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Neurovascular biology is a young, emerging field that aims to unravel the molecular communication between the nervous system and the vasculature. Both the nervous system and the vascular system share striking conceptual similarities in the assembly of cellular networks through guided growth and branching processes. Vascular and neural cells work together to form a number of functional tissue compartments. Endothelial cells, certain mural support cells (i.e., pericytes), astrocytes and neurons assemble the neurovascular unit (NVU), which establishes the blood-brain (BBB) and blood-retina barriers. In fact, many of the most debilitating neurodegenerative diseases and cognitive decline involve disruption of the neurovascular unit or compromised vascular function in the nervous system. It has become increasingly clear that the endothelium and mural support cells function go beyond nutrient supply and are instructive and structurally required to allow nervous system function.
The neurovascular link is an emerging concept that brings together two fields, vascular biology and neurobiology that were little interconnected in the past and therefore had very few opportunities to exchange knowledge. In this symposium, we aim to bring researchers at this interface to foster interdisciplinary exchange and new emerging concepts on how vascular and nervous system crosstalk to maintain organ homeostasis and function. This exchange is necessary to understand how cell-cell interactions at the interface of the different cellular entities in the brain are essential for brain health and homeostasis.
- Vessel-neuronal Structure
- Neurovascular Signaling
- Blood brain Barrier
- Neurovascular Coupling
- Neurovascular Pathology