Location & dates EMBL Heidelberg, Germany 29 Sep - 2 Oct 2019
Deadlines Registration closed Abstract submission closed
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EMBL Courses and Conferences during the Coronavirus pandemic

With the onsite programme paused, many of our events are now being offered in virtual formats.


Registration is open as usual for many events, with back-up plans in place to move further courses and conferences online as necessary. Registration fees for any events affected by the COVID-19 disruption are fully refundable.


More information for participants of events at EMBL Heidelberg can be found here.

Programme

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Day 1 - Sunday 29 September 2019
TimeSpeaker
11:30 - 13:00

Arrival and Registration 
with light lunch

13:00 - 13:15 Opening Remarks
13:15 - 14:15 Keynote Lecture: Systematic genetic perturbation screens to map biological networks
Brenda Andrews - University of Toronto, Canada
14:15 - 17:15

Session 1
Chair: Patricia Wittkopp

14:15 - 14:45

Analysis of context-specific genetic effects using single-cell RNA-sequencing of differentiation iPS cells
Oliver Stegle - EMBL Heidelberg and German Cancer Research Center, Germany

14:45 - 15:00

Cross-species analysis of melanoma enhancer logic
Liesbeth Minnoye - KU Leuven - VIB, Belgium

15:00 - 15:30

Coffee Break and Meet the Speakers in ATC Foyer with:
Brenda Andrews - University of Toronto, Canada
Oliver Stegle - EMBL Heidelberg and German Cancer Research Center, Germany
Lars Steinmetz - EMBL Heidelberg, Germany
Maitreya Dunham - University of Washington, USA

15:30 - 16:00

New technologies to read, write, edit (and heal) genomes
Lars Steinmetz - EMBL Heidelberg, Germany

16:00 - 16:15

Comparative analysis of yeast species reveals transcriptional rewiring in cis and in trans
Gat Krieger - Weizmann Institute of Science, Israel

16:15 - 16:30

Cell-to-cell protein expression variability in the human immune system is a heritable and polygenic trait
Michael Morgan - Wellcome Sanger Institute, UK

16:30 - 16:45

Identifying signs of polygenic adaptation using polygenic scores
Olivier Bakker - University Medical Centre Groningen, The Netherlands

16:45 - 17:15

High throughput functional characterization of natural alleles in S. cerevisiae
Maitreya Dunham - University of Washington, USA

17:15 - 18:30

Speed Networking Session in ATC Foyer

18:30 - 20:00

Dinner in EMBL Canteen 

20:00 - 22:00

Welcome Reception with Live Music in the ATC Rooftop Lounge

Day 2 - Monday 30 September 2019
TimeSpeaker
09:00 - 12:00 Session 2
Chair: Marcelo Nobrega
09:00 - 09:30

Towards predicting gene expression from DNA sequence
Jussi Taipale - University of Cambridge, UK

09:30 - 09:45

Defining the architecture of complex traits to understand the emergent properties of genomes
Chris Jakobson - Stanford University School of Medicine, USA

09:45 - 10:15

The genomic aetiology of osteoarthritis
Eleftheria Zeggini - Helmholtz Zentrum München, Germany

10:15 - 10:45

Coffee Break and Meet the Speakers in ATC Foyer with:
Jussi Taipale - University of Cambridge, UK
Eleftheria Zeggini - Helmholtz Zentrum München, Germany
Marylyn Ritchie - University of Pennsylvania, USA

10:45 - 11:00

The genetic interaction landscape of human membrane transporters
Enrico Girardi - CeMM Research Center for Molecular Medicine, Austria

11:00 - 11:30

Exploring genomics and phenomics with machine learning toward an improved understanding of complex traits
Marylyn Ritchie - University of Pennsylvania, USA

11:30 - 11:45

Integration of transcriptome, proteome and phoshpoproteome data elucidates the genetic control of molecular networks
Andreas Beyer - University of Cologne, Germany

11:45 - 12:00

Context-sensitive analysis of genomic insulator function
Matt Maurano - New York University School of Medicine, USA

12:00 - 13:30

Lunch in ATC Foyer

13:30 - 17:00

Session 3
Chair: Leopold Parts

13:30 - 14:00

From epigenetic variation across individuals to insights into disease and ageing 
Judith Zaugg - EMBL Heidelberg, Germany

14:00 - 14:15

Single and combinatorial CRISPR gene perturbations with 3Cs gRNAs
Manuel Kaulich - Goethe University Frankfurt, Germany

14:15 - 14:30

Exploring the omnigenic model
Neel Prabh - Max Planck Institute for Evolutionary Biology, Germany

14:30 - 15:00

Single cells collectively reveal non-deterministic effects of genetic variants
Gaël Yvert - CNRS and École Normale Supérieure de Lyon, France

15:00 - 15:30

Coffee Break and Meet the Speakers in ATC Foyer with:
Judith Zaugg - EMBL Heidelberg, Germany
Gaël Yvert - CNRS and École Normale Supérieure de Lyon, France

15:30 - 16:30

Panel Discussion Session: Open science and opportunities in systems genetics
Moderator: Thomas Lemberger
Panel members:
Bart Deplancke - École Polytechnique Fédérale de Lausanne, Switzerland
Tuuli Lappalainen - New York Genome Center and Columbia University, USA
Michael Snyder - Stanford University, USA
Oliver Stegle - EMBL Heidelberg and German Cancer Research Center, Germany
Alexandra Zhernakova - University Medical Center Groningen, The Netherlands

16:30 - 17:00

Flash Talks Session 1
Pablo Baeza-Centurion (abstract #47) - Centre for Genomic Regulation, Spain
Marc Jan Bonder (abstract #53) - EMBL Heidelberg, Germany
Roeland Broekema (abstract #56) - University Medical Center Groningen, The Netherlands
Anneke Brümmer (abstract #57) - University of Lausanne, Switzerland
Bede Busby (abstract #59) - EMBL Heidelberg, Germany
Robert Linder (abstract #83) - University of California Irvine, USA
Alicia Zamudio (abstract #115) - Massachusetts Institute of Technology, USA

17:00 - 19:00

Poster Session 1 (odd numbers)
with beer, wine and snacks

19:00 - 20:30

Dinner in EMBL Canteen 

20:30 - 22:30

After Dinner Drinks in the ATC Rooftop Lounge

Day 3 - Tuesday 1 October 2019
TimeSpeaker
09:00 - 12:00 Session 4
Chair: Brenda Andrews
09:00 - 09:30

Using single-cell genomics to investigate transcriptional dynamics
Rickard Sandberg - Karolinska Institutet, Sweden

09:30 - 09:45

Dynamic control of transcription at different chromosome positions
Siqi Zhao - Washington University in St. Louis, USA

09:45 - 10:00

Single cell RNA-seq identifies the origins of heterogeneity in efficient cell transdifferentiation and reprogramming
Mirko Francesconi - LBMC and École Normale Supérieure de Lyon, France

10:00 - 10:15

Quantitative phenotyping of C. elegans drug responses
Andy Fraser - University of Toronto, Canada

10:15 - 11:00

Coffee Break and Meet the Speakers in ATC Foyer with:
Rickard Sandberg - Karolinska Institutet, Sweden
Patricia Wittkopp - University of Michigan, USA

11:00 - 11:15

An integrated deep mutational scanning approach to defining the PTEN genotype-phenotype map
Taylor Mighell - Oregon Health & Science University, USA

11:15 - 11:30

Curating an atlas of human gene function from CRISPR-Cas9 fitness screens
Joshua Pan - Broad Institute, USA

11:30 - 12:00

Impacts of mutations on regulatory networks
Patricia Wittkopp - University of Michigan, USA

12:00 - 13:30 Lunch in ATC Foyer
13:30 - 17:00 Session 5
Chair: Gaël Yvert
13:30 - 14:00

Solving protein structures and understanding genetic interactions using deep mutagenesis
Ben Lehner - Centre for Genomic Regulation, Spain

14:00 - 14:15

Sequencing the BXD family, a cohort for experimental systems genetics and precision medicine
David Ashbrook - The University of Tennessee Health Science Center, USA

14:15 - 14:30

Characterizing cell type specificity of eQTLs from estimated cell type abundances across GTEx tissues
Sarah Kim-Hellmuth - New York Genome Center, USA

14:30 - 15:00

Humans and their bugs: the role of host-microbiome interactions in health and diseases
Alexandra Zhernakova - University Medical Center Groningen, The Netherlands

15:00 - 15:30

Coffee Break and Meet the Speakers in ATC Foyer with:
Ben Lehner - Centre for Genomic Regulation, Spain
Alexandra Zhernakova - University Medical Center Groningen, The Netherlands
Bart Deplancke - École Polytechnique Fédérale de Lausanne, Switzerland

15:30 - 16:00

Dissecting the genetic and molecular basis of organismal phenotypes in the Drosophila Genetic Reference Panel
Bart Deplancke - École Polytechnique Fédérale de Lausanne, Switzerland

16:00 - 16:15

Disentangling genetic and environmental effects on the proteotypes of individuals
Natalie Romanov - EMBL Heidelberg, Germany

16:15 - 16:30

Fission yeast transcriptional heterogeneity surveyed by single cell RNA sequencing
Samuel Marguerat - MRC London Institute of Medical Sciences and Imperial College London, UK

16:30 - 17:00

Flash Talks Session 2
Jacob Bergstedt (abstract #50) - Institute Pasteur, France
Michal Chapal (abstract #62) - Weizmann Institute of Science, Israel
Pieter Clauw (abstract #64) - Gregor Mendel Institute, Austria
Julie Demars (abstract #68) - INRA, France
Nelly Frenkel (abstract #70) - Weizmann Institute of Science, Israel
Wei Shern Lee (abstract #82) - Murdoch Children's Research Institute, Australia
Josine Min (abstract #88) - University of Bristol, UK
Balázs Szappanos (abstract #106) - Biological Research Centre, Hungary

17:00 - 19:00 Poster Session 2 (even numbers)
with beer, wine and snacks
19:00 - 21:00 Conference Dinner in EMBL Canteen
21:00 - 00:00 Conference Party with DJ in the ATC Foyer
Day 4 - Wednesday 2 October 2019
TimeSpeaker
09:00 - 12:45 Session 6
Chair: Rickard Sandberg
09:00 - 09:30

The GTEx Consortium atlas of genetic regulatory effects across human tissues
Tuuli Lappalainen - New York Genome Center and Columbia University, USA

09:30 - 09:45

A high-resolution genetic map of the metazoan cell generated by image-based profiling of co-perturbations
Florian Heigwer - German Cancer Research Center and Heidelberg University, Germany

09:45 - 10:00

Adaptation is shaped by genetic architecture and genotype
Rob Jelier - KU Leuven, Belgium

10:00 - 10:30

Functionally dissecting the genetic landscape of complex human traits
Marcelo Nobrega - The University of Chicago, USA

10:30 - 11:00

Coffee Break and Meet the Speakers in ATC Foyer with:
Tuuli Lappalainen - New York Genome Center and Columbia University, USA
Marcelo Nobrega - The University of Chicago, USA
Leopold Parts - Wellcome Sanger Institute, UK
Michael Snyder - Stanford University, USA

11:00 - 11:30

Variation of gene essentiality in yeast and human
Leopold Parts - Wellcome Sanger Institute, UK

11:30 - 11:45

Simultaneous quantification of mRNA and protein in single cells reveals trans-acting genetic variation
Frank Albert - University of Minnesota, USA

11:45 - 12:45 Keynote Lecture: Big data and health
Michael Snyder - Stanford University, USA
12:45 - 13:00 Closing Remarks and Poster Prize
13:00 Packed Lunch and Departure