Location & dates EMBL Heidelberg, Germany 16 - 19 Oct 2019
Deadlines Registration closed Abstract submission closed
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Programme

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Day 1 - Wednesday 16 October 2019
TimeSpeaker
12:00 - 14:00 Arrival and Registration
14:00 - 14:15     

Welcome remarks

14:15 - 17:15    

Session 1 - Non-coding RNAs in prokaryotes
Chair: Jörg Vogel

14:15 - 14:45     

Astonishing redundancy in small RNA-mediated regulation
Gisela Storz - National Institutes of Health, USA

14:45 - 15:15     

Hierarchy in Hfq chaperon occupancy of small RNA targets plays a major role in their regulation
Hanah Margalit - The Hebrew University of Jerusalem, Israel

15:15 - 15:30

Novel sRNA-target interaction networks involved in adaptation to nutrient availability
Ira Iosub - Centre for Synthetic and Systems Biology, University of Edinburgh, UK

15:30 - 16:00     

Coffee break and Meet the Speakers

16:00 - 16:30

Small RNA targetomes and the RNA chaperone Hfq
Eric Massé - Université de Sherbrooke, Canada

16:30 - 16:45

RNA interactome of multi-drug resistant Staphylococcus aureus (MRSA) reveals RNAs that confer tolerance to last-line antibiotic treatment
Jai Tree - University of New South Wales, Australia

16:45 - 17:15

A new gradient-based approach to discovering RNA-binding proteins in bacteria
Jörg Vogel - University of Würzburg, Germany

17:15 - 17:45

Flash Talks: 

#81 Eric de Bony - Center for Medical Genetics, University of Ghent, Belgium
#117 Rucha Hebalkar - Hannover Medical School, Germany
#129 Shweta Jadhav - Cancer Science Institute of Singapore, National University of Singapore, Singapore
#141 Claudia Keller Valsecchi - MPI for Immunobiology and Epigenetics, Germany
#153 Benson Lim - Genome Institute of Singapore, Singapore
#157 Lucia Lorenzi - Ghent University, Belgium
#161 Barbara Mariotti - University of Verona, Italy
#169 Sophie Mockly - CNRS - University of Montpellier, France
#173 Auke Otten - Department of Dermatology, University of California, San Diego, USA
#201 Muhammad Shuaib - King Abdullah University of Science and Technology, Saudi Arabia
#219 Pablo Tristan-Ramos - GENYO, Centre for Genomics and Oncological Research, Granada; University of Granada, Spain

17:45 - 19:45

Poster Session 1 (odd numbers)

19:45 - 21:30

Dinner, EMBL Canteen

21:30 - 23:00

Welcome Reception, ATC Foyer

Day 2 - Thursday 17 October 2019
TimeSpeaker
09:00 - 12:30

Session 2 - miRNAs function and mechanisms
Chair: V. Narry Kim

09:00 - 09:30

Regulation mechanisms of microRNA biogenesis
V. Narry Kim - Institute for Basic Science, South Korea

09:30 - 10:00      MicroRNA Degradation by a Conserved Target RNA Regulates Animal Behavior 
Alena Shkumatava - Institut Curie, France
10:00 - 10:15 Let-7a-regulated translational readthrough of mammalian AGO1 generates a microRNA pathway inhibitor
Sandeep Eswarappa - Indian Institute of Science, India
10:15 - 10:45     

Coffee break and Meet the Speakers

10:45 - 11:15 RNA binding proteins in microRNA and other non-coding RNA biogenesis pathways
Gunter Meister - Universität Regensburg, Germany
11:15 - 11:45

MicroRNA Target Recognition
David Bartel - Massachusetts Institute of Technology, USA

11:45 - 12:00 Stem Cell miRNAs control L1 expression and retrotransposition
Constance Ciaudo - ETH Zürich, Switzerland
12:00 - 12:15 SAFB proteins alter the specificity of the Microprocessor and enable the processing of suboptimal hairpin substrates in clustered primary miRNA transcripts
Sebastian Herzog - Medical University Innsbruck, Austria
12:15 - 12:30 miRNA degradation in human physiology and pathology
Francesco Nicassio - Istituto Italiano di Tecnologia, Italy
12:30 - 14:00 Lunch and Meet the Speakers
13:00 - 14:00 Meet the Editors/ Panel discussion - ATC Auditorium
Chair: Irene Bozonni

Kerstin Brachhold - Wiley (Germany)
Sannie Culbertson - Cell Press, Elsevier (United States of America)
Andrea Leibfried - Life Science Alliance - Journal (Germany)
Esther Schnapp - EMBO Press, Wiley (Germany)

14:00 - 16:00 Session 3 - piRNAs, other types eukaryotic small RNAs (including tRF), transcriptional silencing
Chair: Constance Ciaudo
14:00 - 14:30 New biology and therapeutics from RNA structure and modification
Eric Miska - University of Cambridge, UK
14:30 - 15:00 Selective translation control by pseudouridine-modified tRNA fragments in stem and cancer cells
Cristian Bellodi - Lund University, Sweden
15.00 - 15.30 RNA organization within phase transitioned germ granules
Ruth Lehmann - New York University School of Medicine, USA
15:30 - 15:45 A heterochromatin-specific RNA export pathway facilitates piRNA production
Peter Refsing Andersen - MBG, Aarhus University, Denmark
15:45 - 16:00 Dicer-dependent transfer RNA-derived small RNAs promote intronic gene silencing
Sheng Kai Pong - University of Oxford, UK
16:00 - 16:15 Free afternoon; Buses to Walking Tour Old Town Heidelberg
Day 3 - Friday 18 October 2019
TimeSpeaker
09:00 - 12:00 Session 4 - Structure-function, evolution, modifications, ncRNA RBPs
Chair: Markus Hafner
09:00 - 09:30

Functional structures within lincRNAp21, an RNA important for mammalian stress response
Anna Marie Pyle - Yale University, USA

09:30 - 10:00 RNP Granules in Health and Disease
Roy Parker - University of Colorado Boulder, USA
10:00 - 10:15 Binding specificities of human RNA binding proteins towards structured and linear RNA sequences
Jilin Zhang - Karolinska Institutet, Sweden
10:15 - 10:45 Coffee break and Meet the Speakers
10:45 - 11:15 Molecular mechanisms underlying RNP granule formation, function and disease
Simon Alberti - Max Planck Institute of Molecular Cell Biology and Genetics, Germany
11:15 - 11:45

Genetic compensation and transcriptional adaptation
Didier Stainier - Max Planck Institute for Heart and Lung Research, Germany

11:45 - 12:00 Cross evolutionary profiling of RNA acetylation from nucleobase to near atomic resolution
Aldema Sas-Chen - Weizmann Institute of Science, Israel            
12:00 - 13:30 Lunch and Meet the Speakers
13:30 - 17:00 Session 5 - circRNAs
Chair: Irene Bozzoni
13:30 - 14:00

Biogenesis of circRNAs in neuromuscular differentiation and disease
Irene Bozzoni - Sapienza University of Rome, Italy

14:00 - 14:30

SINEUPs: a new antisense, long non-coding RNA-based platform to increase endogenous protein levels for therapy
Stefano Gustincich - Istituto Italiano di Tecnologia, Italy

14:30 - 14:45

Loss of RBM20-dependent TTN-derived circRNAs contribute to the RBM20-phenotype
Lucia Cocera Ortega - Amsterdam UMC, The Netherlands

14:45 - 15:00 The RNA-binding proteins MATR3 and SUGP2 act as novel regulators of AUG circRNA production
Eoghan T. O'Leary - Aarhus University, Denmark
15:00 - 15:30 Coffee break and Meet the Speakers
15:30 - 16:00

Elucidating the function of circRNAs in development and disease
Jørgen Kjems - Aarhus University, Denmark

16:00 - 16:30

Lnc-ing RNA Processing and Function
Ling-Ling Chen - Shanghai Institute of Biochemistry and Cell Biology, China

16:30 - 16:45 Alterations in linear and back-splicing as new players in Huntington’s Disease pathogenesis
Marta Biagioli - University of Trento, Italy
16:45 - 17:00 RNA polymerase II promoter escape regulates circular RNA formation     
Ana Miguel Fernandes - Max Delbrück Center for Molecular Medicine, Germany
17:00 - 17:30

Flash Talks: 

#56 Tamer Ali - Institute of Cardiovascular Regeneration, Germany
#58 Marcella Amorim - University of Tübingen, Germany
#100 Marc Friedländer - SciLifeLab, Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Sweden
#116 Daniel A. Lim - University of California, San Francisco, USA
#142 Hyeong Jin Kim - University of Alberta, Canada
#174 Sanna Vuoristo - University of Helsinki, Finland
#216 Roopa Thapar - University of Texas M.D. Anderson Cancer Center, USA
#222 Rachael Turner - Monash University, Australia
#75 Grazia Daniela Raffa - Sapienza University of Rome, Italy

 

17:30 - 19:30 Poster Session 2 (even numbers + #75)
19:30 - 21:30 Conference Dinner, EMBL Canteen
21:30 - 00:00 Conference party with live music, ATC Foyer
Day 4 - Saturday 19 October 2019
TimeSpeaker
09:00 - 12:15 Session 6 - ncRNA therapeutics and Long noncoding RNA 1
Chair: Daniel A. Lim
09:00 - 09:30 The potential for personalized microRNA therapeutics in cancer
Frank Slack - Harvard Medical School, USA
09:30 - 10:00

SINEUPs: a new antisense, long non-coding RNA-based platform to increase endogenous protein levels for therapy
Stefano Gustincich - Istituto Italiano di Tecnologia, Italy

10:00 - 10:15 Systematic evaluation of microRNA-132 as a therapeutic target in Alzheimer's disease
Hannah Walgrave - VIB-KULeuven, Belgium             
10:15 - 10:30 CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma
Daniel A. Lim - University of California, San Francisco, USA
10:30 - 11:00 Coffee break and Meet the Speakers
11:00 - 11:15

R-loop mediated trans-action of the APOLO long noncoding RNA
Federico Ariel - IAL CONICET Santa Fe, Argentina

11:15 - 11:30 Control of cell division by long noncoding RNAs
Lovorka Stojic - CRUK Cambridge Institute, UK
11:30 - 11:45 Identifying functional pseudogenes in the human transcriptome by long-read cDNA sequencing           
Seth Cheetham - University of Queensland, Australia
11:45 - 12:00 Pervasive functional micropeptides in humans encoded by non-canonical open reading frames
Jin Chen - University of California, San Francisco, USA
12:00 - 12:15 Characterization of a Y chromosome family of lncRNAs and their importance in the response of male non-small cell lung cancer cells to ionizing radiation
Ivan Martinez - West Virginia University, USA
12:15 - 13:30 Lunch and Meet the Speakers (EMBL Canteen)
13:30 - 17:00 Session 7 - Long noncoding RNA 2
Chair: John Rinn
13:30 - 14:00 Chromatin related functions of long noncoding RNAs in the regulation of cancer pathways
Maite Huarte - University of Navarra, Spain
14:00 - 14:30 Transposable elements: a source of regulatory innovation for the evolution of X chromosome inactivation strategies in mammals?
Claire Rougeulle - Université de Paris, France
14:30 - 14:45 RNA matchmaking remodels LncRNA structure and promotes PRC2 activity
Aaron Johnson - University of Colorado School of Medicine, USA
14:45 - 15:00 The NORAD lncRNA ‘riboregulates’ the assembly of two large RNP complexes that function in the nucleus
Mathias Munschauer - Helmholtz Institute for RNA-based Infection Research, Germany
15:00 - 15:30 Coffee break and Meet the Speakers
15:30 - 15:45 The expansion and reconfiguration of the GENCODE lncRNA catalogs based on long-read transcriptomics data      
Jonathan Mudge - EMBL-EBI, UK
15:45 - 16:00

The missing ‘linc’ between repetitive DNA and premature aging     
Lauren Ostrowski - University of Toronto, Canada

16:00 - 16:30

Differential Contribution of Steady-State RNA and Active Transcription in Chromatin Organization
John Rinn - University of Colorado Boulder, USA

16:30 - 17:00

Identifying conserved element combinations in long noncoding RNAs
Igor Ulitsky - Weizmann Institute of Science, Israel

17:00 - 17:15 Closing remarks
17.15 - 17.30 Departure (Buses to downtown and Frankfurt Airport)