly during early steps of Drosophila dosage compensation Selected Talk: Janosch Hennig, EMBL Heidelberg, Germany
10:35-11:05	Coffee Break
11:05-11:30	tRNAs and neuron function Susan Ackerman, University of California, San Diego, USA
11:30-11:55	Assembly of yeast ribosome Keqiong Ye, Chinese Academy of Sciences, China
11:55-12:10	Unveiling (Class III) Gene Transcription Selected Talk: Alessandro Vannini, The Institute of Cancer Research, UK
12:10-12:25	The diverse roles of RNA helicases in driving structural transitions and compositional changes in RNA-protein complexes Selected Talk: Markus Bohnsack, University Medical Center Göttingen, Germany
12:25-12:40	Structure of a nucleolar precursor of the ribosome - the small subunit processome Selected Talk: Jonas Barandun, The Rockefeller University, USA
12:40-12:55	Structural insight of precursor tRNA processing by RNase P Selected Talk: Pengfei Lan, Shanghai Jiao Tong University School of Medicine, China
12:55-13:10	Flash Talks: Talks selected from abstracts # 262, 266, 278, 294, 314, 334 (1 slide / 2 min each)
13:10-16:30	Lunch & Poster session III (all numbers)
Session 7: Small RNAs and RNA tails 16:30 - 19:15 Chair: Ramesh Pillai
16:30-16:55	Understanding the roles and regulation of Dicer in antiviral defense Brenda L. Bass, University of Utah, USA
16:55-17:10	A zygotic small RNA feedback loop triggered by maternal small RNAs in Paramecium has implications for trans-generational epigenetic inheritance Selected Talk: Sarah Allen, IZB Universität Bern, Switzerland
17:10-17:35	Regulators of mRNA tails V. Narry Kim, Seoul National University, Republic of Korea
17:35-18:05	Coffee Break
18:05-18:20	RNA polymerase I regulation by RNA interference in cellular quiescence relies on a novel class of long non-coding RNAs Selected Talk: Benjamin Roche, Cold Spring Harbor Laboratory, USA
18:20-18:35	CRISPR knockout studies show that uridylation by TUTase 7 and the 3’ to 5’ exonuclease 3’hExo are required both for maintaining normal histone mRNA structure and for histone mRNA degradation Selected Talk: Christopher Holmquist, University of North Carolina at Chapel Hill, USA
18:35-18:50	High-throughput biochemical analyses reveal miRNA-specific binding preferences that markedly improve miRNA target predictions Selected Talk: Sean McGeary, HHMI, MIT, and Whitehead Institute, Cambridge, USA
18:50–19:15	Principles of RNA regulation by single sequencing in space and time Nikolaus Rajewsky, Max Delbrück Center for Molecular Medicine, Germany
19:15–19:45	Closing remarks and poster prize
19:45-21:45	Conference Dinner EMBL Canteen
21:45-00:00	Conference Party EMBL Foyer