Location & dates EMBL Heidelberg, Germany 11 - 13 Sep 2019
Deadlines Registration closed Abstract submission closed
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Programme

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Day 1 - Wednesday 11 September 2019
TimeSpeaker
11:00-13:00 Registration and light refreshments
13:00-13:10 Opening remarks
13:10-17:10

Session 1
Chair: Nevan Krogan - University of California, San Francisco, USA

13:10-13:40

Genome Architecture Mapping: exploring state specific 3D genome topologies in brain cells
Ana Pombo - Max Delbrück Center for Molecular Medicine, Germany

13:40 -14:10

From genomic data to molecular insights: statistical models to learn about gene regulation
Nicholas Luscombe - University College London, UK

14:10-14:25

1 Selected talk: Dissecting the mechanisms of molecular and cellular variation in human adipogenesis
Alpern Daniel - EPFL, Switzerland

14:25-14:40

2 Selected talk: Rewiring of energy metabolism drives resistance to the proteasome inhibitor bortezomib
Celia Berkers - Utrecht University, The Netherlands

14:40-15:10

Biphasic input-output relationships—there might be no such thing as too much of a good thing 
Hana El-Samad - University of California, San Francisco, USA

15:10-15:40

Coffee break & meet the speakers

15:40-16:10

The power of ONE: Immunology in the age of single cell genomics
Ido Amit - Weizmann Institute of Science, Israel

16:10-16:25

3 Selected talk: Integration of single cell DNA and RNA sequencing data to unravel tumor subclones
Nicola Andrea Casiraghi - DKFZ, EMBL Heidelberg, Germany

16:25-16:40

4 Selected talk: Linking the tRNA epitranscriptome to cellular protein homeostasis using a novel comprehensive multi-omics approach 
Johannes Leufken - University of Bern, Switzerland

16:40-16:55

5 Selected talk: The pause-initiation limit restricts transcription activation in human cells
Saskia Gressel - Max Planck-Institute for Biophysical Chemistry, Germany

16:55-17:10

6 Selected talk: Multi-state synaptic phosphorylation barcodes in health and disease
Marcelo Coba - University of Southern California, USA

17:10-17:50

Flash Talks I - selected from abstracts # 69, 73, 75, 87, 99, 129, 131, 145, 163, 183
(1 slide / 2 min each) in ATC Auditorium

17:50-19:00

Poster Session I
Helix A (odd numbers)

19:00-21:00

Dinner in the EMBL Canteen

21:00-22:30 After dinner drinks in the ATC Rooftop Lounge
Day 2 - Thursday 12 September 2019
TimeSpeaker
09:00 - 12:45 Session 2 
Chair: Judit Villén - University of Washington, United States of America
09:00-09:30

Single cell proteome variability in human cells
Emma Lundberg - Science for Life Laboratory (KTH), Sweden

09:30-09:45

7 Selected talk: Integrated multiomics unravels metabolic diet-microbiota-host interactions
Maria Zimmermann-Kogadeeva - EMBL Heidelberg, Germany

09:45-10:00

8 Selected talk: Contextualizing signalling pathways with genomic and transcriptomic data to dissect drug efficacy and gene essentiality in cancer
Julio Saez-Rodriguez - Heidelberg University, Germany

10:00-10:30

Single Molecule Protein Sequencing
Edward Marcotte  - The University of Texas at Austin, USA

10:30-11:00

Coffee break & meet the speakers

11:00-11:30

Christopher Burge - Massachusetts Institute of Technology, USA

11:30-11:45 9 Selected talk: Prediction of drug-target interactions through drug and overexpression metabolome profiling
Duncan Holbrook-Smith - ETH Zurich, Switzerland
11:45-12:00

10 Selected talk: Towards improved biophysical models of protein folding to identify disease-causing mutations
Amelie Stein - University of Copenhagen, Denmark 

12:00-12:15

11 Selected talk: A Functional Map of HIV-Host Interactions in Primary Human T cells
Joseph Hiatt - University of California, San FranciscoUSA

12:15-12:45

Splicing kinetics and coordination revealed by direct nascent RNA sequencing through nanopores 
L. Stirling Churchman  - Harvard Medical School, USA

12:45-14:15

Lunch 

14:15-17:15

Session 3
Chair: Patrick Cramer - Max Planck Institute for Biophysical Chemistry, Germany

14:15-14:45

Towards predicting gene expression from DNA sequence
Jussi Taipale - University of Cambridge, UK

14:45-15:00

12 Selected talk: Deciphering the Signaling Network Landscape of Breast Cancer Supports Personalized Medicine
Marco Tognetti - University of Zurich, ETH Zurich, Switzerland

15:00-15:15

13 Selected talk: A reference map of the human protein interactome reveals tissue-specific biological mechanisms
Katja Luck - Dana-Farber Cancer Institute, USA

15:15-15:45

Encoding of cellular multi specificity by a model molecular switch
Tanja  Kortemme - University of California, San Francisco, USA

15:45-16:15

Coffee Break & meet the Speakers

16:15-16:45

From Proteomes to metabolomes - how a new generation of high-throughput analytics enables the prediction of the cellular metabolome
Markus Ralser - The Francis Crick Institute, UK and Charité University Medicine, Germany

16:45-17:15

Epigenetic variation across individuals reveal insights into disease mechanisms
Judith Zaugg - EMBL Heidelberg, Germany

17:15-17:50

Flash talks II - selected from abstracts # 38, 40, 42, 56, 64, 68, 102, 128, 133, 134, 146, 148, 154, 160,  170, 176, 184  (1 slide / 2 min each) in ATC Auditorium

17:50-19:00

Poster Session II 
Helix A (even numbers)

19:00-21:30

Banquet Dinner in the EMBL Canteen

21:30-00:00 Conference Party with DJ
Day 3 - Friday 13 September 2019
TimeSpeaker
09:00-12:30 Session 4
Chair: Judith Zaugg - EMBL Heidelberg, Germany
09:00-09:30

Reconstructing development and regeneration using single-cell genomics
Barbara Treutlein  - ETH Zürich, Switzerland

09:30-09:45

14 Selected talk: A multiomics driven approach for industrial-scale modeling of neurological disease using human induced pluripotent stem cells
Robert Altshuler - Novartis Institutes for Biomedical Research, USA 

09:45-10:00

15 Selected talk: Native molecule sequencing by nano-ID reveals synthesis and stability of RNA isoforms
Björn Schwalb - Max Planck Institute for Biophysical Chemistry, Germany

10:00-10:30

Cell signaling as a cognitive process? 
Philippe Bastiaens -Max Planck Institute of Molecular Physiology, Germany

10:30-11:00

Coffee Break & Meet the speakers

11:00-11:30

Systematic investigation of the regulation and function of alternative splicing networks 
Ben Blencowe - University of Toronto, Canada

11:30-12:00

Systems integration of metabolomics and in vivo metabolic flux analysis reveals complex regulatory networks in diabetic complications
Subramanium Pennathur - University of Michigan, USA

12:00-12:30

Proteomes in 3D
Paola Picotti - ETH Zurich, Switzerland

12:30-14:00

Lunch

14:00-16:30

Session 5
Chair: Uwe Sauer - ETH Zurich, Switzerland

14:00-14:30

Integrative modeling of biomolecular assembly structures
Andrej Sali - University of California, San Francisco, USA

14:30-15:00

Measuring the impact of amino acid substitutions on protein function proteome-wide
Judit Villén - University of Washington, USA

15:00-15:30

Multiplexed probing of chromatin effects on DNA double-strand break repair
Bas van Steensel - The Netherlands Cancer Institute, The Netherlands

15:30-16:00 Coffee Break & meet the speakers
16:00-16:15 16 Selected talk: Multi-omics define divergent gene expression regulation and drivers of esophageal squamous cell carcinoma
Wei Wu - UCSF, USA
16:15-16:30 17 Selected talk: The wild metabolism of domesticated tomato – multi-omic analysis of a Solanum lycopersicum-pennellii introgression population
Jedrzej Szymanski - Leibniz Institute of Plant Genetics and Crop Plant Research, Germany
16:30-17:00 Closing remarks
17:00 Departure