EMBL Courses and Conferences during the Coronavirus pandemic
With the onsite programme paused, many of our events are now being offered in virtual formats.
Registration is open as usual for many events, with back-up plans in place to move further courses and conferences online as necessary. Registration fees for any events affected by the COVID-19 disruption are fully refundable.
More information for participants of events at EMBL Heidelberg can be found here.
Programme
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- The virtual symposium includes live-streamed invited speakers with Q&A sessions after each talk.
- Information on the live stream and access to the discussion platform and digital posters will be provided on Wednesday, 3 March 2021 (evening CET).
- Access to the recorded talks will be available until 29 March 2021 (23.59 CET).
The following times are used in the programme below:
- Central European Time (CET): eg. Berlin, Amsterdam Paris
- Eastern Daylight Time (EDT): eg. New York, Quebec
To find out the equivalent time zone in your location, enter Berlin, the CET programme time and your city into the Time Zone Converter.
| Time | Speaker |
|---|---|
| 15:00-15:15 (CET) 09:00-09:15 (EDT) |
Opening remarks by scientific organisers |
|
Virtual Session 1: Transcription-associated genomic instability |
|
| 15:15-15:40 (CET) 09:15-09:40 (EDT) |
Ribonucleotide Excision Repair - Genome Instability, Mutagenesis, and Inflammation AVAILABLE ON DEMAND AFTER LIVE STREAM |
|
15:40-15:45 (CET) |
Transition (to setup and switch to the next live talk) |
|
15:45-16:10 (CET) |
R-loops in Transcription Coupled DNA Double Strand Break repair AVAILABLE ON DEMAND AFTER LIVE STREAM |
| 16:10-16:15 (CET) 10:10-10:15 (EDT) |
Transition (to setup and switch to the next live talk) |
| 16:15-16:40 (CET) 10:15-10:40 (EDT) |
BRCA1, RAD52 and PALB2 promote novel small RNA-driven DNA repair Elodie Hatchi - Dana-Farber Cancer Institute, USA AVAILABLE ON DEMAND AFTER LIVE STREAM |
| 16:40-16:45 (CET) 10:40-10:45 (EDT) |
Transition (to setup and switch to the next live talk) |
|
16:45-17:00 (CET) 10:45-11:00 (EDT) |
DNA replication timing directly regulates the frequency of oncogenic translocations Rushad Pavri - IMP Vienna, Austria |
|
17:00-17:05 (CET) 11:00-11:05 (EDT |
Transition (to setup and switch to the next live talk) |
| 17:05-17:20 (CET) 11:05-11:20 (EDT) |
Rtt101/Cul4 may promote a ribonucleotide excision repair backup pathway in S phase Natalie Schindler - Johannes-Gutenberg University Mainz, Germany |
| 17:20-17:45 (CET) 11:20-11:45 (EDT) |
Break |
| 17:45-19:15 (CET) 11:45-13:15 (EDT) |
Digital poster session 1 |
| 19:15-19:40 (CET) 13:15-03:40 (EDT) |
Toxic R-loops: causes or consequences of DNA replication stress? Philippe Pasero - CNRS - Université de Montpellier, France AVAILABLE ON DEMAND AFTER LIVE STREAM |
|
19:40-19:45 (CET) |
Transition (to setup and switch to the next live talk) |
| 19:45-20:10 (CET) 13:45-14:10 (EDT) |
Chromatin dynamics, transcriptional homeostasis, and genome stability Craig Peterson - University of Massachusetts Medical School, USA AVAILABLE ON DEMAND AFTER LIVE STREAM |
| 20:10-20:15 (CET) 14:10-14:15 (EDT) |
Transition (to setup and switch to the next live talk) |
| 20:15-20:30 (CET) 14:15-14:30 (EDT) |
Chromatin-associated MRN complex protects highly transcribing genes from genomic instability Rosemary Kiernan - French National Centre for Scientific Research, France AVAILABLE ON DEMAND AFTER LIVE STREAM |
| 20:30-20:35 (CET) 14:30-14:35 (EDT) |
Transition (to setup and switch to the next live talk) |
| 20:35-20:50 (CET) 14:35-14:50 (EDT) |
Branchpoint translocation by fork remodellers as a general mechanism of R-loop removal Andrew Deans - St Vincent's Institute of Medical Research, Australia AVAILABLE ON DEMAND AFTER LIVE STREAM |
|
20:50-21:00 (CET) |
Short break |
| 21:00-22:00 (CET) 15:00-16:00 (EDT) |
Optional: Virtual Speed networking |
|
End of day 1 - Continued access to digital posters, networking and discussion platforms |
| Time | Speaker |
|---|---|
| Session 2 - Responses to transcription and replication stress Chair: Petra Beli |
|
| 15:00-15:25 (CET) 09:00-09:25 (EDT) |
Transcription during DNA damage and heat-shock Jesper Svejstrup - The Francis Crick Institute, UK AVAILABLE ON DEMAND AFTER LIVE STREAM |
| 15:25-15:30 (CET) 09:25-09:30 (EDT) |
Transition (to setup and switch to the next live talk) |
| 15:30-15:55 (CET) 09:30-09:55 (EDT) |
Resolution of conflicts of stalling RNA Polymerase with the replication fork by the MYCN oncoprotein |
| 15:55-16:00 (CET) 09:55-10:00 (EDT) |
Transition (to setup and switch to the next live talk) |
| 16:00-16:25 (CET) 10:00-10:25 (EDT) |
Coordinating chromosome replication with transcription |
| 16:25-16:30 (CET) 10:25-10:30 (EDT) |
Break (to setup and switch to the next live talk) |
| 16:30-16:45 (CET) 10:30-10:45 (EDT) |
A novel function of RNase H activities at arrested DNA replication forks in priming fork-resection Charlotte Audoynaud - Institut Curie / French National Centre for Scientific Research, France AVAILABLE ON DEMAND AFTER LIVE STREAM |
|
16:45-16:50 (CET) 10:45-10:50 (EDT) |
Transition (to setup and switch to the next live talk) |
|
16:50-17:05 (CET) 10:50-11:05 (EDT) |
Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability Jurgen Marteijn - Erasmus University Medical Center, The Netherlands AVAILABLE ON DEMAND AFTER LIVE STREAM |
| 17:05-17:30 (CET) 11:05-11:30 (EDT) |
Short break |
| 17:30-19:00 (CET) 11:30-13:00 (EDT) |
Digital poster session 2 |
|
19:00-19:25 (CET) |
SF3B1-targeted Splicing Inhibition Triggers Global Alterations in Transcriptional Dynamics and R-Loop Metabolism AVAILABLE ON DEMAND AFTER LIVE STREAM |
| 19:25-19:30 (CET) 13:25-13:30 (EDT) |
Transition (to setup and switch to the next live talk) |
| 19:30-19:55 (CET) 13:30-13:55 (EDT) |
The PBAF chromatin remodelling complex promotes G2/M checkpoint maintenance through regulation of the DREAM complex Jessica Downs - The Institute of Cancer Research, UK AVAILABLE ON DEMAND AFTER LIVE STREAM |
| 19:55-20:00 (CET) 13:55-14:00 (EDT) |
Transition (to setup and switch to the next live talk) |
| 20:00-20:15 (CET) 14:00-14:15 (EDT) |
A regulatory phosphosite on Mec1 controls RNAPII and RNAPIII occupancy during replication stress Jérôme Poli - Institute of Human Genetics, France AVAILABLE ON DEMAND AFTER LIVE STREAM |
| 20:15-20:20 (CET) 14:15-14:20 (EDT) |
Transition (to setup and switch to the next live talk) |
| 20:20-20:35 (CET) 14:20-14:35 (EDT) |
Genome-wide analysis of replication fork progression and stalling by TrAEL-seq Jon Houseley - Babraham Institute, UK AVAILABLE ON DEMAND AFTER LIVE STREAM |
| 20:35-21:00 (CET) 14:35-15:00 (EDT) |
Short break |
| 21:00-21:45 (CES) 15:00-15:45 (EDT) |
Optional: Virtual bar mixer |
|
End of day 2 - Continued access to digital posters, networking and discussion platforms |
| Time | Speaker |
|---|---|
| Session 3 - Interplay between transcription and DNA repair Chair: Georg Stoecklin |
|
| 15:00-15:25 (CET) 09:00-09:25 (EDT) |
R-loops act as promoters for antisense transcription Nicholas Proudfoot - University of Oxford, UK AVAILABLE ON DEMAND AFTER LIVE STREAM |
| 15:25-15:30 (CET) 09:00-09:30 (EDT) |
Transition (to setup and switch to the next live talk) |
| 15:30-15:55 (CET) 09:30-09:55 (EDT) |
R-loop proximity proteomics identifies a role of DDX41 in transcription-associated genomic instability Petra Beli - Institute of Molecular Biology, Germany AVAILABLE ON DEMAND AFTER LIVE STREAM |
| 15:55-16:00 (CET) 09:55-10:00 (EDT) |
Transition (to setup and switch to the next live talk) |
| 16:00-16:25 (CET) 10:00-10:25 (EDT) |
Uncovering noncoding RNA roles in the initiation of chromatin replication |
| 16:25-16:30 (CET) 10:25-10:30 (EDT) |
Transition (to setup and switch to the next live talk) |
| 16:30-16:45 (CET) 10:30-10:45 (EDT) |
Persistence of RNA transcription during DNA replication delays duplication of transcription start sites until G2/M Marco Saponaro - University of Birmingham, UK AVAILABLE ON DEMAND AFTER LIVE STREAM |
| 16:45-16:50 (CET) 10:45-10:50 (EDT) |
Transition (to setup and switch to the next live talk) |
| 16:50-17:05 (CET) 10:50-11:05 (EDT) |
Mediator link between transcription and DNA repair: new insights from the genome-wide location analysis of Rad26 and Rad1-Rad10 Julie Soutourina - CEA, France AVAILABLE ON DEMAND AFTER LIVE STREAM |
| 17:05-17:30 (CET) 11:05-11:30 (EDT) |
Short break |
| 17:30-19:00 (CET) 11:30-13:00 (EDT) |
Digital poster session 3 |
| 19:00-19:25 (CET) 13:00-13:25 (EDT) |
ATM and R-loop-dependent loss of protein homeostasis AVAILABLE ON DEMAND AFTER LIVE STREAM |
| 19:25-19:30 (CET) 13:25-13:30 (EDT) |
Transition (to setup and switch to the next live talk) |
| 19:30-19:55 (CET) 13:30-13:55 (EDT) |
Cytoplasmic hybrids derived from nuclear R-loops activate IRF3 signaling Madzia Crossley - Stanford Universtiy, USA AVAILABLE ON DEMAND AFTER LIVE STREAM |
| 19:55-20:00 (CET) 13:55-14:00 (EDT) |
Transition (to setup and switch to the next live talk) |
| 20:00-20:15 (CET) 14:00-14:15 (EDT) |
Rebuilding of initiation program over large transcribed regions rescues Common Fragile Site instability Stefano Gnan - Institute Curie, France |
| 20:15-20:20 (CET) 14:15-14:20 (EDT) |
Transition (to setup and switch to the next live talk) |
| 20:20-20:35 (CET) 14:20-14:35 (EDT) |
Dysregulation of R-loop homeostasis in the aging eye Hana Hall - Purdue University, USA AVAILABLE ON DEMAND AFTER LIVE STREAM |
|
End of day 3 - Continued access to digital posters, networking and discussion platforms |
| Time | Speaker | |
|---|---|---|
| Session 4 - Replication-transcription conflicts
Session chair: Andres Aguilera |
||
| 15:00-15:25 (CET) 09:00-09:25 (EDT) |
Genome-wide analysis of DNA replication conflicts Helle Ulrich - Institute of Molecular Biology & Johannes Gutenberg University of Mainz, Germany AVAILABLE ON DEMAND AFTER LIVE STREAM |
|
| 15:25-15:30 (CET) 09:25-09:30 (EDT) |
Transition (to setup and switch to the next live talk) |
|
| 15:30-15:55 (CET) 09:30-09:55 (EDT) |
Insights into genome stability and aging from the in vivo firing patterns of DNA replication origins in regenerating mouse livers Thanos Halazonetis - University of Geneva, Switzerland |
|
| 15:55-16:00 (CET) 09:55-10:00 (EDT) |
Transition (to setup and switch to the next live talk) |
|
| 16:00-16:25 (CET) 10:00-10:25 (EDT) |
The origins of R-Loop formation during replication-transcription conflicts |
|
| 16:25-16:30 (CET) 10:25-10:30 (EDT) |
Transition (to setup and switch to the next live talk) |
|
| 16:30-16:45 (CET) 10:30-10:45 (EDT) |
Replicon-seq: A new method to study sister replication fork movement and replication/transcription conflicts Clemence Claussin - Memorial Sloan Kettering Cancer Center, USA |
|
| 16:45-16:50 (CET) 10:45-10:50 (EDT) |
Transition (to setup and switch to the next live talk) | |
| 16:50-17:05 (CET) 10:50-11:05 (EDT) |
Role of MutSß and MutLß proteins in the restart of R-loop-stalled replication forks in human cells Esin Isik - University of Zurich, Switzerland |
|
| 17:05-17:30 (CET) 11:05-11:30 (EDT) |
Short break | |
| 17:30-17:55 (CET) 11:30-11:55 (EDT) |
New roles for ATP-dependent chromatin remodelers at transcription-replication conflicts Aleix Bayona-Feliu - Andalusian Molecular Biology and Regenerative Medicine Centre (CABIMER), Spain |
|
| 17:55-18:00 (CET) 11:55-12:00 (EDT) |
Transition (to setup and switch to the next live talk) |
|
| 18:00-18:25 (CET) 12:00-12:25 (EDT) |
TIAR is essential for G2/M checkpoint activation and retains CDK1 in nuclear G2/M transition granules upon replication stress Georg Stoecklin - Heidelberg University, Germany AVAILABLE ON DEMAND AFTER LIVE STREAM |
|
| 18:25-18:30 (CET) 12:25-12:30 (EDT) |
Transition (to setup and switch to the next live talk) |
|
| 18:30-18:55 (CET) 12:30-12:55 (EDT) |
Sequences that stall replication AVAILABLE ON DEMAND AFTER LIVE STREAM |
|
| 18:55-19:00 (CET) 12:55-13:00 (EDT) |
Transition (to setup and switch to the next live talk) |
|
| 19:00-19:25 (CET) 13:00-13:25 (EDT) |
Mechanisms of transcription-replication conflicts in oncogene-induced replication stress AVAILABLE ON DEMAND AFTER LIVE STREAM |
|
| 19:25-19:30 (CET) 13:25-13:30 (EDT) |
Break (to setup and switch to the next live talk) | |
| 19:30-19:45 (CET) 13:30-13:45 (EDT) |
Reconstitution of directional collisions of a eukaryotic replisome with an R-loop reveals multiple replication fork inhibition mechanisms Dirk Remus - Sloan Kettering Institute, USA AVAILABLE ON DEMAND AFTER LIVE STREAM |
|
| 19:45-19:50 (CET) 13:45-13:50 (EDT) |
Transition (to setup and switch to the next live talk) | |
| 19:50-20:05 (CET) 13:50-14:05 (EDT) |
The THO and TRAMP complexes prevent transcription-replication conflicts and protect against fragility of expanded CAG repeats Catherine Freudenreich - Tufts University, USA |
|
| 20:05-20:15 (CET) 14:05-14:15 (EDT) |
Closing remarks by scientific organizers & poster prize announcements | |
| Continued access to digital posters, networking and discussion platforms until 29 March 2021 | ||