Metabolism and epigenetics are intricately linked, playing a key role in development, cancer, immune signalling and ageing. This symposium brings together world-leading researchers exploring this nexus and will focus in particular on how metabolites and metabolic networks impact gene regulation, on recently discovered roles of metabolites in disease and how this opens novel therapeutic avenues. We will highlight enabling tools linking metabolites, their localisation within tissues and cells with the regulation of chromatin structure, gene activity and epigenetic inheritance.
Innovative molecular and computational tools that enable the detection of metabolites in time and space, as well as novel biology in powerful model organisms and clinical data have led to a renaissance of research on metabolism, especially in the context of epigenetics and gene regulation. The goal of our interdisciplinary symposium is to strengthen the connection between these fields, inspire novel ideas and enable collaborations at this frontier.
- Metabolic regulation of epigenetic marks
- Metabolic control of gene expression
- Metabolism in development and disease
- Systems analysis of metabolism
- Cancer metabolism
- Immune cell metabolism
- Novel tools for metabolism and epigenetics