Location & dates Virtual 9 - 12 Mar 2021
Deadlines Registration closed Abstract submission closed
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EMBL Courses and Conferences during the Coronavirus pandemic

With the onsite programme paused, many of our events are now being offered in virtual formats.


Registration is open as usual for many events, with back-up plans in place to move further courses and conferences online as necessary. Registration fees for any events affected by the COVID-19 disruption are fully refundable.


More information for participants of events at EMBL Heidelberg can be found here.

Programme

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  • The virtual symposium includes live-streamed invited speakers with Q&A sessions after each talk.
  • Information on the live stream and access to the discussion platform and digital posters will be provided on Wednesday, 3 March 2021 (evening CET).
  • Access to the recorded talks will be available until 29 March 2021 (23.59 CET).

The following times are used in the programme below:

  • Central European Time (CET): eg. Berlin, Amsterdam Paris
  • Eastern Daylight Time (EDT): eg. New York, Quebec

To find out the equivalent time zone in your location, enter Berlin, the CET programme time and your city into the Time Zone Converter.

Day 1 - Tuesday 9 March 2021
TimeSpeaker
15:00-15:15 (CET)
09:00-09:15 (EDT)
Opening remarks by scientific organisers

Virtual Session 1: Transcription-associated genomic instability
Session chair: Karlene Cimprich

15:15-15:40 (CET)
09:15-09:40 (EDT)

Ribonucleotide Excision Repair - Genome Instability, Mutagenesis, and Inflammation
Andrew Jackson - The University of Edinburgh, UK

AVAILABLE ON DEMAND AFTER LIVE STREAM

15:40-15:45 (CET)
09:40-09:45 (EDT)

Transition (to setup and switch to the next live talk)

15:45-16:10 (CET)
09:45-10:10 (EDT)

R-loops in Transcription Coupled DNA Double Strand Break repair
Gaëlle Legube - CNRS - University of Toulouse, France

AVAILABLE ON DEMAND AFTER LIVE STREAM

16:10-16:15 (CET)
10:10-10:15 (EDT)

Transition (to setup and switch to the next live talk)

16:15-16:40 (CET)
10:15-10:40 (EDT)

BRCA1, RAD52 and PALB2 promote novel small RNA-driven DNA repair

Elodie Hatchi - Dana-Farber Cancer Institute, USA

AVAILABLE ON DEMAND AFTER LIVE STREAM

16:40-16:45 (CET)
10:40-10:45 (EDT)

Transition (to setup and switch to the next live talk)

16:45-17:00 (CET)

10:45-11:00 (EDT)

DNA replication timing directly regulates the frequency of oncogenic translocations

Rushad Pavri - IMP Vienna, Austria

17:00-17:05 (CET)

11:00-11:05 (EDT

Transition (to setup and switch to the next live talk)
17:05-17:20 (CET)
11:05-11:20 (EDT)

Rtt101/Cul4 may promote a ribonucleotide excision repair backup pathway in S phase

Natalie Schindler - Johannes-Gutenberg University Mainz, Germany

17:20-17:45 (CET)
11:20-11:45 (EDT)

Break

17:45-19:15 (CET)
11:45-13:15 (EDT)

Digital poster session 1

19:15-19:40 (CET)
13:15-03:40 (EDT)

Toxic R-loops: causes or consequences of DNA replication stress?

Philippe Pasero - CNRS - Université de Montpellier, France

AVAILABLE ON DEMAND AFTER LIVE STREAM

19:40-19:45 (CET)
13:40-13:45 (EDT)

Transition (to setup and switch to the next live talk)

19:45-20:10 (CET)
13:45-14:10 (EDT)

Chromatin dynamics, transcriptional homeostasis, and genome stability

Craig Peterson - University of Massachusetts Medical School, USA

AVAILABLE ON DEMAND AFTER LIVE STREAM

20:10-20:15 (CET)
14:10-14:15 (EDT)

Transition (to setup and switch to the next live talk)

20:15-20:30 (CET)
14:15-14:30 (EDT)

Chromatin-associated MRN complex protects highly transcribing genes from genomic instability

Rosemary Kiernan - French National Centre for Scientific Research, France

AVAILABLE ON DEMAND AFTER LIVE STREAM

20:30-20:35 (CET)
14:30-14:35 (EDT)
Transition (to setup and switch to the next live talk)
20:35-20:50 (CET)
14:35-14:50 (EDT)

Branchpoint translocation by fork remodellers as a general mechanism of R-loop removal

Andrew Deans - St Vincent's Institute of Medical Research, Australia

AVAILABLE ON DEMAND AFTER LIVE STREAM

20:50-21:00 (CET)
14:50-15:00 (EDT)

Short break

21:00-22:00 (CET)
15:00-16:00 (EDT)

Optional: Virtual Speed networking

End of day 1 - Continued access to digital posters, networking and discussion platforms

Day 2 - Wednesday 10 March 2021
TimeSpeaker
Session 2 - Responses to transcription and replication stress
Chair: Petra Beli
15:00-15:25 (CET)
09:00-09:25 (EDT)

Transcription during DNA damage and heat-shock

Jesper Svejstrup - The Francis Crick Institute, UK

AVAILABLE ON DEMAND AFTER LIVE STREAM

15:25-15:30 (CET)
09:25-09:30 (EDT)

Transition (to setup and switch to the next live talk)

15:30-15:55 (CET)
09:30-09:55 (EDT)

Resolution of conflicts of stalling RNA Polymerase with the replication fork by the MYCN oncoprotein
Martin Eilers - University of Würzburg, Germany

15:55-16:00 (CET)
09:55-10:00 (EDT)

Transition (to setup and switch to the next live talk)

16:00-16:25 (CET)
10:00-10:25 (EDT)

Coordinating chromosome replication with transcription
Marco Foiani - University of Milan, Italy

16:25-16:30 (CET)
10:25-10:30 (EDT)

Break (to setup and switch to the next live talk)

16:30-16:45 (CET)
10:30-10:45 (EDT)

A novel function of RNase H activities at arrested DNA replication forks in priming fork-resection

Charlotte Audoynaud - Institut Curie / French National Centre for Scientific Research, France

AVAILABLE ON DEMAND AFTER LIVE STREAM

16:45-16:50 (CET)

10:45-10:50 (EDT)

Transition (to setup and switch to the next live talk)

16:50-17:05 (CET)

10:50-11:05 (EDT)

Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability

Jurgen Marteijn - Erasmus University Medical Center, The Netherlands

AVAILABLE ON DEMAND AFTER LIVE STREAM

17:05-17:30 (CET)
11:05-11:30 (EDT)

Short break

17:30-19:00 (CET)
11:30-13:00 (EDT)

Digital poster session 2 

19:00-19:25 (CET)
13:00-13:25 (EDT)

SF3B1-targeted Splicing Inhibition Triggers Global Alterations in Transcriptional Dynamics and R-Loop Metabolism
Frédéric Chédin - University of California, Davis, USA

AVAILABLE ON DEMAND AFTER LIVE STREAM

19:25-19:30 (CET)
13:25-13:30 (EDT)
Transition (to setup and switch to the next live talk)
19:30-19:55 (CET)
13:30-13:55 (EDT)

The PBAF chromatin remodelling complex promotes G2/M checkpoint maintenance through regulation of the DREAM complex

Jessica Downs - The Institute of Cancer Research, UK

AVAILABLE ON DEMAND AFTER LIVE STREAM

19:55-20:00 (CET)
13:55-14:00 (EDT)

Transition (to setup and switch to the next live talk)

20:00-20:15 (CET)
14:00-14:15 (EDT)

A regulatory phosphosite on Mec1 controls RNAPII and RNAPIII occupancy during replication stress

Jérôme Poli - Institute of Human Genetics, France

AVAILABLE ON DEMAND AFTER LIVE STREAM

20:15-20:20 (CET)
14:15-14:20 (EDT)

Transition (to setup and switch to the next live talk)

20:20-20:35 (CET)
14:20-14:35 (EDT)

Genome-wide analysis of replication fork progression and stalling by TrAEL-seq

Jon Houseley - Babraham Institute, UK

AVAILABLE ON DEMAND AFTER LIVE STREAM

20:35-21:00 (CET)
14:35-15:00 (EDT)

Short break

21:00-21:45 (CES)
15:00-15:45 (EDT)

Optional: Virtual bar mixer

End of day 2 - Continued access to digital posters, networking and discussion platforms

Day 3 - Thursday 11 March 2021
TimeSpeaker
Session 3 - Interplay between transcription and DNA repair
Chair: Georg Stoecklin
15:00-15:25 (CET)
09:00-09:25 (EDT)

R-loops act as promoters for antisense transcription

Nicholas Proudfoot - University of Oxford, UK 

AVAILABLE ON DEMAND AFTER LIVE STREAM

15:25-15:30 (CET)
09:00-09:30 (EDT)

Transition (to setup and switch to the next live talk)

15:30-15:55 (CET)
09:30-09:55 (EDT)

R-loop proximity proteomics identifies a role of DDX41 in transcription-associated genomic instability

Petra Beli - Institute of Molecular Biology, Germany

AVAILABLE ON DEMAND AFTER LIVE STREAM

15:55-16:00 (CET)
09:55-10:00 (EDT)

Transition (to setup and switch to the next live talk)

16:00-16:25 (CET)
10:00-10:25 (EDT)

Uncovering noncoding RNA roles in the initiation of chromatin replication
Maite Huarte - University of Navarre, Spain

16:25-16:30 (CET)
10:25-10:30 (EDT)

Transition (to setup and switch to the next live talk)

16:30-16:45 (CET)
10:30-10:45 (EDT)

Persistence of RNA transcription during DNA replication delays duplication of transcription start sites until G2/M

Marco Saponaro - University of Birmingham, UK

AVAILABLE ON DEMAND AFTER LIVE STREAM

16:45-16:50 (CET)
10:45-10:50 (EDT)
Transition (to setup and switch to the next live talk)
16:50-17:05 (CET)
10:50-11:05 (EDT)

Mediator link between transcription and DNA repair: new insights from the genome-wide location analysis of Rad26 and Rad1-Rad10

Julie Soutourina - CEA, France

AVAILABLE ON DEMAND AFTER LIVE STREAM

17:05-17:30 (CET)
11:05-11:30 (EDT)
Short break
17:30-19:00 (CET)
11:30-13:00 (EDT)

Digital poster session 3

19:00-19:25 (CET)
13:00-13:25 (EDT)

ATM and R-loop-dependent loss of protein homeostasis
Tanya Paull - University of Texas at Austin, USA

AVAILABLE ON DEMAND AFTER LIVE STREAM

19:25-19:30 (CET)
13:25-13:30 (EDT)

Transition (to setup and switch to the next live talk)

19:30-19:55 (CET)
13:30-13:55 (EDT)

Cytoplasmic hybrids derived from nuclear R-loops activate IRF3 signaling

Madzia Crossley - Stanford Universtiy, USA

AVAILABLE ON DEMAND AFTER LIVE STREAM

19:55-20:00 (CET)
13:55-14:00 (EDT)

Transition (to setup and switch to the next live talk)

20:00-20:15 (CET)
14:00-14:15 (EDT)

Rebuilding of initiation program over large transcribed regions rescues Common Fragile Site instability

Stefano Gnan - Institute Curie, France

20:15-20:20 (CET)
14:15-14:20 (EDT)

Transition (to setup and switch to the next live talk)

20:20-20:35 (CET)
14:20-14:35 (EDT)

Dysregulation of R-loop homeostasis in the aging eye

Hana Hall - Purdue University, USA

AVAILABLE ON DEMAND AFTER LIVE STREAM

End of day 3 - Continued access to digital posters, networking and discussion platforms

Day 4 - Day Friday 12 March 2021
TimeSpeaker
Session 4 - Replication-transcription conflicts

Session chair: Andres Aguilera

15:00-15:25 (CET)
09:00-09:25 (EDT)

Genome-wide analysis of DNA replication conflicts

Helle Ulrich - Institute of Molecular Biology & Johannes Gutenberg University of Mainz, Germany

AVAILABLE ON DEMAND AFTER LIVE STREAM

15:25-15:30 (CET)
09:25-09:30 (EDT)

Transition (to setup and switch to the next live talk)

15:30-15:55 (CET)
09:30-09:55 (EDT)

Insights into genome stability and aging from the in vivo firing patterns of DNA replication origins in regenerating mouse livers

Thanos Halazonetis - University of Geneva, Switzerland

15:55-16:00 (CET)
09:55-10:00 (EDT)

Transition (to setup and switch to the next live talk)

16:00-16:25 (CET)
10:00-10:25 (EDT)

The origins of R-Loop formation during replication-transcription conflicts
Houra Merrikh - Vanderbilt University, USA

16:25-16:30 (CET)
10:25-10:30 (EDT)

Transition (to setup and switch to the next live talk)

16:30-16:45 (CET)
10:30-10:45 (EDT)

Replicon-seq: A new method to study sister replication fork movement and replication/transcription conflicts

Clemence Claussin - Memorial Sloan Kettering Cancer Center, USA

16:45-16:50 (CET)
10:45-10:50 (EDT)
Transition (to setup and switch to the next live talk)
16:50-17:05 (CET)
10:50-11:05 (EDT)

Role of MutSß and MutLß proteins in the restart of R-loop-stalled replication forks in human cells

Esin Isik - University of Zurich, Switzerland

17:05-17:30 (CET)
11:05-11:30 (EDT)
Short break
17:30-17:55 (CET)
11:30-11:55 (EDT)

New roles for ATP-dependent chromatin remodelers at transcription-replication conflicts

Aleix Bayona-Feliu - Andalusian Molecular Biology and Regenerative Medicine Centre (CABIMER), Spain

17:55-18:00 (CET)
11:55-12:00 (EDT)

Transition (to setup and switch to the next live talk)

18:00-18:25 (CET)
12:00-12:25 (EDT)

TIAR is essential for G2/M checkpoint activation and retains CDK1 in nuclear G2/M transition granules upon replication stress

Georg Stoecklin - Heidelberg University, Germany

AVAILABLE ON DEMAND AFTER LIVE STREAM

18:25-18:30 (CET)
12:25-12:30 (EDT)

Transition (to setup and switch to the next live talk)

18:30-18:55 (CET)
12:30-12:55 (EDT)

Sequences that stall replication
Julian Sale - MRC Laboratory of Molecular Biology, UK

AVAILABLE ON DEMAND AFTER LIVE STREAM

18:55-19:00 (CET)
12:55-13:00 (EDT)

Transition (to setup and switch to the next live talk)

19:00-19:25 (CET)
13:00-13:25 (EDT)

Mechanisms of transcription-replication conflicts in oncogene-induced replication stress
Eva Petermann - University of Birmingham, UK

AVAILABLE ON DEMAND AFTER LIVE STREAM

19:25-19:30 (CET)
13:25-13:30 (EDT)
Break (to setup and switch to the next live talk)
19:30-19:45 (CET)
13:30-13:45 (EDT)

Reconstitution of directional collisions of a eukaryotic replisome with an R-loop reveals multiple replication fork inhibition mechanisms

Dirk Remus - Sloan Kettering Institute, USA

AVAILABLE ON DEMAND AFTER LIVE STREAM

19:45-19:50 (CET)
13:45-13:50 (EDT)
Transition (to setup and switch to the next live talk)
19:50-20:05 (CET)
13:50-14:05 (EDT)

The THO and TRAMP complexes prevent transcription-replication conflicts and protect against fragility of expanded CAG repeats

Catherine Freudenreich - Tufts University, USA

20:05-20:15 (CET)
14:05-14:15 (EDT)
Closing remarks by scientific organizers & poster prize announcements
Continued access to digital posters, networking and discussion platforms until 29 March 2021